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Effects of phyto-oestrogens on tissues

Published online by Cambridge University Press:  24 October 2008

John J. B Anderson ,
Mary Anthony ,
Mark Messina  and
Sanford C Garne
John J. B Anderson*
Affiliation:
Department of Nutrition, Schools of Public Health and Medicine, University of North Carolina, Chapel Hill, NC 27599-7400, USA.
Mary Anthony
Affiliation:
Department of Nutrition, Schools of Public Health and Medicine, University of North Carolina, Chapel Hill, NC 27599-7400, USA.
Mark Messina
Affiliation:
Department of Nutrition, Schools of Public Health and Medicine, University of North Carolina, Chapel Hill, NC 27599-7400, USA.
Sanford C Garne
Affiliation:
Department of Nutrition, Schools of Public Health and Medicine, University of North Carolina, Chapel Hill, NC 27599-7400, USA.
*
*Corresponding author: Dr J. Anderson, fax 001 919 966 7216, email jjb_anderson@unc.edu
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Abstract

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Recent investigations on the effects of phyto-oestrogens on various tissues have revealed that these diverse molecules may improve human health, particularly by protecting against certain chronic diseases. After a brief examination of the food sources, structures, and general cellular actions of the major phyto-oestrogens, current research findings on cardiovascular disease, skeletal tissues, and reproductive cancers are reviewed. Phyto-oestrogen concentrations in blood may be maintained at high levels in those consuming soyabean (Glycine max)-based food daily at several meals and exert their effects on target cells through either genomic effects via the classical oestrogen receptors or non-genomic effects mediated by membrane-bound oestrogen receptors or other cellular proteins. The expression of oestrogen receptor (OR) subtypes alpha (a) and beta (β) varies across tissues, and cells that preferentially express OR-β, which may include bone cells, are more likely to respond to phyto-oestrogens. Conversely, reproductive tissues contain relatively more OR-a and may, thus, be differently affected by phyto-oestrogens. Soyabean phyto-oestrogens appear to prevent the progression of atherosclerosis through multiple interactions, including lowering of plasma lipids and lipoproteins, increased vasodilatation and, possibly, decreased activation of blood platelets and vascular smooth muscle cells. However, a favourable impact on cardiovascular disease morbidity and mortality by a soyabean-enriched western-type diet remains to be shown, and unresolved questions remain regarding dose and form of the phyto-oestrogens in relation to risks and benefits. The isoflavones of soyabean have been shown consistently to have bone-retentive effects in animal studies by several investigators using rodent models, although intakes must be above a relatively high threshold level for a lengthy period of time, and little or no extra benefit is observed with intakes above this threshold level. The reports of modest or no effects on prevention of bone loss in human and non-human primate studies respectively, may be due to the limited doses tested so far. The relationship between soyabean-food intake and cancer risk has been more extensively investigated than for any other disease, but with less certainty about the benefits of long-term consumption of phyto-oestrogen-containing foods on prevention of cancer. The observations that breast and prostate cancer rates are lower in Asian countries, where soyabean foods are consumed at high levels, and the high isoflavone content of soyabeans have led to examination of the potential protective effects of phyto-oestrogens. Establishing diet-cancer relationships has proved difficult, in part because of the conflicting data from various studies of effects of soyabean-diets on cancer. Epidemiological evidence, though not impressive, does suggest that soyabean intake reduces breast cancer risk. The isoflavone genistein has a potent effect on breast cancer cells in vitro, and early exposure of animals to genistein has been effective in reducing later development of mammary cancer. Thus, continuous consumption of soyabean foods in early life and adulthood may help explain the low breast cancer mortality rates in Asian countries. Although the evidence for a protective effect against prostate cancer may be slightly more supportive, more research is needed before any firm conclusions can be made about the phyto-oestrogen-cancer linkages.

Keywords

Phyto-oestrogensSoyabeanCancerBoneBlood lipids
Type
Research Article
Information
Nutrition Research Reviews , Volume 12 , Issue 1 , June 1999 , pp. 75 - 116
Copyright
Copyright © CABI Publishing 1999

References

Adlercreutz, H, Markkanen, H & Watanabe, S (1993) Plasma concentrations of phyto-oestrogens in Japanese men. Lancet 342, 1209–1210.CrossRefGoogle ScholarPubMed
Adlercreutz, H & Mazur, W (1997) Phyto-estrogens and western diseases. Annals of Medicine 29, 95–120.CrossRefGoogle ScholarPubMed
Adlercreutz, H, van der Wilt, J, Kinzel, J, Attalla, H, Wähalä, K, Mäkelä, T, Hase, T & Fotsis, T (1995) Lignan and isoflavonoid conjugates in human urine. Journal of Steroid Biochemistry and Molecular Biology 52, 97–103.CrossRefGoogle ScholarPubMed
Akiyama, T, Ishida, J, Nakagawa, S, Ogawara, H, Watanabe, S, Itoh, N, Shibuya, M & Fukami, Y (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. Journal of Biological Chemistry 262, 5592–5595.CrossRefGoogle ScholarPubMed
Anderson, JJ, Ambrose, WW & Garner, SC (1995 a) Orally dosed genistein from soy and prevention of cancerous bone in two ovariectomized rat models. Journal of Nutrition 125, 799S.Google Scholar
Anderson, JJB, Ambrose, WW & Garner, SC (1998) Biphasic effects of genistein on bone tissue in the ovariectomized, lactating rat model. Proceedings of the Society for Experimental Biology and Medicine 217, 345–350.CrossRefGoogle Scholar
Anderson, JJB & Garner, SC (1997) The effects of phyto-estrogens on bone. Nutrition Research 20, 220–224.Google Scholar
