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Estimation of heritability of susceptibility to infection with Theileria parva in the tick Rhipicephalus appendiculatus

Published online by Cambridge University Press:  06 April 2009

A. S. Young ,
T. T. Dolan ,
F. N. Mwakima ,
H. Ochanda ,
S. N. Mwaura ,
G. M. Njihia ,
M. W. Muthoni  and
R. B. Dolan
A. S. Young
Affiliation:
International Livestock Research Institute, P.O. Box 30709, Nairobi, Kenya
T. T. Dolan
Affiliation:
International Livestock Research Institute, P.O. Box 30709, Nairobi, Kenya
F. N. Mwakima
Affiliation:
International Livestock Research Institute, P.O. Box 30709, Nairobi, Kenya
H. Ochanda
Affiliation:
International Livestock Research Institute, P.O. Box 30709, Nairobi, Kenya
S. N. Mwaura
Affiliation:
International Livestock Research Institute, P.O. Box 30709, Nairobi, Kenya
G. M. Njihia
Affiliation:
International Livestock Research Institute, P.O. Box 30709, Nairobi, Kenya
M. W. Muthoni
Affiliation:
International Livestock Research Institute, P.O. Box 30709, Nairobi, Kenya
R. B. Dolan
Affiliation:
Stockwatch Ltd, P.O. Box 24720, Nairobi, Kenya
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Summary

Heritability of susceptibility to infection with Theileria parva was estimated from full sib families of Rhipicephalus appendiculatus ticks. Male and female ticks of 2 stocks were mated singly. Nineteen full sib families of the Muguga stock and 17 full sib families of the Kiambu stock were obtained. Nymphae of these families were fed on cattle infected with T. parva so that the ticks became replete on days 16 and 17 after infection when the blood was parasitaemic with intraerythrocytic piroplasms. The T. parva infections were assessed in the resultant adult ticks of each full sib group and the abundance of infection, the number of salivary gland acini infected/tick, was found to be the most useful parameter for analysis. Estimates of heritability of the susceptibility to infection with T. parva for the Kiambu and the Muguga tick stocks were 0·24 and 0·26 respectively. Using only the data from ticks which fed on day 16, the heritability estimates were 0·39 for the Kiambu stock and 0·59 for the Muguga stock. These results indicate that tick lines of high or low susceptibility for T. parva infection could be produced through selection.

Keywords

Theileria parvaRhipicephalus appendiculatussusceptibility to infectionheritabilityselection.
Type
Research Article
Information
Parasitology , Volume 111 , Issue 1 , July 1995 , pp. 31 - 38
Copyright
Copyright © Cambridge University Press 1995

