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Optical Manipulation of Inorganic and Organic Objects in Soft Microfluidic Devices

Published online by Cambridge University Press:  17 March 2011

Cengiz S. Ozkan ,
Erhan Ata ,
Mihrimah Ozkan  and
Sadik C. Esener
Cengiz S. Ozkan
Affiliation:
Applied Micro Circuits Corporation, San Diego, CA 92121
Erhan Ata
Affiliation:
Department of Electrical and Computer Engineering, University of California at San Diego, La Jolla, CA 92093
Mihrimah Ozkan
Affiliation:
Department of Electrical and Computer Engineering, University of California at San Diego, La Jolla, CA 92093
Sadik C. Esener
Affiliation:
Department of Electrical and Computer Engineering, University of California at San Diego, La Jolla, CA 92093
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Abstract

We describe a technique for trapping and manipulation of inorganic and organic objects in microfluidic channels, based on photonic momentum transfer using an optical tweezers arrangement. Microfluidic devices have been fabricated by polydimethylsiloxane (PDMS) elastomer molding of patterns lithographically defined on a thick negative photoresist. Polystyrene microspheres dispersed in water were transferred into the fluidic channels using a syringe pump. Microspheres and live biological cells are trapped and redirected by optical manipulation within the fluidic channels. Optical trapping and patterning will have applications in creation of active cellular arrays for cell biology research, tissue engineering, cell sorting and drug discovery.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 657: Symposia EE – Materials Science of Microelectromechanical Systems (MEMS) Devices III , 2000 , EE5.2
Copyright
Copyright © Materials Research Society 2001

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References

REFERENCES

1. Bousse, L., Cohen, C., Nikiforov, T., Chow, A., Kopf-Sill, A.R., Dubrow, R. and Parce, J.W., “Electrokinetically Controlled Microfluidic Analysis Systems”, Annu. Rev. Biomol, Struct., 29, 155–181 (2000).Google Scholar
2. Ozkan, M., Ozkan, C.S., Wang, M.M., Kibar, O., Bhatia, S., and Esener, S., “Heterogeneous Integration of Biological Species and Inorganic Objects by Electrokinetic Movement”, IEEE Engineering in Medicine and Biology, in print.Google Scholar
3. Smith, S.P., Bhalotra, S.R., Brody, A.L., Brown, B.L., Boyda, E.K. and Prentiss, M., “Inexpensive Optical Tweezers for Undergraduate Laboratories”, Am. J. Phys., 67, 1 (1999).Google Scholar
4. Ashkin, A., “Forces of a Single-Beam Gradient Laser Trap on a Dielectric Sphere in the Ray Optics Regime”, Biophys. J., 61, 569–582 (1992).Google Scholar
5. Berns, M.W., Aist, J.R., Wright, W.H. and Liang, H., “Optical Trapping in Animal and Fungal Cells Using a Tunable, Near Infrared Titanium Sapphire Laser”, Experimental Cell Research, 198, 375–378 (1992).Google Scholar
6. Wang, M., Ozkan, M., Wen, P., Sanchez, M., Ata, E., Ozkan, C. S., Kibar, O. and Esener, S., “Integration of Optoelectronic Arrays for Cell Transport and Sorting”, will be presented at the BIOS 2001 Meeting.Google Scholar