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Effects of a multidisciplinary quality of life intervention on sleep quality in patients with advanced cancer receiving radiation therapy

Published online by Cambridge University Press:  26 September 2019

Melanie T. Gentry Open the ORCID record for Melanie T. Gentry [Opens in a new window] ,
Pamela J. Atherton ,
Maria Lapid ,
Preetha Sharone Rosen ,
Simon Kung ,
Jarrett Richardson ,
Shehzad K. Niazi ,
William V. Bobo ,
Matthew M. Clark  and
Teresa A. Rummans
Melanie T. Gentry*
Affiliation:
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN
Pamela J. Atherton
Affiliation:
Cancer Center Statistics Section, Division of Biomedical Statistics and Informatics, Department of Health Sciences, Mayo Clinic, Rochester, MN
Maria Lapid
Affiliation:
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN
Preetha Sharone Rosen
Affiliation:
Peace Health St John Medical Center, Longview, Washington, WA
Simon Kung
Affiliation:
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN
Jarrett Richardson
Affiliation:
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN
Shehzad K. Niazi
Affiliation:
Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL
William V. Bobo
Affiliation:
Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL
Matthew M. Clark
Affiliation:
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN
Teresa A. Rummans
Affiliation:
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL
*
Author for correspondence: Melanie T. Gentry M.D., Department of Psychiatry and Psychology, Mayo Clinic Rochester, 200 1st Street SW, Rochester, MN55905. E-mail: gentry.melanie@mayo.edu
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Abstract

Objectives

Sleep disturbances are prevalent in cancer patients, especially those with advanced disease. There are few published intervention studies that address sleep issues in advanced cancer patients during the course of treatment. This study assesses the impact of a multidisciplinary quality of life (QOL) intervention on subjective sleep difficulties in patients with advanced cancer.

Method

This randomized trial investigated the comparative effects of a multidisciplinary QOL intervention (n = 54) vs. standard care (n = 63) on sleep quality in patients with advanced cancer receiving radiation therapy as a secondary endpoint. The intervention group attended six intervention sessions, while the standard care group received informational material only. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS), administered at baseline and weeks 4 (post-intervention), 27, and 52.

Results

The intervention group had a statistically significant improvement in the PSQI total score and two components of sleep quality and daytime dysfunction than the control group at week 4. At week 27, although both groups showed improvements in sleep measures from baseline, there were no statistically significant differences between groups in any of the PSQI total and component scores, or ESS. At week 52, the intervention group used less sleep medication than control patients compared to baseline (p = 0.04) and had a lower ESS score (7.6 vs. 9.3, p = 0.03).

Significance of results

A multidisciplinary intervention to improve QOL can also improve sleep quality of advanced cancer patients undergoing radiation therapy. Those patients who completed the intervention also reported the use of less sleep medication.

Keywords

PalliativeSedative and hypnoticsSleep dysfunctionWell-being
Type
Original Article
Information
Palliative & Supportive Care , Volume 18 , Issue 3 , June 2020 , pp. 307 - 313
Copyright
Copyright © Cambridge University Press 2019

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Footnotes

This article has been corrected since its original publication. See doi:10.1017/S147895151900083X.

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