Anderson, JJB & Miller, CP (1998) Lower lifetime estrogen exposure among vegetarians as a possible risk factor for osteoporosis: a hypothesis. Vegetarian Nutrition 2, 4–12.Google Scholar
Anderson, JJB, Thomsen, K & Christiansen, C (1987) High protein meals, insular hormones, and urinary calcium excretion in human subjects. In Osteoporosis 1987, pp. 240–245 [Christiansen, C, Johnson, JS and B, Riis, editors]. Copenhagen, Denmark: Osteopress ApSGoogle Scholar
Anderson, JW, Johnstone, BM & Cook-Newell, ME (1995 b) Meta-analysis of the effects of soy protein intake on serum lipids. New England Journal of Medicine 333, 276–282.CrossRefGoogle ScholarPubMed
Anderson, RL & Wolf, WJ (1995) Compositional changes in trypsin inhibitors, phytic acid, saponins and isoflavones related to soybean processing. Journal of Nutrition 125, 581S–588S.Google ScholarPubMed
Anonymous (1977) Report of the American Institute of Nutrition ad hoc Committee on Standards for Nutritional Studies. Journal of Nutrition 107, 1340–1348.CrossRefGoogle Scholar
Anthony, MS & Clarkson, TB (1998) Comparison of soy phyto-estrogens and conjugated equine oestrogens on atherosclerosis progression in postmenopausal monkeys. Circulation 97, 829.Google Scholar
Anthony, MS, Clarkson, TB, Bullock, BC & Wagner, JD (1997) Soy protein versus soy phyto-estrogens in the prevention of diet-induced coronary artery atherosclerosis of male cynomolgus monkeys. Arteriosclerosis, Thrombosis and Vascular Biology 17, 2524–2531.CrossRefGoogle ScholarPubMed
Anthony, MS, Clarkson, TB, Hughes, CL, Morgan, TM & Burke, GL (1996) Soybean isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal rhesus monkeys. Journal of Nutrition 126, 43–50.CrossRefGoogle ScholarPubMed
Anthony, MS, Clarkson, TB & Williams, JK (1998) Effect of soy isoflavones on atherosclerosis potential mechanisms. American Journal of Clinical Nutrition 68, 1390S–1393S.CrossRefGoogle ScholarPubMed
Arjmandi, BH, Alekel, L, Hollis, BW, Amin, D, Stacewicz-Sapuyntzakis, M, Guo, P & Kukreja, SC (1996) Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis. Journal of Nutrition 126, 161–167.CrossRefGoogle Scholar
Arnold, SF, Collins, BM, Robinson, MK, Guillette, LJ & McLachlan, JA (1996) Differential interaction of natural and synthetic oestrogens with extracellular binding proteins in a yeast oestrogen screen. Steroids 61, 642–646.CrossRefGoogle Scholar
Arts, J, Kuiper, GGJM, Janssen, JMMF, Gustafsson, JÅ, Löwik, CWGM, Pol, HAP & Van Leeuwen, JPTM (1997) Differential expression of estrogen receptors a and b mRNA during differentiation of human osteoblast SV-HFO cells. Endocrinology 138, 5067–5070.CrossRefGoogle Scholar
Asahi, M, Yanagi, S, Ohta, S, Inazu, T, Sakai, K, Takeuchi, F, Taniguchi, T & Yamamura, H (1992) Thrombin-induced human platelet aggregation is inhibited by protein-tyrosine kinase inhibitors, ST638 and genistein. FEBS Letters 309, 10–14.CrossRefGoogle ScholarPubMed
Baggott, JE, Ha, T, Vaughn, WH, Juliana, MM, Hardin, JM & Grubbs, CJ (1990) Effect of miso (Japanese soybean paste) and NaCl on DMBA-induced rat mammary tumors. Nutrition and Cancer 14, 103–109.CrossRefGoogle ScholarPubMed
Balmir, F, Staack, R, Jeffrey, E, Berber-Jimenez, MD, Wang, L & Potter, SM (1996) An extract of soya flour influences serum cholesterol and thyroid hormones in rats and hamsters. Journal of Nutrition 126, 3046–3053.CrossRefGoogle Scholar
Barnes, S, Grubbs, C, Setchell, KDR & Carlson, J (1990) Soybeans inhibit mammary tumors in models of breast cancer. In Mutagens and Carcinogens in the Diet, pp. 239–253 [Pariza, MW, Aeschbacher, H-U, Felton, JS and Sato, S, editors]. New York, NY: Wiley LissGoogle Scholar
Baum, JA, Teng, H, Erdman, JW, Weigel, RM, Klein, BP, Persky, VW, Freels, S, Surya, P, Bakhit, RM, Ramos, E, Shay, NF & Potter, SM (1998) Long-term intake of soy protein improves blood lipid profiles and increases mononuclear cell LDL receptor mRNA in hypercholesterolemic postmenopausal women. American Journal of Clinical Nutrition 68, 545–551.CrossRefGoogle ScholarPubMed
Bennetts, HW, Underwood, EJ & Shier, FL (1946) A specific breeding problem of sheep on subterranean clover pastures in western Australia. Australian Veterinary Journal 22, 2–12.CrossRefGoogle ScholarPubMed
Benten, WPM, Lieberherr, M, Giese, G & Wunderlich, F (1998) Estradiol binding to cell surface raises cytosolic free calcium in T cells. FEBS Letters 422, 349–353.CrossRefGoogle ScholarPubMed
Benten, WPM, Lieberherr, M, Sekeris, CE & Wunderlich, F (1997) Testosterone induces Ca2+ influx via non-genomic surface receptors in activated T cells. FEBS Letters 407, 211–214.CrossRefGoogle ScholarPubMed
Benvenuti, S, Tanini, A, Fredianin, U, Bianchi, S, Masi, L, Casano, R, Bufalino, L, Serio, M & Brandi, ML (1991) Effects of ipriflavone on a clonal osteoblastic line. Journal of Bone and Mineral Research 6, 987–996.CrossRefGoogle Scholar
Blair, HC, Jordan, SE, Peterson, TG & Barnes, S (1996) Variable effects of tyrosine kinase inhibitors on avian osteoclastic activity and reduction of bone loss in ovariectomized rats. Journal of Cellular Biochemistry 61, 629–637.3.0.CO;2-A>CrossRefGoogle ScholarPubMed
Bodine, PVN, Henderson, RA, Green, J, Aronow, M, Owen, T, Stein, GS, Lian, JB & Komm, BS (1998) Estrogen receptor-a is developmentally regulated during osteoblast differentiation and contributes to selective responsiveness of gene expression. Endocrinology 139, 2048–2057.CrossRefGoogle Scholar
Brown, NM & Lamartiniere, CA (1995) Xenoestrogens alter mammary gland differentiation and cell proliferation in the rat. Environmental Health Perspectives 103, 708–713.Google ScholarPubMed
Carroll, KK (1975) Experimental evidence of dietary factors and hormone-dependent cancers. Cancer Research 35, 3374–3383.Google ScholarPubMed
Cassidy, A, Bingham, S & Setchell, K (1995) Biological effects of isoflavones in young women: importance of the chemical composition of soyabean products. British Journal of Nutrition 74, 587–601.CrossRefGoogle ScholarPubMed
