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Tailored Viscosity Reduction in Aqueous Hydroxypropylcellulose Solutions

Published online by Cambridge University Press:  21 February 2011

Victoria A. Prevysh ,
Richard J. Spontak  and
Saad A. Khan
Victoria A. Prevysh
Affiliation:
Department of Meterials Science & Engineering, N. Carolina State University, Raleigh NC 27695
Richard J. Spontak
Affiliation:
Department of Meterials Science & Engineering, N. Carolina State University, Raleigh NC 27695
Saad A. Khan
Affiliation:
Department of Chemical Engineering, N. Carolina State University, Raleigh NC 27695
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Abstract

Polysaccharides, including cellulosic derivatives such as hydroxypropylcellulose (HPC), are used extensively in the pharmaceutical industry due to their biocompatibility and self-organization properties. While drug delivery vehicles employing, for instance, aqueous polysaccharide gels are desirable, production of such gels can be hindered by tremendously high solution viscosity. In this work, we describe a novel means by which to reduce the viscosity and enhance the solubility of aqueous HPC. Here, the efficacy of several additives which promote HPC viscosity reduction through molecular salting-in is examined by dynamic rheology and light/electron microscopy.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 394: Symposium Z – Polymers in Medicine and Pharmacy , 1995 , 137
Copyright
Copyright © Materials Research Society 1995

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References

1. Gray, D.G. and Harkness, B.R., in liquid Crystalline and Mesomophic Polymers, edited by Shibaev, V.P. and Lam, L. (Springer-Verlag, New York, 1994) Chap. 9.Google Scholar
2. Ambrosino, S. and Sixou, P., in Polymer Association Structures, edited by El-Nokaly, M.A. (ACS Symp. Ser. 384, Washington, D.C., 1989) Chap. 10.Google Scholar
3. Conio, G., Bianchi, E., Ciferri, A., Tealdi, A., and Aden, M.A., Macromolecules 16, 1264 (1983).Google Scholar
4. Dunn, R. L., in Polymeric Drugs and Drug Delivery Systems, edited by Dunn, R. L. and Ottenbrite, R.M. (ACS Symp. Ser. 469, Washington, D.C., 1991) Chap. 2.Google Scholar
5. Wang, B.-C. and Theil, M.H., presented at the 207th ACS National Meeting, San Diego, CA, 1994 (unpublished).Google Scholar
6. Spontak, R.J., El-Nokaly, M.A., Bartolo, R.G., and Bums, J.L., in Polymer Solutions. Blends. and Interfaces edited by Noda, L. and Rubingh, D.N. (Elsevier, Amsterdam, 1992) pp. 273–298.Google Scholar
7. Hoffmeister, F., Arch. Exptl. Pathol. Pharmokol. 24, 247 (1888).Google Scholar
8. Luck, W.A., in Water in Polymers, edited by Rowland, S.P. (ACS Symp. Ser. 127, Washington, D.C., 1980) Chap. 3.Google Scholar
9. Prevysh, V.A., Wang, B.-C., Khan, S.A., and Spontak, R.J., presented at the 209th ACS National Meeting, Anaheim, CA, 1995 (unpublished).Google Scholar
10. Prud'home, R.K., Constien, V., and Knoll, S., in Polymers in Aqueous Media edited by Glass, J.E. (ACS Symp. Ser. 223, Washington, D.C., 1989) Chap. 6.Google Scholar
11. Khan, S.A., Baker, G.L., and Colson, S., Chem. Mater. 6, 2359 (1994).Google Scholar
12. Livolant, F. and Bouligand, Y., Mol. Cryst. Liq. Cryst. 166, 91 (1989).Google Scholar