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NG2-positive glia in the human central nervous system

Published online by Cambridge University Press:  29 September 2009

Susan M. Staugaitis  and
Bruce D. Trapp
Susan M. Staugaitis
Affiliation:
Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA
Bruce D. Trapp*
Affiliation:
Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
*
Correspondence should be addressed to: Bruce D. Trapp, Department of Neurosciences, Cleveland Clinic, 9500 Euclid Avenue NC30, Cleveland OH 44195, USA phone: 216-444-7177 fax: 216-444-7927 email: trappb@ccf.org
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Abstract

Cells that express the NG2 chondroitin sulfate proteoglycan and platelet-derived growth factor receptor alpha (NG2 glia) are widespread in the adult human cerebral cortex and white matter and represent 10–15% of non-neuronal cells. The morphology and distribution of NG2 glia are similar to, but distinct from, both microglia and astrocytes. They are present as early as 17 weeks gestation and persist throughout life. NG2 glia can be detected in a variety of human central nervous system (CNS) diseases, of which multiple sclerosis is the best studied. NG2 glia show morphological changes in the presence of pathology and can show expression of the Ki-67 proliferation antigen. The antigenic profile and morphology of NG2 glia in human tissues are consistent with an oligodendrocyte progenitor function that has been well established in rodent models. Most antibodies to NG2 do not stain formalin-fixed paraffin-embedded tissues. Advances in our understanding of NG2 glia in human tissues will require the development of more robust markers for their detection in routinely processed human specimens.

Keywords

Chondroitin sulfate proteoglycanplatelet-derived growth factor alphaoligodendrocyte progenitor cellsyntanocytepolydendrocyte
Type
Research Article
Information
Neuron Glia Biology , Volume 5 , Special Issue 3-4: NG2-Glia, Part II: NG2 Cells as Neural Precursors , November 2009 , pp. 35 - 44
Copyright
Copyright © Cambridge University Press 2009

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