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Poly(Phosphoesters) as Bioabsorbable Osteosynthetic Materials

Published online by Cambridge University Press:  15 February 2011

S. Kadiyala ,
M. Richards ,
B. Dahiyat ,
J. D. Michelson  and
K. W. Leong
S. Kadiyala
Affiliation:
Department of Biomedical EngineeringThe Johns Hopkins University Baltimore, MD 21218
M. Richards
Affiliation:
The Biomechanics, Trauma and Sports Medicine Laboratory, University of Michigan, Ann Arbor, Michigan 48105
B. Dahiyat
Affiliation:
Department of Biomedical EngineeringThe Johns Hopkins University Baltimore, MD 21218
J. D. Michelson
Affiliation:
Department of Orthopaedic Surgery
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Abstract

Polymeric prosthetic devices enjoy the advantage of tailor-made properties. In particular bioabsorbable polymers possess distinct advantages. In orthopedic applications, most osteosynthesis has been achieved using metallic devices to stabilize fixation of bony fragments. The different elastic moduli of the metallic implants versus that of bone often causes cortical bone to atrophy. The theoretical advantage of gradual load transfer from the fixation device to the bone and the elimination of surgical removal after the healing of a fracture make an absorbable osteosynthetic material extremely useful. A resorbable porous coating material would also have the potential of improving fixation by promoting bony ingrowth and reducing cartilage destruction. The structural support function of a polymeric device can also be integrated with the drug-carrier function to take advantage of the recently discovered growth factors such as bone morphogenic proteins in enhancing bone union.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 252: Symposium T – Tissue-Inducing Biomaterials , 1991 , 311
Copyright
Copyright © Materials Research Society 1992

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References

REFERENCES

1. Richards, M, Dahiyat, B I, Arm, D M, Brown, P R, and Leong, K W: Evaluation of polyphosphates and polyphosphonates as degradable biomaterials, J. Biomed. Mat. Res., 25, 1151, 1991 Google Scholar
2. Richards, M, Dahiyat, B I, Arm, D M, Lin, S, and Leong, K W: Interfacial polycondensation and characterization of polyphosphates and polyphosphonates, J. Polym. Sci. A: Polym. Chem., 29, 1157, 1991 Google Scholar
3. Dahiyat, B I, Richards, M, and Leong, K W: Controlled release from poly(phosphoester) matrices, J. Controlled Rel., submittedGoogle Scholar
4. Harrigan, T P, Karch, J, and Harris, W H: The influence of support conditions in the loading and failure mechanisms in the push out test: a finite element study, J. Orthopedic Res., 8, 678, 1990 Google Scholar