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Acetate and succinate production in amoebae, helminths, diplomonads, trichomonads and trypanosomatids: common and diverse metabolic strategies used by parasitic lower eukaryotes

Published online by Cambridge University Press:  23 December 2009

F. BRINGAUD ,
C. EBIKEME  and
M. BOSHART
F. BRINGAUD*
Affiliation:
Résonance Magnétique des Systèmes Biologiques, UMR-5536 CNRS, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France
C. EBIKEME
Affiliation:
Résonance Magnétique des Systèmes Biologiques, UMR-5536 CNRS, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France
M. BOSHART
Affiliation:
Biozentrum, Genetik, Ludwig-Maximilians-Universität München, Grosshadernerstr. 2-4, D-82152 Martinsried, Germany
*
*Corresponding author: Tel: (33) 5 57 57 46 32. Fax: (33) 5 57 57 45 56. E-mail: bringaud@rmsb.u-bordeaux2.fr
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Summary

Parasites that often grow anaerobically in their hosts have adopted a fermentative strategy relying on the production of partially oxidized end products, including lactate, glycerol, ethanol, succinate and acetate. This review focuses on recent progress in understanding acetate production in protist parasites, such as amoebae, diplomonads, trichomonads, trypanosomatids and in the metazoan parasites helminths, as well as the succinate production pathway(s) present in some of them. We also describe the unconventional organisation of the tricarboxylic acid cycle associated with the fermentative strategy adopted by the procyclic trypanosomes, which may resemble the probable structure of the primordial TCA cycle in prokaryotes.

Keywords

acetate and succinate excretionacetate:succinate CoA-transferaseEntamoeba histolyticaFasciola hepaticafumarate reductaseGiardia lambliareductive TCA cycleTrichomonas vaginalisTrypanosoma brucei
Type
Research Article
Information
Parasitology , Volume 137 , Special Issue 9: Insights into the metabolomes of parasites , August 2010 , pp. 1315 - 1331
Copyright
Copyright © Cambridge University Press 2009

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