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Acquired immunity to Trichuris muris in the albino laboratory mouse

Published online by Cambridge University Press:  06 April 2009

D. Wakelin
D. Wakelin
Affiliation:
Department of Zoology, Bedford College, London, N. W. 1
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Extract

After infection with the nematode Trichuris muris 70–75% of mice of the Schofield strain developed an immunity to the parasite and eliminated the worms between the 16th and 19th days after infection. In these mice the acquired immunity persisted for at least 3 months and prevented the establishment of subsequent infections.

In 25–30% of the mice immunity was not produced and infections developed into mature worms. These non-resistant mice remained susceptible to further infection.

The development and action of the immune response were suppressed completely by the administration of cortisone acetate.

Type
Research Article
Information
Parasitology , Volume 57 , Issue 3 , August 1967 , pp. 515 - 524
Copyright
Copyright © Cambridge University Press 1967

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References

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