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The promise of clinical interventions for hepatocellular carcinoma from the west to mainland China

Published online by Cambridge University Press:  11 February 2013

Mei Bai ,
Nancy R. Reynolds  and
Ruth McCorkle
Mei Bai*
Affiliation:
School of Nursing, Yale University, New Haven, Connecticut
Nancy R. Reynolds
Affiliation:
School of Nursing, Yale University, New Haven, Connecticut
Ruth McCorkle
Affiliation:
School of Nursing, Yale University, New Haven, Connecticut
*
Address correspondence and reprint requests to: Mei Bai, Yale University School of Nursing, 100 Church Street South, PO Box 9740, New Haven, CT 06536-0740. E-mail: mei.bai@yale.edu
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Abstract

Objective:

Hepatocellular carcinoma (HCC) presents a major health problem with its steadily increasing incidence in Western countries, and persistent high fatality rates worldwide. The well-recognized complexity and toxicity of its treatment as well as inadequate care and limited resources in mainland China exacerbate the difficulty of maintaining quality of remaining life of patients living with this illness. The goal of this comprehensive literature review was to identify promising clinical interventions for improving quality of life (QOL) of people with advanced HCC in mainland China.

Method:

A comprehensive literature review was performed in China Academic Journals (CAJ), Cochrane, and PubMed databases. The review was confined to studies of randomized controlled trials (RCT) for adults, in Chinese and English, from 1980 to 2012.

Results:

A total of 676 studies in Chinese and 391 studies in English were identified. Eighteen RCTs were selected for the final review, among which three were conducted in mainland China.

Significance of results:

Nurse-led home-based comprehensive interventions using a collaborative care approach addressing multiple dimensions of QOL show promise for enhancing clinical outcomes for people with advanced HCC in mainland China. Education and psychosocial support combined with symptom management early in the illness trajectory and ongoing close attention to physical symptoms, emotional distress, as well as spiritual well-being are crucial for maintaining QOL of people with advanced HCC. Telephone monitoring appears to be a feasible way in rural as well as urban areas. Families are advised to be part of overall interventions. It is warranted that promising interventions aiming at improving QOL for advanced cancer patients reported in Western literature be further tested in mainland China.

Keywords

HCCRCTQOLAdvanced cancerMainland China
Type
Review Articles
Information
Palliative & Supportive Care , Volume 11 , Issue 6 , December 2013 , pp. 503 - 522
Copyright
Copyright © Cambridge University Press 2013 