Cassidy, A, Bingham, S & Setchell, KDR (1994) Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women. American Journal of Clinical Nutrition 60, 333–340.CrossRefGoogle Scholar
Cecchini, MG, Fleisch, H & Mühlbauer, RC (1997) Ipriflavone inhibits bone resorption in intact and ovariectomized rats. Calcified Tissue International 61, S9–S11.CrossRefGoogle ScholarPubMed
Chemopreventive Branch and Agent Development Committee (1996) Clinical development plan, genistein. Journal of Cellular Biochemistry 265, 114–126.Google Scholar
Connolly, JM, Liu, X-H & Rose, DP (1997) Effects of dietary menhaden oil, soy, and a cyclooxygenase inhibitor on human breast cancer cell growth and metastasis in nude mice. Nutrition and Cancer 29, 48–54.CrossRefGoogle Scholar
Constantinou, A, Kiguchi, K & Huberman, E (1990) Induction of differentiation and DNA strand breakage in human HL-60 and K-562 leukemia cells by genistein. Cancer Research 50, 2618–2624.Google ScholarPubMed
Constantinou, AL, Mehta, RG & Vaughan, A (1996) Inhibition of N-methyl-N-nitrosourea-induced mammary tumors in rats by the soybean isoflavones. Anticancer Research 16, 3293–3298.Google ScholarPubMed
Coward, L, Barnes, NC, Setchell, KDR & Barnes, S (1993) Genistein, daidzein, and their a-glycoside conjugates: antitumor isoflavones in soybean foods from American and Asian diets. Journal of Agricultural and Food Chemistry 41, 1961–1967.CrossRefGoogle Scholar
Cowley, SM, Hoare, S, Mosselman, S & Parker, MG (1997) Estrogen receptors alpha and beta form heterodimers on DNA. Journal of Biological Chemistry 272, 19858–19862.CrossRefGoogle ScholarPubMed
Crouse, JR, Terry, JG, Morgan, TM, McGill, BL, Davis, DH, King, T, Ellis, JE & Burke, GL (1998) Soy protein containing isoflavones reduces plasma concentrations of lipids and lipoproteins. Circulation 97, 816.Google Scholar
Dalu, A, Haskell, J and Lamartiniere, CA (1996) Dietary genistein inhibits protein tyrosine phosphorylation in the dorsolateral prostate of the rat. Proceedings of the Second International Symposium on the Role of Soy in Preventing and Treating Chronic Disease, p. 47. Abstr. no. 10.Google Scholar
Dees, C, Foster, JS, Ahamed, S & Wimalensa, J (1997) Dietary estrogens stimulate human breast cancer cells to enter the cell cycle. Environmental Health Perspectives 105, Suppl. 3633–636.Google ScholarPubMed
Dodge, JA, Glasebrook, AL, Magee, DE, Phillips, DL, Sato, M, Short, LL & Bryant, HU (1996) Environmental estrogens: Effects of cholesterol lowering and bone in the ovariectomized rat. Journal of Steroid Biochemistry and Molecular Biology 59, 155–161.CrossRefGoogle ScholarPubMed
Draper, CR, Edel, MJ, Dick, IM, Randall, AG, Martin, GB & Prince, RL (1997) Phytoestrogens reduce bone loss and bone resorption in oophorectomized rats. Journal of Nutrition 127, 1795–1799.CrossRefGoogle ScholarPubMed
Duncan, AM, Merz, BE, Xu, X, Underhill, KEW, Phipps, WR & Kurzer, MS (1998) Soy isoflavones do not exert hormonal effects in premenopausal women. FASEB Journal 12, A568.Google Scholar
Evans, BAJ, Griffiths, K & Morton, MS (1995) Inhibition of 5a-reductase in genital skin fibroblasts and prostate tissue by dietary lignans and isoflavonoids. Journal of Endocrinology 147, 295–302.CrossRefGoogle ScholarPubMed
Folman, Y & Pope, GS (1966) The interaction in the immature mouse of potent estrogens with coumestrol, genistein and other utero-vaginotrophic compounds of low potency. Journal of Endocrinology 34, 215–225.CrossRefGoogle ScholarPubMed
Foth, D & Cline, JM (1998) Effects of mammalian and plant estrogens on mammary glands and uteri of macaques. American Journal of Clinical Nutrition 68, 1413S–1417S.Google ScholarPubMed
Fotsis, T, Pepper, M, Adlercreutz, H, Gleischmann, G, Hase, T, Montesano, R & Schweigerer, L (1993) Genistein, a dietary-derived inhibitor of in vitro angiogenesis. Proceedings of the National Academy of Sciences, USA 90, 2690–2694.CrossRefGoogle ScholarPubMed
Franke, AA, Custer, LJ, Cerna, CM & Narala, KK (1994) Quantitation of phytoestrogens in legumes by HPLC. Journal of Agriculture and Food Chemistry 42, 1905–1913.CrossRefGoogle Scholar
Fujio, Y, Fumiko, Y, Takahashi, K & Shibata, N (1993) Responses of smooth muscle cells to platelet-derived growth factor are inhibited by herbimycin-A tyrosine kinase inhibitor+. Biochemical and Biophysical Research Communications 195, 79–83.CrossRefGoogle ScholarPubMed
Gaub, MP, Bellard, M, Scheuer, I, Chambon, P & Sasson-Corsi, P (1990) Activation of the ovalbumin gene by the estrogen receptor involves the fos-jun complex. Cell 63, 1267–1276.CrossRefGoogle ScholarPubMed
Geller, J, Sionit, L, Partido, C, Lingna, L, Tan, X, Youngkin, T, Nachtsheim, D & Hoffman, RM (1998) Genistein inhibits the growth of human-patient BPH and prostate cancer in histoculture. The Prostate 34, 75–79.3.0.CO;2-I>CrossRefGoogle ScholarPubMed
Gennari, C, Adami, S, Agnusdei, D, Bufalino, L, Cervetti, R, Crepaldi, G, Di Marco, C, Di Munno, O, Fantasia, L, Isaia, GC, Mazzuoli, GF, Ortolani, S, Passeri, M, Serni, U & Vecchiet, L (1997) Effect of chronic treatment with ipriflavone in postmenopausal women with low bone mass. Calcified Tissue International 61, S19–S22.CrossRefGoogle ScholarPubMed
Geynet, C, Millet, C, Truong, H & Baulier, EE (1972) Estrogens and antiestrogens. Hormone antagonists. Gynecologic Investigations 3, 2–29.Google Scholar
Gotoh, T, Yamada, K, Ito, A, Yin, H, Kataoka, T & Dohi, K (1998 a) Chemoprevention of N-nitroso-N-methylurea-induced rat mammary cancer by miso and tamoxifen, alone and in combination. Japanese Journal of Cancer Research 89, 487–495.CrossRefGoogle ScholarPubMed
Gotoh, T, Yamada, K, Yin, H, Ito, A, Kataoka, T & Dohi, K (1998 b) Chemoprevention of N-nitroso-N-methylurea-induced rat mammary carcinogenesis by soy foods or biochanin A. Japanese Journal of Cancer Research 80, 137–142.CrossRefGoogle Scholar
Graf, E & Eaton, JW (1993) Suppression of colonic cancer by dietary phytic acid. Nutrition and Cancer 19, 11–19.CrossRefGoogle ScholarPubMed
Greenstein, J, Kushi, L, Zheng, W, Fee, R, Campbell, D, Sellers, T & Folsom, A (1996) Risk of breast cancer associated with intake of specific foods and food groups. American Journal of Epidemiology 143, S36.Google Scholar
