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Biopsychosocial distress and clinical outcome in metastatic renal cell carcinoma

Published online by Cambridge University Press:  18 June 2018

Cristiane Decat Bergerot Open the ORCID record for Cristiane Decat Bergerot [Opens in a new window] ,
Karen Lynn Clark ,
Kimlin Tam Ashing ,
Paulo Gustavo Bergerot ,
Richard Obenchain ,
Nazli Dizman ,
JoAnn Hsu ,
Errol Philip ,
Matthew Loscalzo  and
Sumanta Kumar Pal
Cristiane Decat Bergerot
Affiliation:
Department of Medical Oncology & Experimental Therapeutics, City of Hope, Duarte, CA
Karen Lynn Clark
Affiliation:
Department of Medical Oncology & Experimental Therapeutics, City of Hope, Duarte, CA
Kimlin Tam Ashing
Affiliation:
Department of Population Sciences, City of Hope, Duarte, CA
Paulo Gustavo Bergerot
Affiliation:
Department of Medical Oncology & Experimental Therapeutics, City of Hope, Duarte, CA
Richard Obenchain
Affiliation:
Department of Supportive Care Medicine, City of Hope, Duarte, CA
Nazli Dizman
Affiliation:
Department of Medical Oncology & Experimental Therapeutics, City of Hope, Duarte, CA
JoAnn Hsu
Affiliation:
Department of Medical Oncology & Experimental Therapeutics, City of Hope, Duarte, CA
Errol Philip
Affiliation:
The Notre Dame Laboratory for Psycho-Oncology Research, University of Notre Dame, Notre Dame, IL
Matthew Loscalzo
Affiliation:
Department of Supportive Care Medicine, City of Hope, Duarte, CA
Sumanta Kumar Pal*
Affiliation:
Department of Medical Oncology & Experimental Therapeutics, City of Hope, Duarte, CA
*
Author for correspondence: Sumanta K. Pal, M.D., Department of Medical Oncology & Experimental Therapeutics, 1500 East Duarte Road, Duarte, CA 91010. E-mail: spal@coh.org
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Abstract

Objective

Limited research exists examining the biopsychosocial experience of patients diagnosed with metastatic renal cell carcinoma (mRCC), a disease commonly associated with a poor prognosis. The purpose of this study was to describe rates and types of distress in mRCC patients and explore the relationship between distress and overall survival.

Method

A cohort of 102 patients with mRCC treated at a single institution was assessed by a touch screen–based instrument comprising 22 core items spanning physical, practical, functional, and emotional domains. Association between biopsychosocial distress and clinicopathologic criteria was interrogated. Overall survival was compared between patients with low distress versus high distress.

Result

High rates of distress (20.7%) were found among patients newly diagnosed with mRCC. Among those domains contributing to distress, pain, fatigue, and financial comorbidity were the most commonly reported by patients with mRCC. A trend toward poorer overall survival in those patients with high distress versus low distress was observed among mRCC patients.

Significance of results

Based on data from a relatively large sample of patients, this study provides the first specific insights into the potential impact of biopsychosocial distress and outcomes among patients with mRCC.

Keywords

Kidney cancermetastatic diseasedistress screeningoverall survivalbiopsychosocial distress
Type
Original Article
Information
Palliative & Supportive Care , Volume 17 , Issue 3 , June 2019 , pp. 353 - 355
Copyright
Copyright © Cambridge University Press 2018 

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