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References

REFERENCES

Ahmed, N., Ahmedzai, S., Vora, V., et al. (2004). Supportive care for patients with gastrointestinal cancer (Review). Cochrane Database of Systematic Reviews, 3, CD003445.Google Scholar
Allen, J. & Venook, A. (2004). Hepatocellular carcinoma: Epidemic and treatment. Current Oncology Reports, 6, 177–183.CrossRefGoogle ScholarPubMed
*Ando, M., Morita, T., Akechi, T., et al. (2010). Efficacy of short-term life-review interviews on the spiritual well-being of terminally ill cancer patients. Journal of Pain and Symptom Management, 39, 993–1002.Google Scholar
Baker, F., Denniston, M., Zabora, J., et al. (2002). A POMS short form for cancer patients: psychometric and structural evaluation. Psycho-oncology, 11, 273–281.Google Scholar
*Bakitas, M., Lyons, K.D., Hegel, M.T. et al. (2009). Effects of a palliative care intervention on clinical outcomes in patients with advanced cancer: The project ENABLE II randomized controlled trial. Journal of the American Medical Association, 302, 741–749.Google Scholar
Boutron, I., Moher, D., Altman, D.G., et al. (2008). Extending the CONSORT statement to randomized trials of nonpharmacologic treatment: explanation and elaboration. Annals of Internal Medicine, 148, 295–309.CrossRefGoogle Scholar
*Breitbart, W., Poppito, S., Rosenfeld, B., et al. (2012). Pilot randomized controlled trial of individual meaning-centered psychotherapy for patients with advanced cancer. Journal of Clinical Oncology, 30, 1304–1309.Google Scholar
*Breitbart, W., Rosenfeld, B., Gibson, C. et al. (2010). Meaning-centered group psychotherapy for patients with advanced cancer: a pilot randomized controlled trial. Psycho-oncology, 19, 21–28.Google Scholar
Bruera, E., Kuehn, N., Miller, M., et al. (1991). The Edmonton Symptom Assessment System (ESAS): a simple method for the assessment of palliative care patients. Journal of Palliative Care, 7, 6–9.Google Scholar
Bruix, J. & Llovet, J. (2002). Prognostic prediction and treatment strategy in hepatocellular carcinoma. Hepatology, 35, 519–524.Google Scholar
Bruix, J., Sala, M. & Llovet, J.M. (2004). Chemoembolization for hepatocellular carcinoma. Gastroenterology, 127, S179–188.Google Scholar
Bruix, J. & Sherman, M. (2005). Management of hepatocellular carcinoma. Hepatology, 42, 1208–1236.CrossRefGoogle ScholarPubMed
Bruix, J. & Sherman, M. (2011). Management of hepatocellular carcinoma: An update. Hepatology, 53, 1020–1022.CrossRefGoogle ScholarPubMed
Cella, D., Hahn, E.A. & Dineen, K. (2002). Meaningful change in cancer-specific quality of life scores: differences between improvement and worsening. Quality of Life Research, 11, 207–221.CrossRefGoogle ScholarPubMed
*Chochinov, H.M., Kristjanson, L.J., Breitbart, W., et al. (2011). Effect of dignity therapy on distress and end–of-life experience in terminally ill patients: a randomised controlled trial. Lancet Oncology, 12, 753–762.CrossRefGoogle ScholarPubMed
Corbin, J.M. & Strauss, A. (1991). A nursing model for chronic illness management based upon the trajectory framework. Scholarly Inquiry for Nursing Practice, 5, 155–174.Google Scholar
Cunningham, A.J. (2002). Group psychological therapy: An integral part of care for cancer patients. Integrative Cancer Therapies, 1, 67–75.CrossRefGoogle ScholarPubMed
Dong, G.L., Shen, M.Y., Shen, J., et al. (2009). Investigation and analysis on therapeutic compliance and its influential factors in hepatocellular carcinoma patients with transarterial chemoembolization [in Chinese]. Nursing Journal of Chinese PLA, 26, 30–32.Google Scholar
Eltawil, K.M., Berry, R., Abdolell, M., et al. (2012). Quality of life and survival analysis of patients undergoing transarterial chemoembolization for primary hepatic malignancies: A prospective cohort study. HPB (Oxford), 14, 341–350.Google Scholar
Fan, S., Elser, C. & Ho, M. (2010). Health-related quality of life in patients with hepatocellular carcinoma: A systematic review. Clinical Gastroenterology and Hepatology, 8, 559–564.CrossRefGoogle ScholarPubMed