Gridley, DS, Kettering, JD, Slater, JM & Nutter, RL (1983) Modification of spontaneous mammary tumors in mice fed different sources of protein, fat, and carbohydrate. Cancer Letters 19, 133–146.CrossRefGoogle ScholarPubMed
Haggins, CJ, Martini, MC, Slavin, JL, Thomas, W & Bancisak, BB (1998) Soy supplementation does not affect hormone levels or menstrual cycle length in women with or without oral contraceptives. FASEB Journal 12, A568.Google Scholar
Hawrylewicz, EJ, Huang, HH & Blair, WH (1991) Dietary soybean isolate and methionine supplementation affect mammary tumor progression in rats. Journal of Nutrition 121, 1693–1698.CrossRefGoogle ScholarPubMed
Helmeste, DM & Tang, SW (1995) Tyrosine kinase inhibitors regulate serotonin uptake in platelets. European Journal of Pharmacology 280, R5–R7.CrossRefGoogle ScholarPubMed
Hendrich, S, Xu, X, Lu, Z, Dickerson, S, Cunnick, JE & Murphy, PA (1998) Human isoflavone bioavailability during seven days of soymilk feeding, and lack of isoflavone effect of natural killer cell activity. FASEB Journal 12, A874.Google Scholar
Higashi, K & Ogawara, H (1994) Daidzein inhibits insulin- or insulin-growth factor-1-mediated signaling in cell cycle progression of Swiss 3T3 cells. Biochimica et Biophysica Acta 1221, 29–35.CrossRefGoogle ScholarPubMed
Hirano, T, Oka, K & Akiba, M (1989) Antiproliferative effects of synthetic and naturally occurring flavonoids on tumor cells of the human breast carcinoma cell line, ZR-75-1. Research Communications in Chemical Pathology and Pharmacology 64, 69–78.Google ScholarPubMed
Hirayama, T (1979) Epidemiology of prostate cancer with special reference to the role of diet. National Cancer Institute Monograph 53, 149–155.Google Scholar
Hirayama, T (1986) A large scale cohort study on cancer risks by diet - with special reference to the risk reducing effects of green-yellow vegetable consumption. In Diet, Nutrition and Cancer, pp. 41–53 [Hayashi, Y, Nagao, M, Sugimara, T, Tokayama, S, Tomatis, L, Wattenberg, LW and Wagen, GN, editors]. Utrecht, The Netherlands: Tokyo/VNU Science PressGoogle ScholarPubMed
Hirohata, T, Shigematsu, T, Nomura, AMY, Normua, Y, Horie, A & Hirohata, I (1985) Occurrence of breast cancer in relation to diet and reproductive history: a case-control study in Fukuoka, Japan. National Cancer Institute Monographs 69, 187–190.Google ScholarPubMed
Hirose, K, Tajima, K, Hamajima, N, Inoue, M, Takezaki, T, Kuroisha, T, Yoshida, M & Tokudome, S (1985) A large-scale hospital-based case-control study of risk factors of breast cancers according to menopausal status. Japanese Journal of Cancer Research 86, 146–154.CrossRefGoogle Scholar
Hodgson, JM, Croft, KD, Puddey, IB, Mori, TA & Beillin, LJ (1996) Soybean isoflavonoids and their metabolic products inhibit in vitro lipoprotein oxidation in serum. Journal of Nutritional Biochemistry 7, 664–669.CrossRefGoogle Scholar
Hodgson, JM, Puddey, IB, Beillin, LJ, Mori, TA & Croft, KD (1998) Supplementation with isoflavonoid phytoestrogens does not alter serum lipid concentrations: a randomized controlled trial in humans. Journal of Nutrition 128, 728–732.CrossRefGoogle Scholar
Honoré, EK, Williams, JK, Anthony, MS & Clarkson, TB (1997) Soy isoflavones enhance vascular reactivity in atherosclerotic female macaques. Fertility and Sterility 67, 148–154.CrossRefGoogle ScholarPubMed
Hsieh, C-Y, Santell, RC, Haslam, SZ & Helferich, WG (1998) Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo. Cancer Research 58, 3833–3838.Google ScholarPubMed
Hsueh, AM & Park, H-S (1990) Quality of dietary protein and chemical carcinogenesis in rats. International News: Fats Oils Related Materials 1, 303.Google Scholar
Huff, MW, Hamilton, RMG & Carroll, KK (1977) Plasma cholesterol levels in rabbits fed low fat, cholesterol-free, semipurified diets: Effects of dietary proteins, protein hydrolysates and amino acid mixtures. Atherosclerosis 28, 187–195.CrossRefGoogle ScholarPubMed
Imoto, M, Yamashita, T, Sawa, T, Kurasawa, S, Naganawa, H, Takeuchi, T, Bao- quan, Z & Umezawa, K (1988) Inhibition of cellular phosphatidylinositol turnover by psi-tectorigenin. FEBS Letters 230, 43–46.CrossRefGoogle ScholarPubMed
Ingram, D, Sanders, K, Kolybaba, M & Lopez, D (1997) Phytoestrogens and breast cancer - a case control study. Lancet 350, 990–994.CrossRefGoogle Scholar
Jayo, MJ, Anthony, MS, Register, TC, Rankin, SE, Vest, T & Clarkson, TB (1996) Dietary soy isoflavones and bone loss: a study in ovariectomized monkeys. Journal of Bone and Mineral Research 11(Suppl. 1): 228S.Google Scholar
Jing, Y, Nakaya, K & Han, R (1993) Differentiation of promyelocytic leukemia cells HL-60 induced by daidzein in vitro and in vivo. Anticancer Research 13, 1049–1054.Google ScholarPubMed
Kamei, H, Koide, T, Hashimoto, Y, Kojima, T, Umeda, T & Hasegawa, M (1997) Tumor cell growth-inhibiting effects of melanoidins extracted from miso and soy sauce. Cancer Biotherapy & Radiopharmaceuticals 12, 405–409.CrossRefGoogle ScholarPubMed
Kennedy, AR & Manzone, H (1995) Effects of protease inhibitors on levels of proteolytic activity in normal and premalignant cells and tissues. Journal of Cellular Biochemistry 22, Suppl., 188–194.CrossRefGoogle ScholarPubMed
King, RA & Bursill, DB (1998) Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans. American Journal of Clinical Nutrition 67, 867–872.CrossRefGoogle ScholarPubMed
Kirk, EA, Sutherland, P, Wang, SA, Chait, A & LeBoeuf, RC (1998) Dietary isoflavones reduce plasma cholesterol and atherosclerosis in C57BL/6 mice but not LDL receptor-deficient mice. Journal of Nutrition 128, 954–959.CrossRefGoogle Scholar
Koratkar, R & Rao, AV (1997) Effect of soy bean saponins on azoxymethane-induced preneoplastic lesions in the colon of mice. Nutrition and Cancer 27, 206–209.CrossRefGoogle ScholarPubMed
Kuiper, GGJM, Carlsson, B, Grandien, K, Enmark, E, Häggblad, J, Nilsson, S & Gustafsson, JÅ (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138, 863–870.CrossRefGoogle ScholarPubMed
