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Neurostatin: cellular sources and cellular targets of the inhibitor

Published online by Cambridge University Press:  31 March 2006

MAYTE VALLEJO-CREMADES  and
MANUEL NIETO-SAMPEDRO
MAYTE VALLEJO-CREMADES
Affiliation:
Neural Plasticity Group, Instituto Cajal, Madrid, Spain
MANUEL NIETO-SAMPEDRO
Affiliation:
Neural Plasticity Group, Instituto Cajal, Madrid, Spain
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Abstract

Neurostatin, a modified ganglioside in mammalian brain, is highly immunogenic. Fusion of spleen cells of Balb/C mice immunized with bovine neurostatin with SP2O myeloma cells, led to hybridoma producers of anti-neurostatin antibodies. Two, monoclonal, IgG secreters were selected that recognized the inhibitor in blots and tissue of cow, rat and pig. The lack of species specificity indicated that the molecular structure of the inhibitory epitope is similar in these mammals. That epitope was also present in other gangliosides of the b series, defining a new regulatory system of glial-cell proliferation and apoptosis. The antibodies further revealed the neuronal origin of neurostatin.

Keywords

astrocytosisapoptosisanti-mitoticglia differentiationastrogliosisreactive glia
Type
Articles
Information
Neuron Glia Biology , Volume 2 , Issue 2 , May 2006 , pp. 115 - 123
Copyright
Cambridge University Press 2005

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