Ferlay, J., Shin, H., Bray, F., et al. (2010). Estimates of worldwide burden of cancer in 2008: Globocan 2008. International Journal of Cancer, 127, 2893–2917.CrossRefGoogle ScholarPubMed
Fielding, R. (2010). Hepatobiliary cancer. In Psycho-oncology. Holland, J.C., Breitbart, P.B., Jacobsen, M.S., et al. (eds.), pp. 146–151. New York: Oxford University Press.Google Scholar
Forner, A., Llovet, J.M. & Bruix, J. (2012). Chemoembolization for intermediate HCC: Is there proof of survival benefit? Journal of Hepatology, 56, 984–986.Google Scholar
Forner, A., Reig, M., de Lope, C., et al. (2010). Current strategy for staging and treatment: The BCLC update and future prospects. Seminars in Liver Disease, 30, 61–74.Google Scholar
Fu, X.X. & Zhang, Y.C. (2007). Hospice in the perspective of anthropology. Journal of Social Sciences, 9, 115–123.Google Scholar
*Guo, Y.M. (2005). Effects of emotional intervention and Chinese medicated diet in improving the quality of life in patients with liver cancer after chemotherapy [in Chinese]. Chinese Journal of Clinical Rehabilitation, 9, 30–31.Google Scholar
Hall, S., Kolliakou, A., Petkova, H., et al. (2011). Interventions for improving palliative care for older people living in nursing care homes (Review). Cochrane Database of Systematic Reviews, 16, CD007132.Google Scholar
*Hudson, P.L., Aranda, S. & Hayman–White, K. (2005). A psycho-educational intervention for family caregivers of patients receiving palliative care: A randomized controlled trial. Journal of Pain and Symptom Management, 30, 329–341.Google Scholar
*Jordhøy, M.S., Fayers, P., Loge, J.H., et al. (2001). Quality of life in palliative cancer care. Journal of Clinical Oncology, 19, 3884–3894.Google Scholar
Kirchhoff, K. T. (2004). State of the science of translational research: from demonstration projects to intervention testing. Worldviews on Evidence-Based Nursing, 1, S6–12.Google Scholar
*Lee, A.M., Ho, J.W. & Chan, C.L. (2010). Efficacy of psychosocial intervention in improving quality of life and psychological well-being of Chinese patients with colorectal cancer: A randomised controlled trial, Hong Kong Medical Journal, 16, 20–24.Google ScholarPubMed
*Li, Y.Q., Zhang, M.X., Fu, G.X., et al. (2006). Effect of hospice care on the quality of life and psychological state of aged dying inpatients (in Chinese). Journal of Central South University (Med Sci), 31, 538–542.Google Scholar
*Linn, M.W., Linn, B.S. & Harris, R. (1982). Effects of counseling for late stage cancer patients. Cancer, 49, 1049–1055.Google Scholar
Llovet, J.M. & Bruix, J. (2003). Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Hepatology, 37, 429–442.Google Scholar
Llovet, J.M., Di-Bisceglie, A.M., Bruix, J., et al. (2008a). Design and endpoints of clinical trials in hepatocellular carcinoma. Journal of the National Cancer Institute, 100, 698–711.CrossRefGoogle ScholarPubMed
Llovet, J.M., Real, M. & Montaña, X. (2002). Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: A randomised controlled trial. Lancet, 359, 1734–1739.Google Scholar
Llovet, J.M., Ricci, S., Mazzaferro, V., et al. (2008b). Sorafenib in advanced hepatocellular carcinoma. The New England Journal of Medicine, 359, 378–390.Google Scholar
Locke, D.E.C., Decker, P.A., Sloan, J.A. et al. (2007). Validation of single-item linear analog scale assessment of quality of life in neuro-oncology patients. Journal of Pain and Symptom Management, 34, 628–638.CrossRefGoogle ScholarPubMed
Lopez, P.M., Villanueva, A. & Llovet, J.M. (2006). Systematic review: Evidence-based management of hepatocellular carcinoma—An updated analysis of randomized controlled trials. Alimentary Pharmacology &Therapeutics, 23, 1535–1547.Google Scholar
Lyons, K.D., Bakitas, M., Hegel, M.T., et al. (2009). Reliability and validity of the Functional Assessment of Chronic Illness Therapy-Palliative care (FACIT-Pal) scale. Journal of Pain and Symptom Management, 37, 23–32.CrossRefGoogle ScholarPubMed