Kuiper, GGJM, Enmark, E, Pelto-Huikko, M, Nilsson, S & Gustafsson, JÅ (1996) Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proceedings of the National Academy of Sciences, USA 93, 5925–5930.CrossRefGoogle ScholarPubMed
Kuo, S-M (1996) Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells. Cancer Letters 110, 41–48.CrossRefGoogle ScholarPubMed
Kuruvilla, A, Putcha, G, Poulos, E & Shearer, WT (1993) Tyrosine phosphorylation of phospholipase C concomitant with its activation by platelet-activating factor in a human B cell line. Journal of Immunology 151, 637–648.CrossRefGoogle Scholar
Kyle, E, Neckers, L, Takimoto, C, Curt, G & Bergan, R (1997) Genistein-induced apoptosis of prostate cancer cells is preceded by a specific decrease in focal adhesion kinase activity. Molecular Pharmacology 51, 193–200.CrossRefGoogle ScholarPubMed
Lamartiniere, CA, Moore, JB, Brown, NM, Thompson, R, Hardin, MJ & Barnes, S (1995) Genistein suppresses mammary cancer in rats. Carcinogenesis 16, 2833–2840.CrossRefGoogle ScholarPubMed
Le Mellay, V, Grosse, B & Lieberherr, M (1997) Phospholipase C β and membrane action of calcitriol and estradiol. Journal of Biological Chemistry 272, 11902–11907.CrossRefGoogle ScholarPubMed
Lee, HP, Gourley, L, Duffy, SW, Esteve, J & Day, NE (1991) Dietary effects on breast-cancer risk in Singapore. Lancet 337, 1197–1200.CrossRefGoogle ScholarPubMed
Lees, C & Ginn, TA (1998) Soy protein isolate diet does not prevent increased cortical bone turnover in ovariectomized macaques. Calcified Tissue International 62, 557–558.CrossRefGoogle Scholar
Linassier, C, Pierre, M, Le, Peco|J-B & Pierre, J (1990) Mechanism of action in NIH-3T3 cells of genistein, an inhibitor of EGF receptor tyrosine kinase activity. Biochemical Pharmacology 39, 187–193.CrossRefGoogle ScholarPubMed
Lu, L-J, Anderson, KE, Grady, JJ & Nagamani, M (1996 a) Effects of soy consumption for one month on steroid hormones in postmenopausal women: implications for breast cancer risk reduction. Cancer Epidemiology, Biomarkers and Prevention 5, 63–70.Google Scholar
Lu, L-J, Anderson, KE, Grady, JJ & Nagamani, M (1996 b) Effects of one month soy consumption on circulating steroids in men. Proceedings of the American Association for Cancer Research 37, 270.Google Scholar
Machelon, V, Nomé, F, Grosse, B & Lieberherr, M (1996) Progesterone triggers rapid transmembrane calcium influx and|or calcium mobilization from endoplasmic reticulum, via a pertussis-insensitive G-protein in granulosa cells in relation to luteinization process. Journal of Cellular Biochemistry 61, 619–628.3.0.CO;2-A>CrossRefGoogle ScholarPubMed
McMichael-Phillips, DF, Harding, C, Morton, M, Roberts, ST, Howell, A, Potten, CS & Bundred, NJ (1998) The effects of soy-protein supplementation on epithelial proliferation in the histologically normal human breast. American Journal of Clinical Nutrition 68, Suppl., 1431S–1436S.CrossRefGoogle ScholarPubMed
McNicol, A (1993) The effects of genistein on platelet function are due to thromboxane receptor antagonism rather than inhibition of tyrosine kinase. Prostaglandins, Leukotrienes and Essential Fatty Acids 48, 379–384.CrossRefGoogle ScholarPubMed
Mäkelä, S, Davis, VL, Tally, WC, Korkman, J, Sala, L, Vinko, R & Korach, KS (1994) Dietary estrogens act through estrogen receptor-mediated processes and show no antiestrogenicity in cultured breast cancer cells. Environmental Health Perspectives 102, 572–578.CrossRefGoogle ScholarPubMed
Mäkelä, SI, Pylkkänen, LH, Santti, RSS & Adlercreutz, H (1995) Dietary soybean may be antiestrogenic in male mice. Journal of Nutrition 125, 437–445.Google ScholarPubMed
Makishima, M, Honma, Y, Hozumi, M, Nagata, N & Motoyoshi, K (1993) Differentiation of human monoblastic leukemia U837 cells induced by inhibitors of myosin light chain kinase and prevention of differentiation by granulocyte macrophage colony stimulating factor. Biochimica et Biophysica Acta 1176, 245–249.CrossRefGoogle Scholar
Markiewicz, L, Garey, J, Adlercreutz, H & Gurpide, E (1993) In vitro bioassays of non-steroidal phytoestrogens. Journal of Steroid Biochemistry and Molecular Biology 45, 399–405.CrossRefGoogle ScholarPubMed
Martin, ME, Haourigui, M, Pelissero, C, Benassayag, C & Nunez, EA (1996) Interactions between phytoestrogens and human sex steroid binding protein. Life Sciences 58, 429–436.CrossRefGoogle ScholarPubMed
Martin, PM, Horwitz, KB, Ryan, DS & McGuire, WL (1978) Phytoestrogen interaction with estrogen receptors in human breast cancer cells. Endocrinology 103, 1860–1867.CrossRefGoogle ScholarPubMed
Matsukawa, Y, Marui, N, Sakai, T, Satomi, Y, Yoshida, M, Matsumoto, K, Nishimo, H & Aoike, A (1993) Genistein arrests cell cycle progression at G2-M. Cancer Research 53, 1328–1331.Google ScholarPubMed
Mayr, U, Butsch, A & Schneider, S (1992) Validation of two in vitro test systems for estrogenic activities with zearalenone, phytoestrogens and cereal extracts. Toxicology 74, 135–149.CrossRefGoogle ScholarPubMed
Meeker, DR & Kesten, HD (1941) Effect of high protein diets on experimental atherosclerosis of rabbits. Archives of Pathology 31, 147–162.Google Scholar
Menon, LG, Kuttan, R, Nair, MG, Chang, Y-C & Kuttan, G (1998) Effect of isoflavones genistein and daidzein in the inhibition of lung metastasis in mice induced by B16F-10 melanoma cells. Nutrition and Cancer 30, 74–77.CrossRefGoogle ScholarPubMed
Messina, M (1995) Isoflavone intakes by Japanese were overestimated (letter to the editor). American Journal of Clinical Nutrition 62, 645.CrossRefGoogle Scholar
Messina, M, Persky, V, Setchell, KDR & Barnes, S (1994) Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutrition and Cancer 21, 113–131.CrossRefGoogle Scholar
Messina, MJ & Barnes, S (1991) The role of soy products in reducing risk of cancer. Journal of the National Cancer Institute 83, 541–546.CrossRefGoogle ScholarPubMed
Migliaccio, S, Davis, VL, Gibson, MK, Gray, TK & Korach, KS (1992) Estrogens modulate the responsiveness of osteoblast-like cells (ROS 17|2.8) stably transfected with estrogen receptor. Endocrinology 130, 2617–2624.CrossRefGoogle ScholarPubMed
