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Mating and virulence of Candida albicans

Published online by Cambridge University Press:  03 December 2003

DAVID R. SOLL ,
SHAWN R. LOCKHART  and
RUI ZHAO
DAVID R. SOLL
Affiliation:
Department of Biological Sciences, The University of Iowa. Iowa City, Iowa 52242
SHAWN R. LOCKHART
Affiliation:
Department of Biological Sciences, The University of Iowa. Iowa City, Iowa 52242
RUI ZHAO
Affiliation:
Department of Biological Sciences, The University of Iowa. Iowa City, Iowa 52242
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Abstract

Recently, it was demonstrated that Candida albicans contains mating type genes. Since that discovery, it has been demonstrated that the majority of strains contain both a and "[agr ]" a genes, that a minority are homozygous for a or "[agr ]" and can undergo fusion, and that the cytological stages of fusion and zygote development are similar to the stages of mating in Saccharomyces cerevisiae. However, it has recently been demonstrated that in order to mate, homozygous a and homozygous "[agr ]" cells must undergo phenotypic switching from the white to opaque phase, adding a developmental step to mating that might be related to pathogenesis.

Keywords

Candidamating locusmeiosisphenotypic switchingvirulence
Type
Original Article
Information
Mycologist , Volume 17 , Issue 2 , May 2003 , pp. 64 - 69
Copyright
© 2003 Cambridge University Press

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