*McCorkle, R., Benoliel, J.Q., Donaldson, G., et al. (1989). A randomized clinical trial of home nursing care for lung cancer patients. Cancer, 64, 1375–1382.Google Scholar
*McCorkle, R., Dowd, M., Ercolano, E., et al. (2009). Effects of a nursing intervention on quality of life outcomes in pust-surgical women with gynecological cancers. Psycho-oncology, 18, 62–70.Google Scholar
McCorkle, R., Hughes, L. & Robinson, L. (1998). Nursing interventions for newly diagnosed older cancer patients facing terminal illness. Journal of Palliative Care, 14, 39–45.Google Scholar
McCorkle, R. & Pasacreta, V. (2001). Enhancing caregiver outcomes in palliative care. Cancer Control, 8, 36–45.Google Scholar
McCorkle, R., Strumpf, N.E., Nuamah, I.F., et al. (2000). A specialized home care intervention improves survival among older post-surgical cancer patients. Journal of the American Geriatrics Society, 48, 1707–1713.Google ScholarPubMed
McCorkle, R. & Young, K. (1978). Development of a symptom distress scale. Cancer Nursing, 1, 373–378.Google Scholar
McGlynn, K.A. & London, W.T. (2005). Epidemiology and natural history of hepatocellular carcinoma. Best Practice & Research. Clinical Gastroenterology, 19, 3–23.CrossRefGoogle ScholarPubMed
McGlynn, K.A., Tsao, L., Hsing, A.W., et al. (2001). International trends and patterns of primary liver cancer. International Journal of Cancer, 94, 290–296.Google Scholar
Milone-Nuzzo, P. & McCorkle, R. (2001). Home care. In Textbook of Palliative Nursing. Ferrell, B. R. & Coyle, N. (eds.), pp. 543–555. New York: Oxford University Press.Google Scholar
*Moore, S., Coner, J., Haviland, J., et al. (2002). Nurse led follow up and conventional medical follow up in management of patients with lung cancer: randomized trial. British Medical Journal, 325, 1145–1151.Google Scholar
Oliveri, R.S., Wetterslev, J. & Gluud, C. (2011). Transarterial (chemo) embolisation for unresectable hepatocellular carcinoma (Review). Cochrane Database of Systematic Reviews, 16, CD004787.Google Scholar
Okun, A., Stein, R.E., Bauman, L.J., et al. (1996). Content validity of the Psychiatric Symptom Index, CES-Depression Scale, and State-Trait Anxiety Inventory from the perspective of DSM-IV. Psychological Reports, 79, 1059–1069.Google Scholar
Parkin, D., Bray, F., Ferly, J., et al. (2005). Global cancer statistics, 2002. CA: A Cancer Journal for Clinicians, 55, 74–108.Google Scholar
Peterman, A.H., Fitchett, G., Brady, M.J., et al. (2002). Measuring spiritual well-being in people with cancer: The Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being Scale (FACIT-Sp). Annals of Behavioral Medicine, 24, 49–58.Google Scholar
Poon, R.T., Fan, S.T., Tsang, F.H., et al. (2002). Locoregional therapies for hepatocellular carcinoma: a critical review from the surgeon's perspective. Annals of Surgery, 235, 466–486.Google Scholar
Rampone, B., Schiavone, B., Martino, A., et al. (2009). Current management strategy of hepatocellular carcinoma. World Journal of Gastroenterology, 15, 3210–3216.CrossRefGoogle ScholarPubMed
Ramsey, D.E. & Geschwind, J.F. (2002). Chemoembolization of hepatocellular carcinoma—what to tell the skeptics: Review and meta-analysis. Techniques in Vascular and Interventional Radiology, 5, 122–126.Google Scholar
Raoul, J.L., Sangro, B., Forner, A., et al. (2011). Evolving strategies for the management of intermediate-stage hepatocellular carcinoma: Available evidence and expert opinion on the use of transarterial chemoembolization. Cancer Treatment Reviews, 37, 212–220.Google Scholar
Rehse, B. & Pukrop, R. (2003). Effects of psychosocial interventions on quality of life in adult cancer patients: meta analysis of 37 published controlled outcome studies. Patient Education and Counseling, 50, 179–186.CrossRefGoogle ScholarPubMed
Robinson, L., Nuamah, I.F., Cooley, M.E., et al. (1997). A test of the fit between the Corbin and Strauss trajectory model and care provided to older patients after cancer surgery. Holistic Nursing Practice, 12, 36–47.Google Scholar