Miksicek, RJ (1993) Commonly occurring plant flavonoids have estrogenic activity. Molecular Pharmacology 44, 37–43.Google ScholarPubMed
Miksicek, RJ (1994) Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor. Journal of Steroid Biochemistry and Molecular Biology 49, 153–160.CrossRefGoogle ScholarPubMed
Mitchell, JH & Collins, AR (1998) Effects of soy milk supplement on oxidative DNA damage in men: a pilot study. COST 916 WorkshopApril 17-18The Netherlands.Google Scholar
Moorghen, M, Orde, M, Finney, KJ, Appleton, DR & Watson, AJ (1998) Sulindac enhances cell proliferation in DMH-treated mouse colonic mucosa. Cell Proliferation 31, 59–70.CrossRefGoogle ScholarPubMed
Morton, MS, Matos-Ferreira, A, Abranches-Monteiro, L, Correia, R, Blacklock, N, Chan, PSF, Cheng, C, Lloyd, S, Chiehping, W & Griffiths, K (1997) Measurement and metabolism of isoflavonoids and lignans in human male. Cancer Letters 114, 145–151.CrossRefGoogle ScholarPubMed
Murillo, G, Singletary, KW, Kamath, SK & Arjmandi, BH (1998) The antitumorigenic properties of ipriflavone and genistein in rat mammary tissues. FASEB Journal 12, 828A.Google Scholar
Murphy, CT, Kellie, S & Westwick, J (1993) Tyrosine-kinase activity in rabbit platelets stimulated with platelet- activating factor. The effect of inhibiting tyrosine kinase with genistein on platelet-signal-molecule elevation and functional responses. European Journal of Biochemistry 216, 639–651.CrossRefGoogle ScholarPubMed
Murrill, WB, Brown, NM, Zhang, J-X, Manzolillo, PA, Barnes, S & Lamartiniere, CA (1996) Prepubertal genistein exposure suppresses mammary cancer and enhances gland differentiation in rats. Carcinogenesis 17, 1451–1457.CrossRefGoogle ScholarPubMed
Nagata, C, Takatsuka, N, Kurisu, Y & Shimizu, H (1998) Decreased serum total cholesterol concentration is associated with high intake of soy products in Japanese men and women. Journal of Nutrition 128, 209–213.CrossRefGoogle ScholarPubMed
Naik, HR, Lehr, JE & Pienta, KJ (1994) An in vitro and in vivo study of antitumor effects of genistein on hormone refractory prostate cancer. Anticancer Research 14, 2617–2620.Google Scholar
Nemere, I (1995) Non-genomic effects of 1, 25-dihydroxyvitamin D3: potential relation of a plasmalemmal receptor to the acute enhancement of intestinal calcium transport in chick. Journal of Nutrition 125, 1695S–1698S.Google Scholar
Nemere, I (1996) Apparent non-nuclear regulation of intestinal phosphate transport: effects of 1, 25-dihydroxyvitamin D3, 24, 25- dihydroxyvitamin D3, and 25-hydroxyvitamin D3. Endocrinology 137, 2254–2261.CrossRefGoogle Scholar
Nestel, PJ, Yamashita, T, Sasahara, T, Pomeroy, S, Dart, A, Komesaroff, P, Owen, A & Abbey, M (1997) Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women. Arterisclerosis, Thrombosis and Vascular Biology 17, 3392–3398.CrossRefGoogle Scholar
Nomura, A, Henderson, BE & Lee, J (1978) Breast cancer and diet among the Japanese in Hawaii. American Journal of Clinical Nutrition 31, 2025–2030.CrossRefGoogle ScholarPubMed
Oishi, K, Okada, K, Yoshida, O, Yamabe, H, Ohno, Y, Hayes, RB & Schroeder, FH (1988) A case control study of prostatic cancer with reference to dietary habits. Prostate 12, 179–190.CrossRefGoogle ScholarPubMed
Okura, A, Arakawa, H, Oka, H, Yoshinari, T & Monden, Y (1988) Effect of genistein on topoisomerase activity and the growth of val 12 H-ras-transformed NIH3T3 cells. Biochemical and Biophysical Research Communications 157, 183–189.CrossRefGoogle Scholar
Olsson, H, Landin-Olsson, M & Gullberg, B (1983) Retrospective assessment of menstrual cycle length in patients with breast cancer, in patients with benign breast disease, and in women without breast disease. Journal of the National Cancer Institute 70, 17–20.Google ScholarPubMed
Onoe, Y, Miyaura, C, Ohta, H, Nozawa, S & Suda, T (1997) Expression of estrogen receptor b in rat bone. Endocrinology 138, 4509–4512.CrossRefGoogle Scholar
Paech, K, Webb, P, Kuiper, GG, Nilsson, S, Gustafsson, J, Kushner, PJ & Scanlan, TS (1997) Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Science 277, 1508–1510.CrossRefGoogle ScholarPubMed
Pagliacci, MC, Smacchia, M, Migliorati, G, Grignana, F, Riccardi, C & Nicoletti, I (1994) Growth-inhibitory effects of the natural phytoestrogen genistein in MCF-7 human breast cancer cells. European Journal of Cancer 30A, 1675–1682.CrossRefGoogle ScholarPubMed
Pansini, F, Bonaccorsi, G, Albertazzi, P, Costantino, D, Valerio, A, Negri, C, Ferrazzini, S, Bonocuore, I, De Aloysio, D, Fontana, A, Pansini, N & Mollica, G (1997) Soy phytoestrogens and bone. Annual Meeting of the North American Menopause Society, p. 44, Abstr. no. 97.061Google Scholar
Peterson, G & Barnes, S (1991) Genistein inhibits of the growth of human breast cancer cells: independence from estrogen receptors and the multi-drug resistance gene. Biochemical and Biophysical Research Communications 179, 661–667.CrossRefGoogle ScholarPubMed
Peterson, G & Barnes, S (1993) Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor autophosphorylation. The Prostate 22, 335–345.CrossRefGoogle ScholarPubMed
Peterson, G & Barnes, S (1996) Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cells. Cell Growth and Differentiation 7, 1345–1351.Google ScholarPubMed
Peterson, TG, Kim, H & Barnes, S (1998) Genistein may inhibit the growth of human mammary epithelial (HME) cell by augmenting by transforming growth factor beta (TGFβ) signaling. American Journal of Clinical Nutrition 68, Suppl., 1527S–1528S.Google Scholar
Petrakis, NL, Barnes, S, King, EB, Lowenstein, J, Wiencke, J, Lee, MM, Miike, R, Kirk, M & Coward, L (1996) Stimulatory influence of soy protein isolate on breast secretion in pre- and postmenopausal women. Cancer Epidemiology, Biomarkers & Prevention 5, 785–794.Google ScholarPubMed
Pettersson, K, Grandien, K, Kuiper, GG & Gustafsson, JA (1997) Mouse estrogen receptor beta forms estrogen response element-binding heterodimers with estrogen receptors alpha. Molecular Endocrinology 11, 1486–1496.Google Scholar
