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Different levels of acquired immunity to Schistosoma mansoni in two strains of hamster

Published online by Cambridge University Press:  06 April 2009

M. A. Smith  and
J. A. Clegg
M. A. Smith
Affiliation:
Department of Zoology, Imperial College of Science and Technology, London, SW7 2BB
J. A. Clegg
Affiliation:
National Institute for Medical Research, London, NW7 1AA
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Summary

A primary infection with Schistosoma mansoni, of 5 or more weeks duration, stimulated a high level of resistance to a challenge infection in the WO outbred strain of golden hamster. In sharp contrast, the LGN strain showed no statistically significant immunity to reinfection in most experiments and where detected the level of resistance was only about half that observed in the WO strain. Immunity to reinfection was assayed with the lung recovery method which assesses resistance a few days after challenge and with the conventional perfusion assay which measures immunity 6 weeks after challenge. Wide differences in the immune response to S. mansoni in different strains of the same host species have not been reported previously.

Type
Research Article
Information
Parasitology , Volume 73 , Issue 1 , August 1976 , pp. 47 - 52
Copyright
Copyright © Cambridge University Press 1976

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References

Perez, H., Clegg, J. A. & Smithers, S. R. (1974). Acquired immunity to Schistosoma mansoni in the rat: measurement of immunity by the lung recovery assay. Parasitology 69, 349–59.CrossRefGoogle Scholar
Sher, A., Mackenzie, P. & Smithers, S. R. (1974). Decreased recovery of invading parasites from the lungs as a parameter of acquired immunity to schistosomiasis in the mouse. The Journal of Infectious Diseases 130, 626–33.CrossRefGoogle ScholarPubMed
Smith, M. A., Clegg, J. A., Kusel, J. R. & Webbe, G. (1975). Lung inflammation in immunity to Schistosoma mansoni. Experientia 31, 595–6.CrossRefGoogle ScholarPubMed
Smith, M. A., Clegg, J. A. & Webbe, G. (1976). Cross-immunity to Schistosoma mansoni and S. haematobium in the hamster. Parasitology 73, 53–64.CrossRefGoogle ScholarPubMed
Smithers, S. R. & Terry, R. J. (1965). The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of adult worms. Parasitology 55, 695–700.CrossRefGoogle ScholarPubMed
Wakelin, D. (1975). Genetic control of immune responses to parasites: immunity to Trichuris muris in inbred and random-bred strains of mice. Parasitology 71, 51–60.CrossRefGoogle ScholarPubMed