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Optimization of Mesoporous Silicon Microcavities for Proteomic Sensing

Published online by Cambridge University Press:  01 February 2011

L. A. DeLouise  and
B. L. Miller
L. A. DeLouise
Affiliation:
Department of Dermatology and Center for Future Health, University of Rochester Medical Center, 697 Elmwood Ave, Rochester NY 14642, USA
B. L. Miller
Affiliation:
University of Rochester, Departments of Biochemistry and BioPhysics, University of Rochester Medical Center, 697 Elmwood Ave, Rochester NY 14642, USA
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Abstract

To expand the utility of p+ mesoporous silicon devices in proteomic biosensor applications, we have conducted in-depth studies to quantify the impact of employing a strong base post etch process to modify the microstructure of microcavity sensors tuned to operate in the visible spectrum. Changes in the optical response and quality of the cavity are quantified as a function of potassium hydroxide (KOH) exposure and initial porosity. Our results show that an aqueous ethanol solution containing millimolar concentrations of KOH is an effective means not only to increase the porosity and pore size, thereby enhancing pore infiltration of large (40–50kDa) proteins, but also to fine tune the optical properties of a passive optical devices.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 782: Symposium A – Micro- and Nanosystems , 2003 , A5.3
Copyright
Copyright © Materials Research Society 2004

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References

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