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Use of Anodized Titanium in Drug Delivery Applications

Published online by Cambridge University Press:  01 February 2011

Chang Yao ,
Ganesan Balasundaram  and
Thomas Webster
Chang Yao
Affiliation:
chang_yao@brown.edu, Brown University, Division of Engineering, 182 Hope St., Providence, RI, 02912, United States
Ganesan Balasundaram
Affiliation:
Ganesan_Balasundaram@brown.edu, Brown University, Providence, RI, 02912, United States
Thomas Webster
Affiliation:
thomas_webster@brown.edu, Brown University, Providence, RI, 02912, United States
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Abstract

One approach to improve the performance of current titanium implants is to create nanostructures via surface modification. Anodization is known to produce nanotubular structures on titanium surfaces when using fluorine containing solutions. Previous studies revealed enhanced osteoblast (bone-forming cell) adhesion and calcium deposition on anodized titanium possessing nanotubular structures compared to unanodized titanium. Moreover, it was found that protein adsorption (specifically, vitronectin and fibronectin) prior to cell adhesion increased on anodized compared to unanodized samples. These results all indicate that anodized titanium would be a good candidate for novel orthopedic implants. The nanotubes created by anodization have an inner diameter from 40 to 100 nm and a depth of a few hundred nanometers. In the present study, the drug delivery capability of such nanotubular structures was further characterized. Three different model drugs were tested: immunoglobulin G for foreign body response, bone morphogenetic protein active fragment for new bone growth, and penicillin/streptomycin for antimicrobial. First, these proteins were allowed to adsorb onto substrates for 24 h under room temperature. Then, the substrates with absorbed proteins were rinsed and transferred to new buffer solution kept at 37 °C. Buffer solution was collected and changed everyday. Finally, protein release from each substrate was measured using a commercial BCA assay kit. Results showed decreased immunoglobulin G adsorption, increased bone morphogenetic protein and penicillin/streptomycin adsorption on anodized titanium compared to unanodized ones. The release behavior of each protein on anodized and unanodized titanium is also studied.

Keywords

Tiadsorptionbone
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 951: Symposium E – Nanofunctional Materials, Nanostructures and Novel Devices for Biological and Chemical Detection , 2006 , 0951-E12-28
Copyright
Copyright © Materials Research Society 2007

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References

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