*Rummans, T.A., Clark, M.M., Sloan, J.A. et al. (2006). Impacting quality of life for patients with advanced cancer with a structured multidisciplinary intervention: A randomized controlled trial. Journal of Clinical Oncology, 24, 635–642.Google Scholar
Schulz, K.F., Altman, D.G. & Moher, D. (2010). CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomized Trials. Annals of Internal Medicine, 152, 726–732.Google Scholar
Steel, J., Baum, A. & Carr, B. (2004). Quality of life in patients diagnosed with primary hepatocellular carcinoma: Hepatic arterial infusion of Cisplatin versus 90-Yttrium microspheres (Therasphere). Psycho-oncology, 13 73–79.CrossRefGoogle ScholarPubMed
Steel, J.L., Eton, D.T., Cella, D., et al. (2006). Clinically meaningful changes in health-related quality of life in patients diagnosed with hepatobiliary carcinoma. Annals of Oncology, 17, 304–312.Google Scholar
*Steel, J., Geller, D.A., Tsung, A., et al. (2011). Randomized controlled trial of a collaborative care intervention to manage cancer-related symptoms: lessons learned. Clinical Trials, 8, 298–310.Google Scholar
*Steel, J.L., Nadeau, K., Olek, M., et al. (2007). Preliminary results of an individually tailored psychosocial intervention for patients with advanced hepatobiliary carcinoma. Journal of Psychosocial Oncology, 25, 19–42.Google Scholar
Stehlin, J.S. & Beach, K.H. (1966). Psychological aspects of cancer therapy. Journal of American Medical Association, 197, 100–104.Google Scholar
Stetler, C.B., Morsi, D., Rucki, S., et al. (1998). Utilization-focused integrative reviews in a nursing service. Applied Nursing Research, 11, 195–206.Google Scholar
Sun, V., Ferrell, B., Juarez, G., et al. (2008). Symptom concerns and quality of life in hepatobiliary cancers. Oncology Nursing Forum, 35, E45–E52.Google Scholar
Tedeschi, R.G. & Calhoun, L.G. (1996). The posttraumatic growth inventory: Measuring the positive legacy of trauma. Journal of Traumatic Stress, 9, 455–471.Google Scholar
Teo, E.K.&, Fock, K.M. (2001). Hepatocellular carcinoma: an Asian perspective. Digestive Diseases, 19, 263–268.Google Scholar
Toro, A., Pulvirenti, E., Palermo, F., et al. (2012). Health-related quality of life in patients with hepatocellular carcinoma after hepatic resection, transcatheter arterial chemoembolization, radiofrequency ablation or no treatment. Surgical Oncology, 21, e23–30.Google Scholar
Vogl, T.J., Naguib, N.N., Nour-Eldin, N.E., et al. (2009). Review on transarterial chemoembolization in hepatocellular carcinoma: palliative, combined, neoadjuvant, bridging, and symptomatic indications. European Journal of Radiology, 72, 505–516.CrossRefGoogle ScholarPubMed
*Wang, J.F., Zhou, J.H. & Ma, X.Q. (2010). Community nursing intervention mode for tumor patients [in Chinese]. Nursing Journal of Chinese PLA, 27, 881–884, 906.Google Scholar
Wu, M.C., Tang, Z.Y., Sun, Y., et al. (2011). Guideline for standardized treatment of primary liver cancer [in Chinese]. Chinese Clinical Oncology, 16, 929–946.Google Scholar
Wu, P., Dugoua, J.J., Eyawo, O., et al. (2009). Traditional Chinese medicines in the treatment of hepatocellular cancers: a systematic review and meta-analysis. Journal of Experimental & Clinical Cancer Research, 28, 112–124.Google Scholar
Yan, H. & Sellick, K. (2004). Symptoms, psychological distress, social support, and quality of life of Chinese patients newly diagnosed with gastrointestinal cancer. Cancer Nursing, 27, 389–399.Google Scholar
Yuen, M.F., Hou, J.L., Chutaputti, A., et al. (2009). Hepatocellular carcinoma in the Asia pacific region. Journal of Gastroenterology and Hepatology, 24, 346–353.CrossRefGoogle ScholarPubMed
Zimmermann, C., Riechelmann, R., Krzyzanowska, M., et al. (2008). Effectiveness of specialized palliative care: a systematic review. Journal of the American Medical Association, 299, 1698–1709.CrossRefGoogle ScholarPubMed