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Synthesis and Self-assembly of DMPC-conjugated Gold Nanoparticles

Published online by Cambridge University Press:  01 February 2011

Subhasish Chatterjee ,
Markrete Krikorian ,
Harry D. Gafney  and
Bonnie Gersten
Subhasish Chatterjee
Affiliation:
schatterjee@gc.cuny.edu, The Graduate Center of CUNY, the City College of New York, and Queens College, Chemistry, Marshak Science Building, J-1209, Convent Avenue & 138th Street,, New York, NY, 10031, United States, 917-224-9320
Markrete Krikorian
Affiliation:
mk2874@columbia.edu, Townsend Harris High School, Flushing, NY, 11367, United States
Harry D. Gafney
Affiliation:
harry.gafney@qc.cuny.edu, Queens College, Chemistry, Flushing, NY, 11367, United States
Bonnie Gersten
Affiliation:
bonniegersten@gmail.com, Queens College, Chemistry, Flushing, NY, 11367, United States
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Abstract

Bio-conjugated nanomaterials play a promising role in the development of novelsupramolecular structures, molecular machines, and biosensing devices. In this study, lipid-capped gold nanoparticles were synthesized and allowed to form a self-assembled monolayer structure. The nanoparticles were prepared by a phase transfer method, which involved the reduction of potassium tetrachloroaurate(III) by sodium citrate in an aqueous solution and the simultaneous transfer of the reduced species to an organic medium containing DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine). The gold nanoparticles were characterized using Uv-vis spectroscopy and dynamic light scattering (DLS) particle-size analysis. In addition, the resulting nanoparticles were examined using transmission electron microscopy (TEM). The Langmuir-Blodgett (LB) technique was used to assemble the DMPC-capped nanoparticles onto a water subphase at room temperature. The measurement of the compression isotherm confirmed the assemblage of lipid capped gold nanoparticles. This method of synthesis of ordered structures utilizing molecular interactions of lipids will be useful in developing novel metamaterials and nanocircuits.

Keywords

Auself-assemblynanostructure
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1061: Symposium MM – Biomolecular and Biologically Inspired Interfaces and Assemblies , 2007 , 1061-MM09-08
Copyright
Copyright © Materials Research Society 2008

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