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Universal Correlation and Mechanism for the Antibacterial Activity of Silver Nanoparticles

Published online by Cambridge University Press:  31 January 2011

Georgios A. Sotiriou ,
Adrian Camenzind ,
Frank Krumeich ,
Andreas Meyer ,
Sven Panke  and
Sotiris E. Pratsinis
Georgios A. Sotiriou
Affiliation:
geosotiriou@ptl.mavt.ethz.ch, Particle Technology Laboratory, Department of Mechanical and Process Engineering, Zurich, Switzerland
Adrian Camenzind
Affiliation:
camenzind@ptl.mavt.ethz.ch, Particle Technology Laboratory, Department of Mechanical and Process Engineering, Zurich, Switzerland
Frank Krumeich
Affiliation:
krumeich@inorg.chem.ethz.ch, Particle Technology Laboratory, Department of Chemistry and Applied Biosciences, Zurich, Switzerland
Andreas Meyer
Affiliation:
andreas.meyer@bsse.ethz.ch, Bioprocess Laboratory, Department of Biosystems Science and Engineering, Basel, Switzerland
Sven Panke
Affiliation:
sven.panke@bsse.ethz.ch, Bioprocess Laboratory, Department of Biosystems Science and Engineering, Basel, Switzerland
Sotiris E. Pratsinis
Affiliation:
pratsinis@ptl.mavt.ethz.ch, Particle Technology Laboratory, Department of Mechanical and Process Engineering, Zurich, Switzerland
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Abstract

Silver clusters (4-150 nm) anchored on nanostructured silica particles (300-400 m2/g) with closely controlled Ag content and size were made in one-step by scalable flame spray pyrolysis of Ag-nitrate and hexamethyldisiloxane containing solutions. Composite Ag/SiO2 nanoparticles were characterized by S/TEM, EDX spectroscopy, X-ray diffraction, N2 adsorption. The activity of such nanoparticles against the Gram negative bacterium Escherichia coli was investigated by monitoring the recombinantly synthesized green fluorescent protein. It is shown that higher Ag content particles exhibit a stronger antibacterial effect.

Keywords

Agcompositebiomaterial
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1209: Symposia P/YY – Business and Safety Issues in the Commercialization of Nanotechnology , 2009 , 1209-YY01-07
Copyright
Copyright © Materials Research Society 2010

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References

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