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Association between palliative care and the rate of advanced care planning: A systematic review

Published online by Cambridge University Press:  27 November 2019

Shahar Koffler Open the ORCID record for Shahar Koffler [Opens in a new window] ,
Yishai Mintzker  and
Ayelet Shai
Shahar Koffler*
Affiliation:
Azriely Faculty of Medicine, Bar Ilan University, Zafed, Israel
Yishai Mintzker
Affiliation:
Azriely Faculty of Medicine, Bar Ilan University, Zafed, Israel Department of Family Medicine, Maccabbi Health Care Services, Tel Aviv, Israel
Ayelet Shai
Affiliation:
Azriely Faculty of Medicine, Bar Ilan University, Zafed, Israel Department of Oncology, Galilee Medical Center, Nahariya, Israel
*
Author for correspondence: Shahar Koffler, Azriely Faculty of Medicine, Bar Ilan University, Zafed, Israel. E-mail: shaharkoffler@gmail.com
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Abstract

Objective

Advanced care planning (ACP) is central to patients' dignity and autonomy; however, in many countries it is underutilized. Studies that tested the effects of palliative care (PC) often included the rate of documented ACP as a secondary end point. We aimed to assess the contribution of PC to the rate of ACP among terminally ill patients by systematically reviewing relevant clinical trials.

Method

PUBMED and “Cochrane trials” databases were screened for clinical trials published until October 2017 that compared the addition of PC to standard treatment and that had ACP as a primary or a secondary end point. Studies were assessed for validity by three investigators using the Cochrane Collaboration tool and the ROBINS-I tool for randomized controlled trials (RCTs) and for cohort studies, respectively.

Results

Twenty-six trials with 37,924 patients were included. Four were RCTs, nine were cohort studies, and 12 were cross-sectional studies. Randomized trials had the lowest risk of bias. There was a positive correlation between the addition of PC and ACP in 25 studies, among them four randomized trials.

Significance of results

In this systematic review, PC was associated with improvement in the rate of ACP. Understanding the significant effect of PC on the completion of ACP is an additional emphasis on the importance of this treatment among terminally ill patients.

Keywords

Advanced care planningCancerDNRPalliative careTerminally ill
Type
Review Article
Information
Palliative & Supportive Care , Volume 18 , Issue 5 , October 2020 , pp. 589 - 601
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Copyright
Copyright © Cambridge University Press 2019

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Footnotes

*

These two authors contributed equally to this work.