Picotto, G, Massheimer, V & Boland, R (1996) Acute stimulation of intestinal cell calcium influx induced by 17β-oestradiol via the cAMP messenger system. Molecular and Cellular Endocrinology 119, 129–134.CrossRefGoogle ScholarPubMed
Pienta, KJ & Esper, PS (1993) Risk factors for prostate cancer. Annals of Internal Medicine 118, 793–803.CrossRefGoogle ScholarPubMed
Pollard, M & Luckert, PH (1997) Influence of isoflavones in soy protein isolates on development of induced prostate-related cancers in L-W rats. Nutrition and Cancer 28, 41–45.CrossRefGoogle ScholarPubMed
Potter, SM, Baum, JA, Teng, H, Stillman, RJ & Erdman, JW (1998) Soy protein and isoflavones: Their effects on blood lipids and bone density in postmenopausal women. American Journal of Clinical Nutrition 68, 1375S–1379S.CrossRefGoogle ScholarPubMed
Potter, SM, Jimenez-Flores, R, Pollack, J-A, Lone, TA & Berber- Jiminez, MD (1993) Protein-saponin interaction and its influence on blood lipids. Journal of Agricultural and Food Chemistry 41, 1287–1291.CrossRefGoogle Scholar
Ramakrishna, MBV, Mital, BK, Gupta, KC & Sand, NK (1989) Determination of phenolic acids in different soybean varieties by reversed phase high performance liquid chromatography. Journal of Food Science and Technology 26, 154–155.Google Scholar
Rao, AV & Janezic, SA (1992) The role of dietary phytosterols in colon carcinogenesis. Nutrition and Cancer 18, 43–52.CrossRefGoogle ScholarPubMed
Rauth, S, Kichina, J & Green, A (1997) Inhibition of growth and induction of differentation of metastatic melanoma cells in vitro by genistein: chemosensitivity is regulated by cellular p53. British Journal of Cancer 75, 1559–1566.CrossRefGoogle Scholar
Register, TC, Anthony, M, Jayo, MJ & Williams, JK (1997) Effects of 17β-oestradiol and consumption of phytoestrogen-rich soy or casein|lactalbumin-based diets on serum chemistries in ovariectomized female macaques. Journal of Bone and Mineral Research 12, Suppl., 350S.Google Scholar
Ross, RK, Bernstein, LA, Lobo, RA, Shimizu, H, Stanczyk, FZ, Pike, MC & Henderson, BE (1992) 5-alpha-reductase activity and risk of prostate cancer among Japanese and US white and black males. Lancet 339, 887–889.CrossRefGoogle ScholarPubMed
Ruiz-Larrea, MB, Mohan, AR, Paganga, G, Miller, NJ, Bolwell, GP & Rice-Evans, CA (1997) Antioxidant activity of phytoestrogenic isoflavones. Free Radical Research 26, 63–70.CrossRefGoogle ScholarPubMed
Santell, RC, Chang, YC, Nair, MG & Helferich, WG (1997) Dietary genistein exerts estrogen effects upon the uterus, mammary gland and the hypothalmic|pituitary axis in rats. Journal of Nutrition 127, 263–269.Google ScholarPubMed
Santell, RC, Kieu, N & Helferich, WG (1998) The effect of genistein upon estrogen receptor negative human breast cancer cell growth in vitro and in vivo. FASEB Journal 12, 655A.Google Scholar
Santibáñez, JF, Navarro, A & Martinez, J (1997) Genistein inhibits proliferation and in vitro invasive potential of human prostatic cancer cell lines. Anticancer Research 17, 1199–1204.Google ScholarPubMed
Sathyamoorthy, N & Wang, TTY (1997) Differential effects of dietary phytoestrogen daidzein and equol on human breast cancer MCF-7 cells. European Journal of Cancer 33, 2384–2389.CrossRefGoogle ScholarPubMed
Schleicher, T, Zheng, M, Zhang, M & Lamartiniere, CA (1998) Genistein inhibition of prostate cancer cell growth and metastasis in vivo. American Journal of Clinical Nutrition 68, Suppl., 1526S.Google Scholar
Scholar, EM & Toewa, ML (1994) Inhibition of invasion of murine mammary carcinoma cells by the tyrosine kinase inhibitor genistein. Cancer Letters 87, 159–162.CrossRefGoogle ScholarPubMed
Severson, KJ, Nomura, AMY, Grove, JS & Stemmermann, GN (1989) A prospective study of demographics, diet, and prostate cancer among men of Japanese ancestry in Hawaii. Cancer Research 49, 1857–1860.Google ScholarPubMed
Shao, Z-M, Alpaugh, ML, Fontana, JA & Barsky, SH (1998) Genistein inhibits proliferation similarly in estrogen receptor-positive and negative human breast carcinoma cell lines characterized by P21WAF1|CIPI induction, G2|M arrest, and apoptosis. Journal of Cellular Biochemistry 69, 44–54.3.0.CO;2-V>CrossRefGoogle ScholarPubMed
Shibata, A, Whittemore, AS, Imai, K, Kolonel, LN, Wu, AH, John, EM, Stamey, TA & Paggenbarger, RS (1997) Serum levels of prostate specific antigen among Japanese-American and native Japanese men. Journal of the National Cancer Institute 89, 1716–1720.CrossRefGoogle ScholarPubMed
Shimokado, K, Umezawa, K & Ogata, J (1995) Tyrosine kinase inhibitors inhibit multiple steps of the cell cycle of vascular smooth muscle cells. Experimental Cell Research 220, 266–273.CrossRefGoogle ScholarPubMed
Shimokado, K, Yokota, T, Umezawa, K, Sasaguri, T & Ogata, J (1994) Protein tyrosine kinase inhibitors chemotaxis of vascular smooth muscle cells. Arteriosclerosis and Thrombosis 14, 973–981.CrossRefGoogle ScholarPubMed
Sonn, TT, Hendrich, S & Murphy, PA (1997) Estrogenic activity of glycitein, a soy isoflavone. FASEB Journal 11, 601A.Google Scholar
Spinozzi, F, Pagliacci, MC, Migliorati, G, Moraca, R, Grionani, F, Riccardi, C & Nicoletti, I (1994) The natural tyrosine kinase inhibitor genistein produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. Leukemia Research 18, 431–439.CrossRefGoogle ScholarPubMed
Stephens, FO (1997) Phytoestrogens and prostate cancer: possible preventive role. Medical Journal of Australia 167, 138–140.CrossRefGoogle ScholarPubMed
Sugano, M & Koba, K (1993) Dietary protein and lipid metabolism: a multifunctional effect. Annals of the New York Academy of Sciences 676, 215–222.CrossRefGoogle ScholarPubMed
Thorburn, J & Thorburn, T (1994) The tyrosine kinase inhibitor, genistein, prevents a-adrenergic-induced cardiac muscle cell hypertrophy by inhibiting activation of the Ras-MAP kinase signalling pathway. Biochemical and Biophysical Research Communications 202, 1586–1591.CrossRefGoogle Scholar
Tobe, H, Komiyama, O, Komiyama, Y & Maruyama, HB (1997) Daidzein stimulation of bone resorption in pit formation assay. Bioscience, Biotechnology and Biochemistry 61, 370–371.CrossRefGoogle ScholarPubMed
