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Drug-resistance in Plasmodium gallinaceum, and the persistence of paludrine-resistance after mosquito transmission

Published online by Cambridge University Press:  06 April 2009

Ann Bishop  and
Betty Birkett
Ann Bishop
Affiliation:
Molteno Institute, University of Cambridge
Betty Birkett
Affiliation:
Molteno Institute, University of Cambridge
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Extract

1. Attempts, made over a period of more than 6 months, to produce a strain of Plasmodium gallinaceum resistant to mepacrine failed.

2. A strain of P. gallinaceum resistant to daily doses of 0·08 mg./20 g. of pamaquin was obtained after approximately 8 months' treatment with the drug.

3. A strain of P. gallinaceum resistant to the maximum dose of paludrine which the chicks would tolerate (1·0 mg./20 g. twice daily) was obtained after 4½ months' treatment with gradually increasing doses of the drug.

4. The exo-erythrocytic parasites of P. gallinaceum formed in chicks infected with a paludrine-resistant strain are themselves resistant to the drug. It is not, however, considered probable that the development of resistance is due to the action of the drugs upon the exo-erythrocytic parasites, as the technique used was one which reduced their number to a minimum.

5. A strain of P. gallinaceum resistant to paludrine showed a normal sensitivity to mepacrine and pamaquin, but was resistant to 4430, the methyl homologue of paludrine.

6. Chicks carrying a latent infection of the normal strain of P. gallinaceum were immune to infection with the paludrine-resistant strain; and conversely chicks carrying a latent infection of the paludrine-resistant strain were immune to infection with the normal parasite.

7. A paludrine-resistant strain of P. gallinaceum retained its resistance to this drug after five cyclical passages through mosquitoes without intervening drug treatment.

Type
Research Article
Information
Parasitology , Volume 39 , Issue 1-2 , July 1948 , pp. 125 - 137
Copyright
Copyright © Cambridge University Press 1948

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References

REFERENCES

Bishop, A. & Birkett, B.(1947). Nature, Lond., 159, 884.CrossRefGoogle Scholar
Bishop, A., Birkett, B. & Gilchrist, B. M. (1947). Parasitology, 38, 163.CrossRefGoogle Scholar
Coggeshall, L. T., Porter, R. J. & Laird, R. L. (1944). Proc. Soc. exp. Biol., N.Y., 57, 286.CrossRefGoogle Scholar
Coulston, F. & Manwell, R. D. (1940). J. Parasit. 26, Suppl. 27.Google Scholar
Coulston, F. & Manwell, R. D. (1941). Amer. J. Hyg. 34, C, 119.Google Scholar
Curd, F. H. S., Davey, D. G. & Rose, F. L. (1945 a). Ann. trop. Med. Parasit., 39, 139.CrossRefGoogle Scholar
Curd, F. H. S., Davey, D. G. & Rose, F. L. (1945 b). Ann. trop. Med. Parasit. 39, 157.CrossRefGoogle Scholar
Curd, F. H. S., Davey, D. G. & Rose, F. L. (1945 c). Ann. trop. Med. Parasit. 39, 208.CrossRefGoogle Scholar
Davey, D. G. (1946 a). Ann. trop. Med. Parasit. 40, 52.CrossRefGoogle Scholar
Davey, D. G. (1946 b). Ann. trop. Med. Parasit. 40, 453.CrossRefGoogle Scholar
Fairley, N. H. (1946). Trans. R. Soc. trop. Med. Hyg. 40, 105.CrossRefGoogle Scholar
Fulton, J. D. (1942). Ann. trop. Med. Parasit. 36, 75.CrossRefGoogle Scholar
Fulton, J. D. & Yorke, W. (1941). Ann. trop. Med. Parasit. 35, 233.CrossRefGoogle Scholar
Fulton, J. D. & Yorke, W. (1943). Ann. trop. Med. Parasit. 37, 41.CrossRefGoogle Scholar
Kirby, W. M. M. & Rantz, L. A. (1943). J. exp. Med. 77, 29.CrossRefGoogle Scholar
Kritschewski, I. L. & Rubinstein, P. L. (1932). Z. ImmunForsch. 76, 506.Google Scholar
Kritschewski, I. L. & Halperin, E. P. (1933). Z. ImmunForsch. 79, 149.Google Scholar
Lankford, C. E., Scott, V. & Cooke, W. R. (1943). J. Bact. 45, 201.Google Scholar
Lourie, E. M. (1935). Ann. trop. Med. Parasit. 29, 421.CrossRefGoogle Scholar
Lourie, E. M. & Yorke, W. (1938). Ann. trop. Med. Parasit. 32, 201.CrossRefGoogle Scholar
Maegraith, B. G., Adams, A. R. D., King, J. D., Townshend, R. H., Davey, T. H. & Harvard, R. E. (1945). Ann. trop. Med. Parasit. 39, 232.CrossRefGoogle Scholar
Moldovan, J. (1912). Zbl. Bakt. 66, 105.Google Scholar
Nauck, E. G. (1934). Arch. Schiffs- u. Tropenhyg. 38, 313.Google Scholar
Sergent, Et. & , Ed. (1921 a). Bull. Soc. Path. exot. 14, 72.Google Scholar
Sergent, Et. & , Ed. (1921 b). Arch. Inst. Pasteur Afr. N. 1, 1.Google Scholar
Sesler, C. L. & Schmidt, L. H. (1942). J. Pharmacol. 75, 356.Google Scholar
Taliaferro, W. H. & Taliaferro, L. G. (1929). J. prev. Med., Baltimore, 3, 197.Google Scholar
Wasielewski, T. von (1902). Arch. Hyg., Berl., 41, 68.Google Scholar
Williamson, J., Bertram, D. S. & Lourie, E. M. (1947). Nature, Lond., 159, 885.CrossRefGoogle Scholar
Yorke, W., Murgatroyd, F. & Hawking, F. (1932). Ann. trop. Med. Parasit. 26, 577.CrossRefGoogle Scholar
Yorke, W., Murgatroyd, F. & Hawking, F. (1933 a). Brit. med. J. 1, 176.CrossRefGoogle Scholar
Yorke, W., Murgatroyd, F. & Hawking, F. (1933 b). Ann. trop. Med. Parasit. 27, 157.CrossRefGoogle Scholar