References

Alsirafy, SA, Mohammed, AA, Al-Zahrani, AS, et al. (2015) The relation between the timing of palliative care and the frequency and timing of do-not-resuscitate orders among cancer deaths in a tertiary care hospital. American Journal of Hospice and Palliative Medicine 32(5), 544–548. https://doi.org/10.1177/1049909114529014CrossRefGoogle ScholarPubMed
Bailey, FA, Williams, BR, Woodby, LL, et al. (2014) Intervention to improve care at life's end in inpatient settings: The BEACON trial. Journal of General Internal Medicine 29(6), 836–843. https://doi.org/10.1007/s11606-013-2724-6CrossRefGoogle ScholarPubMed
Bhatraju, P, Friedenberg, AS, Uppal, A, et al. (2014) Factors associated with utilization of an inpatient palliative care consultation service in an urban public hospital. American Journal of Hospice and Palliative Medicine 31(6), 641–644. https://doi.org/10.1177/1049909113502845CrossRefGoogle Scholar
Billings, JA (2000) Recent advances: Palliative care. BMJ 321(7260), 555–558.CrossRefGoogle ScholarPubMed
Buchanan, RJ, Choi, M, Wang, S, et al. (2004) End-of-life care in nursing homes: Residents in hospice compared to other end-stage residents. Journal of Palliative Medicine 7(2), 221–232. https://doi.org/10.1089/109662104773709341CrossRefGoogle ScholarPubMed
Chen, CY, Thorsteinsdottir, B, Cha, SS, et al. (2015) Health care outcomes and advance care planning in older adults who receive home-based palliative care: A pilot cohort study. Journal of Palliative Medicine 18(1), 38–44. https://doi.org/10.1089/jpm.2014.0150CrossRefGoogle ScholarPubMed
De Gendt, C, Bilsen, J, Stichele, RV, et al. (2013) Advance care planning and dying in nursing homes in Flanders, Belgium: A nationwide survey. Journal of Pain and Symptom Management 45(2), 223–234. https://doi.org/10.1016/j.jpainsymman.2012.02.011CrossRefGoogle ScholarPubMed
Engelhardt, JB, McClive-Reed, KP, Toseland, RW, et al. (2006) Effects of a program for coordinated care of advanced illness on patients, surrogates, and healthcare costs: A randomized trial. The American Journal of Managed Care 12(2), 93–100.Google ScholarPubMed
Ferrell, B, Sun, V, Hurria, A, et al. (2015) Interdisciplinary palliative care for patients with lung cancer. Journal of Pain and Symptom Management 50(6), 758–767. https://doi.org/10.1016/j.jpainsymman.2015.07.005CrossRefGoogle ScholarPubMed
Ferrell, BR, Temel, JS, Temin, S, et al. (2017) Integration of palliative care into standard oncology care: American society of clinical oncology clinical practice guideline update. Journal of Clinical Oncology 35(1), 96–112. https://doi.org/10.1200/JCO.2016.70.1474CrossRefGoogle ScholarPubMed
Haun, MW, Estel, S, Rücker, G, et al. (2017) Early palliative care for adults with advanced cancer. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD011129.pub2Google ScholarPubMed
Higgins, JPT, Altman, DG, Gøtzsche, PC, et al. (2011) The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 343, d5928.CrossRefGoogle ScholarPubMed
Huang, K-S, Wang, S-H, Chuah, S-K, et al. (2017) The effects of hospice-shared care for gastric cancer patients. PLoS One 12(2), e0171365. https://doi.org/10.1371/journal.pone.0171365CrossRefGoogle ScholarPubMed
Kao, C-Y, Wang, H-M, Tang, S-C, et al. (2014) Predictive factors for do-not-resuscitate designation among terminally ill cancer patients receiving care from a palliative care consultation service. Journal of Pain and Symptom Management 47(2), 271–282. https://doi.org/10.1016/j.jpainsymman.2013.03.020Google ScholarPubMed
Kavalieratos, D, Corbelli, J, Zhang, D, et al. (2016) Association between palliative care and patient and caregiver outcomes. JAMA 316(20), 2104. https://doi.org/10.1001/jama.2016.16840CrossRefGoogle ScholarPubMed
Kelley, AS and Morrison, RS (2015) Palliative care for the seriously ill. New England Journal of Medicine 373(8), 747–755. https://doi.org/10.1056/NEJMra1404684CrossRefGoogle ScholarPubMed
Kerr, CW, Tangeman, JC, Rudra, CB, et al. (2014) Clinical impact of a home-based palliative care program: A hospice-private payer partnership. Journal of Pain and Symptom Management 48(5), 883–892.e1. https://doi.org/10.1016/j.jpainsymman.2014.02.003Google ScholarPubMed
Lund, S, Richardson, A and May, C (2015) Barriers to advance care planning at the end of life: An explanatory systematic review of implementation studies. PLoS One 10(2), e0116629. https://doi.org/10.1371/journal.pone.0116629Google ScholarPubMed
Lustbader, D, Pekmezaris, R, Frankenthaler, M, et al. (2011) Palliative medicine consultation impacts DNR designation and length of stay for terminal medical MICU patients. Palliative and Supportive Care 9(4), 401–406. https://doi.org/10.1017/S1478951511000423Google ScholarPubMed
McDonald, JC, du Manoir, JM, Kevork, N, et al. (2017) Advance directives in patients with advanced cancer receiving active treatment: Attitudes, prevalence, and barriers. Supportive Care in Cancer 25(2), 523–531. https://doi.org/10.1007/s00520-016-3433-6CrossRefGoogle Scholar
Nakano, K, Yoshida, T, Furutama, J, et al. (2012) Quality of end-of-life care for patients with metastatic non-small-cell lung cancer in general wards and palliative care units in Japan. Supportive Care in Cancer 20(4), 883–888. https://doi.org/10.1007/s00520-011-1374-7CrossRefGoogle ScholarPubMed
O'Mahony, S, McHenry, J, Blank, AE, et al. (2010) Preliminary report of the integration of a palliative care team into an intensive care unit. Palliative Medicine 24(2), 154–165. https://doi.org/10.1177/0269216309346540CrossRefGoogle ScholarPubMed
