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Patterned Polymer Nanofibers Based Biosensors
Published online by Cambridge University Press: 22 June 2011
Abstract
“Label-free” biomolecule sensors for detection of inflammatory cardiovascular biomarker associated with vulnerable coronary vascular plaque were designed and fabricated using micro and nano-textured polystyrene structures that functioned as sensing elements coupled with electronic measurement equipment. We demonstrated that scaling down the surface texturing from the micro to the nanoscale enhances the amplitude of the measured signal strength. We believe that the nanoscale fiber morphology provides size matched spaces for trapping and immobilizing the protein biomolecules resulting in enhanced detection and signal strength. We selected polystyrene as the model system and demonstrated the detection of human serum C-reactive protein (hs-CRP). We employed these findings in designing a platform “lab-on-a-chip” protein sensor. Comparative studies were performed on two different polystyrene textured surfaces: a polystyrene microsphere mat, and an electrospun polystyrene nanofiber matrix.
- Type
- Research Article
- Information
- MRS Online Proceedings Library (OPL) , Volume 1358: Symposium MM – Organic Bioelectronics and Photonics for Sensing and Regulation , 2011 , mrss11-1358-mm03-07
- Copyright
- Copyright © Materials Research Society 2011
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