Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-15T12:35:00.469Z Has data issue: false hasContentIssue false
  • English
  • Français

The chemotherapy of Eperythrozoon coccoides (Schilling, 1928)

Published online by Cambridge University Press:  06 April 2009

June P. Thurston
June P. Thurston
Affiliation:
National Institute for Medical Research, The Ridgeway, London, N.W. 7*
Get access Rights & Permissions [Opens in a new window]

Extract

In tests for chemotherapeutic activity, mice were infected with Eperythrozoon coccoides, treated with drugs for 2 days, splenectomized, and treated with drugs for a further 2 days. Blood films were examined from the second day after splenectomy, when control mice showed heavy blood infections.

Neoarsphenamine, aureomycin and terramycin were active.

Tryparsamide, Chloromycetin, alloxan and polyoxyethylene ether, D2, were slightly active.

Many drugs, listed in Table 3, were inactive.

Neoarsphenamine cleared E. coccoides from the blood very rapidly. This action was inhibited by dimercaprol (BAL).

E. coccoides closely resembles Haemobartonella muris in its sensitivity to drugs. Both micro-organisms probably have affinities with the Rickettsiae.

Type
Research Article
Information
Parasitology , Volume 43 , Issue 1-2 , May 1953 , pp. 170 - 174
Copyright
Copyright © Cambridge University Press 1953

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Cornforth, J. W., Hart, P. D'A., Rees, R. J. W. & Stock, J. A. (1951). Antituberculous effect of certain surface-active polyoxyethylene ethers in mice. Nature, Lond., 168, 150.CrossRefGoogle ScholarPubMed
Delpy, L. & Rafyi, A. (1938). Sur la morphologie, l'évolution et la différentiation d'Eperythrozoon wenyoni (Adler, 1934). Bull. Acad. vét. Fr. 11, 203.Google Scholar
van den Ende, M., Stuart-Harris, C. H., Fulton, F. & Niven, J. S. (1946). Chemotherapeutic and other studies of typhus. Spec. Rep. Ser. med. Res. Court., Lond., no. 255.Google Scholar
Findlay, G. M. (1950, 1951). Recent Advances in Chemotherapy, vols. 1 and 2, 3rd ed.London: J. and A. Churchill Ltd.Google Scholar
Laskowski, L., Stanton, M. F. & Pinkerton, H. (1951). Chemotherapeutic effectiveness of alloxan in murine Bartonellosis. Proc. Soc. exp. Biol., N.Y., 76, 475.CrossRefGoogle ScholarPubMed
Mayer, M., Borchardt, W. & Kikuth, W. (1927). Die durch Milzexstirpation auslösbare infektiöse Rattenanämie. Arch. Schiffs- u. Tropenhyg. Beihefte. 31, 295.Google Scholar
Mesnil, F. (1929). Eperythrozoon coccoides. Bull. Soc. Pat. exot. 22, 531.Google Scholar
Neitz, W. O. (1937). Eperythrozoönosis in sheep. Onderstepoort J. vet. Sci. 9, 9.Google Scholar
Neitz, W. O. (1940). Eperythrozoönosis in cattle. Onderstepoort J. vet. Sci. 14, 9.Google Scholar
Neitz, W. O., Alexander, R. A. & Du Toit, P. J. (1934). Eperythrozoon ovis (sp. nov.) infection in sheep. Onderstepoort J. vet. Sci. 3, 263.Google Scholar
Schilling, V. (1928). Eperythrozoon coccoides, eine neue durch Splenektomie aktivierbare Dauerinfektion der weissen Maus. Klin. Wschr. p. 1853.CrossRefGoogle Scholar
Schmidt, H. (1942). Aus neueren Forschungen über Antimonpräparate. In Medizin und Chemie, vol. 4, 164. Berlin: Verlag Chemie G.M.B.H.Google Scholar
Splitter, E. J. (1950 a). Eperythrozoon suis, the etiologic agent of ictero-anaemia or an Anaplasmosis-like disease of swine. Amer. J. vet. Res. 11, 324.Google ScholarPubMed
Splitter, E. J. (1950 b). Neoarsphenamine in acute Eperythrozoonosis of swine. Amer. vet. med. Ass. 117, 371.Google ScholarPubMed
Splitter, E. J. (1950 c). Ictero-anaemia of swine. Proc. U.S. Live Stk Sanit. Ass. 55, 279.Google Scholar
Stanton, M. F., Laskowski, L. & Pinkerton, H. (1950). Chemoprophylactic effectiveness of aureomycin and terramycin in murine Bartonellosis. Proc. Soc. exp. Biol., N.Y., 74, 705.CrossRefGoogle ScholarPubMed
Tyzzer, E. E. & Weinman, D. (1939). Haemobartonella n.g. (Bartonella alim pro parte), H. microtin. sp., of the field vole, Microtus pennsylvanicus. Amer. J. Hyg. 30(B), 141.Google Scholar
Uhlenhuth, P. (1931). Experimentelle Grundlagen, Entwicklung und praktische Ergebnisse der modernen Arsen- und Antimontherapie. Klin. Wschr. pp. 1153 and 1201.CrossRefGoogle Scholar
Uhlenhuth, P. & Seiffert, W. (1933). Zur Chemotherapie der Bartonellenanämie mit kaubinierten Arsen-Antimonpräparaten. Z. ImmunForsch. 80, 352.Google Scholar
Vasslliadis, P. (1930–1931). La fonction antiparasitaire de la rate décelée par la splénectomie. Arch. int. Med. exp. 6, 89.Google Scholar
Weinman, D. (1948). In Bergey's Manual of Determinative Bacteriology, 6th ed., 1083. London: Baillière, Tindall and Cox.Google Scholar
Wigand, R. & Peters, D. (1950). Neuere Untersuchungen über Bartonella muris Mayer. Z. Tropenmed. u. Parasit. 2, 206.Google Scholar
Wigand, R. & Peters, D. (1952). Blutparasiten der weissen Maus. I. Studien über Eperythrozoon coccoides Schilling, Dinger. Z. Tropenmed. u. Parasit. 3, 461.Google Scholar