Omondi, S, Weru, J, Shaikh, AJ, et al. (2017) Factors that influence advance directives completion amongst terminally ill patients at a tertiary hospital in Kenya. BMC Palliative Care 16(1), 9. https://doi.org/10.1186/s12904-017-0186-zCrossRefGoogle Scholar
Parker-Oliver, D, Porock, D, Zweig, S, et al. (2003) Hospice and nonhospice nursing home residents. Journal of Palliative Medicine 6(1), 69–75. https://doi.org/10.1089/10966210360510136CrossRefGoogle ScholarPubMed
Patel, MI, Bhattacharya, J, Asch, SM, et al. (2016) Acceptance of advance directives and palliative care referral for veterans with advanced cancer: A retrospective analysis. American Journal of Hospice and Palliative Care 33(8), 742–747. https://doi.org/10.1177/1049909115595216CrossRefGoogle ScholarPubMed
Rabow, MW, Dibble, SL, Pantilat, SZ, et al. (2004) The comprehensive care team. Archives of Internal Medicine 164(1), 83. https://doi.org/10.1001/archinte.164.1.83CrossRefGoogle ScholarPubMed
Radwany, SM, Hazelett, SE, Allen, KR, et al. (2014) Results of the promoting effective advance care planning for elders (PEACE) randomized pilot study. Population Health Management 17(2), 106–111. https://doi.org/10.1089/pop.2013.0017CrossRefGoogle ScholarPubMed
Rand, KL, Banno, DA, Shea, AM, et al. (2016) Life and treatment goals of patients with advanced, incurable cancer. Supportive Care in Cancer 24(7), 2953–2962. https://doi.org/10.1007/s00520-016-3113-6Google ScholarPubMed
Raskin, W, Harle, I, Hopman, WM, et al. (2016) Prognosis, treatment benefit and goals of care: What do oncologists discuss with patients who have incurable cancer? Clinical Oncology 28(3), 209–214. https://doi.org/10.1016/j.clon.2015.11.011CrossRefGoogle ScholarPubMed
Reinhardt, JP, Downes, D, Cimarolli, V, et al. (2017) End-of-life conversations and hospice placement: Association with less aggressive care desired in the nursing home. Journal of Social Work in End-of-Life & Palliative Care 13(1), 61–81. https://doi.org/10.1080/15524256.2017.1282919CrossRefGoogle ScholarPubMed
Sacco, J, Deravin Carr, DR and Viola, D (2013) The effects of the Palliative Medicine Consultation on the DNR status of African Americans in a safety-net hospital. American Journal of Hospice and Palliative Care 30(4), 363–369. https://doi.org/10.1177/1049909112450941CrossRefGoogle Scholar
Sato, K, Miyashita, M, Morita, T, et al. (2008) Quality of end-of-life treatment for cancer patients in general wards and the palliative care unit at a regional cancer center in Japan: A retrospective chart review. Supportive Care in Cancer 16(2), 113–122. https://doi.org/10.1007/s00520-007-0332-xCrossRefGoogle Scholar
Silveira, MJ, Kim, SYH and Langa, KM (2010) Advance directives and outcomes of surrogate decision making before death. New England Journal of Medicine 362(13), 1211–1218. https://doi.org/10.1056/NEJMsa0907901Google ScholarPubMed
Soylu, C, Babacan, T, Sever, AR, et al. (2016) Patients’ understanding of treatment goals and disease course and their relationship with optimism, hope, and quality of life: A preliminary study among advanced breast cancer outpatients before receiving palliative treatment. Supportive Care in Cancer 24(8), 3481–3488. https://doi.org/10.1007/s00520-016-3182-6CrossRefGoogle ScholarPubMed
Stein, GL and Fineberg, IC (2013) Advance care planning in the USA and UK: A comparative analysis of policy, implementation and the social work role. British Journal of Social Work 43(2), 233–248. https://doi.org/10.1093/bjsw/bct013Google Scholar
Sterne, JA, Hernán, MA, Reeves, BC, et al. (2016) ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions. BMJ 355, i4919.CrossRefGoogle ScholarPubMed
Takezako, Y, Ishikawa, S and Kajii, E (2013) Advance directives in Japanese nursing homes. Journal of Pain and Symptom Management 45(1), 63–70.e7. https://doi.org/10.1016/j.jpainsymman.2011.12.287CrossRefGoogle ScholarPubMed
Tan, A, Seah, A, Chua, G, et al. (2014) Impact of a palliative care initiative on end-of-life care in the general wards: A before-and-after study. Palliative Medicine 28(1), 34–41. https://doi.org/10.1177/0269216313484379CrossRefGoogle ScholarPubMed
Temel, JS, Greer, JA, Muzikansky, A, et al. (2010) Early palliative care for patients with metastatic non-small-cell lung cancer. New England Journal of Medicine 363(8), 733–742. https://doi.org/10.1056/NEJMoa1000678CrossRefGoogle ScholarPubMed
Temel, JS, Greer, JA, El-Jawahri, A, et al. (2017) Effects of early integrated palliative care in patients with lung and GI cancer: A randomized clinical trial. Journal of Clinical Oncology 35(8), 834–841. https://doi.org/10.1200/JCO.2016.70.5046CrossRefGoogle ScholarPubMed
Thomas, TH, Jackson, VA, Carlson, H, et al. (2019) Communication differences between oncologists and palliative care clinicians: A qualitative analysis of early, integrated palliative care in patients with advanced cancer. Journal of Palliative Medicine 22(1), 41–49. https://doi.org/10.1089/jpm.2018.0092CrossRefGoogle ScholarPubMed
White, B, Tilse, C, Wilson, J, et al. (2014) Prevalence and predictors of advance directives in Australia. Internal Medicine Journal 44(10), 975–980. https://doi.org/10.1111/imj.12549CrossRefGoogle ScholarPubMed
Yadav, KN, Gabler, NB, Cooney, E, et al. (2017) Approximately one in three us adults completes any type of advance directive for end-of-life care. Health Affairs 36(7), 1244–1251. https://doi.org/10.1377/hlthaff.2017.0175CrossRefGoogle ScholarPubMed
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