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The metabolism of 4-aminobutyrate (GABA) in fungi

Published online by Cambridge University Press:  01 April 1997

SANTOSH KUMAR  and
NARAYAN S. PUNEKAR
SANTOSH KUMAR
Affiliation:
Biotechnology Centre, Indian Institute of Technology – Bombay, Powai, Bombay 400 076, India
NARAYAN S. PUNEKAR
Affiliation:
Biotechnology Centre, Indian Institute of Technology – Bombay, Powai, Bombay 400 076, India
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Abstract

Information on the genetics and metabolism of 4-aminobutyrate (GABA) in yeasts and fungi is reviewed. In spite of ubiquitous occurrence, there is limited information on its function and biological role. Most fungi utilize GABA both as a carbon and a nitrogen source. Fungal endogenous GABA largely originates from the decarboxylation of L-glutamate and is associated with sporulation/spore metabolism. Whatever its source, GABA is catabolized to succinate via succinicsemialdehyde. Taken together these steps define a potential bypass outside the classical tricarboxylic acid cycle. Evidence for the existence of such a functional bypass in fungi is reviewed. The role of GABA and its metabolism in various facets of fungal biology is gradually emerging.

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Type
Research Article
Information
Mycological Research , Volume 101 , Issue 4 , April 1997 , pp. 403 - 409
Copyright
The British Mycological Society 1997

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