Tovar-Palacio, C, Potter, SM, Hafermann, JC & Shay, NF (1998) Intake of soy protein and soy protein extracts influences lipid metabolism and hepatic gene expression in gerbils. Journal of Nutrition 128, 839–842.CrossRefGoogle ScholarPubMed
Troll, W, Wiesner, R, Shellabarger, CJ, Hotzman, S & Stone, JP (1980) Soybean diet lowers breast tumor incidence in irradiated rats. Carcinogenesis 1, 469–472.CrossRefGoogle ScholarPubMed
Tsutsumi, N (1995) Effect of coumestrol on bone metabolism in organ culture. Biological and Pharmaceutical Bulletin 18, 1012–1015.CrossRefGoogle Scholar
Umayahara, Y, Kawamori, R, Watada, H, Imano, E, Iwama, N, Morishima, T, Yamasaki, Y, Kajimoto, Y & Kamada, T (1994) Estrogen regulation of the insulin-like growth factor 1 gene transcription involves an AP-1 enhancer. Journal of Biological Chemistry 269, 16433–16442.CrossRefGoogle ScholarPubMed
Wang, H-j & Murphy, PA (1994) Isoflavone content in commercial soybean foods. Journal of Agricultural and Food Chemistry 42, 1666–1673.CrossRefGoogle Scholar
Wang, TY, Sathyamoorthy, N & Phang, JM (1996) Molecular affects of genistein on estrogen receptor mediated pathways. Carcinogenesis 17, 271–275.CrossRefGoogle Scholar
Wang, W, Higuchi, CM & Zhang, R (1997) Individual and combinatory effects of soy isoflavones on the in vitro potentiation of lymphocyte activation. Nutrition and Cancer 29, 29–34.CrossRefGoogle ScholarPubMed
Wang, Y, Heston, DWD & Fair, WB (1995) Soy isoflavones decrease the high-fat promoted growth of human prostate cancer. Results of in vivo and animal studies. Journal of Urology 153, Abstr. no. 161.Google Scholar
Watson, CS, Pappas, TC & Gametchu, B (1995) The other estrogen receptor in the plasma membrane: implications for the actions of environmental estrogens. Environmental Health Perspectives 103, Suppl., 41–50.Google ScholarPubMed
Wei, H, Wei, L, Frenkel, K, Bowen, R & Barnes, S (1993) Inhibition of tumor promoter-induced hydrogen peroxide formation in vitro and in vivo by genistein. Nutrition and Cancer 20, 1–12.CrossRefGoogle ScholarPubMed
Williams, JP, Jordan, SE, Barnes, S & Blair, HC (1998) Tyrosine kinase inhibitor effects on osteoclastic acid transport. American Journal of Clinical Nutrition 68, 1369S–1374S.CrossRefGoogle ScholarPubMed
Weisz, A & Rosales, R (1990) Identification of an estrogen response element upstream of the human c-fos gene that binds the estrogen receptor and the AP-1 transcription factor. Nucleic Acids Research 18, 5097–5106.CrossRefGoogle ScholarPubMed
Witztum, JL & Steinberg, D (1991) Role of oxidized low density lipoprotein in atherogenesis. Journal of Clinical Investigation 88, 1785–1792.CrossRefGoogle ScholarPubMed
Wrensch, MR, Petrakis, NL, King, EB, Mike, R, Mason, L, Chew, KL, Lee, MM, Ernster, VL, Hilton, JF, Schweitzer, R, Goodson, WH & Hunt, TK (1991) Breast cancer incidence in women with abnormal cytology in nipple aspirates of breast fluid. American Journal of Epidemiology 135, 130–141.CrossRefGoogle Scholar
Wu, A & Pike, MC (1995) Dietary soy protein and hormonal status. American Journal of Clinical Nutrition 62, 151–152.CrossRefGoogle ScholarPubMed
Wu, AH, Ziegler, RG, Horn-Ross, PL, Nomura, AMY, West, DW, Kolonel, L, Rosenthal, JF, Hoover, RN & Pike, MC (1996) Tofu and risk of breast cancer in Asian-Americans. Cancer Epidemiology, Biomarkers, and Prevention 5, 901–906.Google ScholarPubMed
Wu, AH, Ziegler, RG, Horn-Ross, PL, Nomura, AMY, West, DW, Kolonel, L, Rosenthal, JF, Hoover, RN & Pike, MC (1998) Soy intake and risk of breast cancer in Asians and Asian Americans. American Journal of Clinical Nutrition 68, 1437S–1443S.CrossRefGoogle ScholarPubMed
Xu, X, Harris, KS, Wang, H-J, Murphy, PA & Hendrich, S (1995) Bioavailability of soybean isoflavones depends upon gut microflora in women. Journal of Nutrition 125, 2307–2315.CrossRefGoogle ScholarPubMed
Xu, X, Wang, HJ, Murphy, PA, Cook, L & Hendrich, S (1994) Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women. Journal of Nutrition 124, 825–832.CrossRefGoogle ScholarPubMed
Yan, L, Yee, JA, Li, D & McGuire, MH (1998) Effect of dietary supplementation of isoflavones on pulmonary metastasis of melanoma cells in mice. FEBS Journal 12, 829A.Google Scholar
Yan, L, Yee, JA, McGuire, MH & Graef, GL (1997) Effect of dietary supplementation of soybeans on experimental metastasis of melanoma cells in mice. Nutrition and Cancer 29, 1–8.CrossRefGoogle ScholarPubMed
Yanighara, K, Ito, A, Toge, T & Numoto, M (1993) Antiproliferative effect of isoflavones on human cancer cell lines established from the gastrointestinal tract. Cancer Research 53, 5815–5821.Google Scholar
Yatani, R, Kusano, I, Shiraishi, T, Hayashi, T & Stemmerman, GN (1989) Latent prostatic carcinoma: pathological and epidemiological aspects. Japanese Journal of Clinical Oncology 19, 319–326.Google ScholarPubMed
Yuan, J-M, Wang, Q-S, Ross, RK, Henderson, BE & Yu, MC (1995) Diet and breast cancer in Shanghai and Tianjin, China. British Journal of Cancer 71, 1353–1358.CrossRefGoogle ScholarPubMed
Yuan, J-M, Yu, MC, Ross, RK, Gao, Y-T & Henderson, BE (1988) Risk factors for breast cancer in Chinese women in Shanghai. Cancer Research 48, 1949–1953.Google ScholarPubMed
Zava, DT & Duwe, G (1997) Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro. Nutrition and Cancer 27, 31–40.CrossRefGoogle ScholarPubMed
Zhang, JX, Hallmans, G, Landstrom, M, Bergh, A, Damber, J-E, Aman, P & Adlercreutz, H (1997 a) Soy and rye diets inhibit the development of Dunning R3327 prostatic adenocarcinoma in rats. Cancer Letters 114, 313–314.CrossRefGoogle ScholarPubMed
Zhang, R, Li, Y & Wang, W (1997 b) Enhancement of immune function in mice fed high doses of soy daidzein. Nutrition and Cancer 29, 24–28.CrossRefGoogle ScholarPubMed
Zhou, J-R, Mukherjee, P, Clinton, SK & Blackburn, GL (1998) Soybean components inhibit the growth of human prostate cancer cell line LNCaP in SCID mice via alteration in cell apoptosis, angiogenesis and proliferation. FASEB Journal 12, 658A.Google Scholar