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References

REFERENCES

Al-Mashhadani, H. M., Davidson, G. & Curtis, C. F. (1980). A genetic study of the susceptibility of Anopheles gambiae to Plasmodium berghei. Transactions of the Royal Society of Tropical Medicine and Hygiene 74, 585–94.Google Scholar
Bailey, K. P. (1960). Notes on the rearing of Rhipicephalus appendiculatus and their infection with Theileria parva for experimental transmission. Bulletin of Epizootic Diseases of Africa 8, 330–4.Google Scholar
Büscher, G. & Otim, B. (1986). Quantitative studies on Theileria parva in the salivary glands of Rhipicephalus appendiculatus adults: quantitation and prediction of infection. International Journal for Parasitology 10, 93–100.CrossRefGoogle Scholar
Clayton, G. A., Morris, J. A. & Robertson, A. (1957). An experimental check on quantitative genetical theory. I. Short-term responses to selection. Journal of Genetics 55, 171–80.CrossRefGoogle Scholar
Collins, F. H., Sakai, R. K., Vernick, K. D., Paskewitz, S., Seeley, D. C., Miller, L. H., Collins, W. E., Campbell, C. C. & Gwadz, R. W. (1986). Genetic selection of a Plasmodium refractory strain of the malaria vector Anopheles gambiae. Science 234, 607–10.CrossRefGoogle ScholarPubMed
Crampton, J. M., Warren, A., Lycett, G. J., Hughes, M. A., Comley, I. P. & Eggleton, P. (1994). Genetic manipulation of insect vectors as a strategy for control of vector-borne disease. Annals of Tropical Medicine and Parasitology 88, 30–12.Google Scholar
Falconer, D. S. (1989). Introduction to Quantitative Genetics. 3rd Edn.Edinburgh: Oliver and Boyd.Google Scholar
Feldmann, A. M. & Ponnudurai, T. (1989). Selection of Anopheles stephensi for refractoriness and susceptibility to Plasmodium falciparum. Medical and Veterinary Entomology 3, 41–52.CrossRefGoogle ScholarPubMed
Goddeeris, B. M., Katende, J. M., Irvin, A. D. & Chumo, R. S. F. (1982). Indirect fluorescent antibody test for experimental and epizootiological studies on East Coast fever (Theileria parva infection in cattle). Evaluation of cell culture antigen fixed and stored in suspension. Research in Veterinary Science 33, 360–5.Google Scholar
Harvey, W. R. (1977). User's Guide for Least-Squares and Maximum Likelihood Computer Program. Columbus: Ohio State University.Google Scholar
Maudlin, I. (1976). Inheritance of susceptibility to Trypanosoma cruzi infection in Rhodnius prolixus. Nature, London 262, 214–15.CrossRefGoogle ScholarPubMed
Maudlin, I. (1982). Inheritance of susceptibility to Trypanosoma congolense infection in Glossina morsitans. Annals of Tropical Medicine and Parasitology 76, 225–7.CrossRefGoogle ScholarPubMed
Macdonald, W. W. (1962). Selection of a strain of Aedes aegypti susceptible to infection with semi-periodic Brugia malayi. Annals of Tropical Medicine and Hygiene 56, 368–82.Google Scholar
Macdonald, W. W. & Ramachandran, C. P. (1965). The influence of the gene fm (filarial susceptibility, Brugia malayi) on the susceptibility of Aedes aegypti to seven strains of Brugia, Wuchereria and Dirofilaria. Annals of Tropical Medicine and Parasitology 59, 640–73.CrossRefGoogle ScholarPubMed
Medley, G. F., Sinden, R. E., Fleck, S., Billingsby, P. F., Tirawanchai, N. & Rodriguez, M. H. (1993). Heterogeneity in patterns of malarial oocyst infection in the mosquito vector. Parasitology 106, 441–9.CrossRefGoogle ScholarPubMed
Mukhebi, A. W., Perry, B. D. & Kruska, R. (1992). Estimated economics of theileriosis control in Africa. Preventive Veterinary Medicine 12, 730–85.CrossRefGoogle Scholar
Musoke, A., Morzaria, S., Nkonge, C., Jones, E. & Nene, v. (1992). A recombinant sporozoite surface antigen of Theileria parva induces protection in cattle. Proceedings of the National Academy of Sciences, USA 89, 514–18.CrossRefGoogle ScholarPubMed
Norval, R. A. I., Perry, B. D. & Young, -A. S. (1992). The Epidemiology of Theileriosis in Africa. London: Academic Press.Google Scholar
Nuttall, G. H. F. (1915). Artificial parthenogenesis in ticks. Parasitology 7, 457–61.Google Scholar
Obiamiwe, B. A. & Macdonald, W. W. (1973). Evidence of a sex linked recessive gene, sb, controlling the susceptibility of Culex pipiens to Brugia pahangi. Transactions of the Royal Society of Tropical Medicine and Hygiene 67, 32–3.Google Scholar
Paterson, A. H., Danon, S., Hewitt, J. D., Zamir, D., Rabinowitch, H. D., Lincoln, S. E., Lander, E. S. & Tanksley, S. D. (1991). Mendelian factors underlying quantitative traits in tomato: comparison across species, generations and environments. Genetics 127, 181–97.CrossRefGoogle ScholarPubMed
Robertson, F. W. (1957). Studies in quantitative inheritance. X. Genetic variation of ovary size in Drosophila. Journal of Genetics, 55, 410–27.CrossRefGoogle Scholar
Shaw, M. K. & Young, A. S. (1994). The biology of Theileria species in ixodid ticks in relation to parasite transmission. Advances in Diseases Vector Research 10, 23–63.Google Scholar
Shrimpton, A. E. & Robertson, A. (1988). The isolation of factors controlling bristle score in Drosophila melanogaster. 1. Allocation of third chromosome bristle effects to chromosome sections. Genetics 118, 437–43.Google Scholar
Vernick, K. D. & Collins, F. H. (1989). Association of a Plasmodzum-refractory phenotype with an esterase locus in Anopheles gambiae. American Journal of Tropical Medicine and Hygiene 40, 593–7.Google Scholar
Vernick, K. D., Collins, F. H. & Gwadz, R. W. (1989). A general system of resistance to malaria infection in Anopheles gambiae controlled by two main genetic loci. American Journal of Tropical Medicine and Hygiene 40, 585–92.CrossRefGoogle ScholarPubMed
Wu, W. K. & Tesh, R. B. (1990 a). Selection of Phlebotomus papatasi (Diptera: Psychodidae) lines susceptible and refractory to Leishmania major infection. American Journal of Tropical Medicine and Hygiene 42, 320–8.CrossRefGoogle ScholarPubMed
Wu, W. K. & Tesh, R. B. (1990 b). Genetic factors controlling susceptibility to Leishmania major infection in the sand fly Phlebotomus papatasi (Diptera: Psychodidae). American Journal of Tropical Medicine and Hygiene 42, 329–34.Google Scholar
Young, A. S. & Leitch, B. L. (1981). Epidemiology of East Coast fever: some effects of temperature on the development of Theileria parva in the tick vector, Rhipicephalus appendiculatus. Parasitology 83, 199–211.Google Scholar