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Immune response of guinea-pigs to chemically abbreviated prepatent Metastrongylus apri infection

Published online by Cambridge University Press:  06 April 2009

V. Kumar  and
J. Mortelmans
V. Kumar
Affiliation:
Department of Veterinary Medicine, Institute of Tropical Medicine, 155-Nationalestraat, B 2000 Antwerpen, Belgium
J. Mortelmans
Affiliation:
Department of Veterinary Medicine, Institute of Tropical Medicine, 155-Nationalestraat, B 2000 Antwerpen, Belgium
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Summary

The effect of chemical abbreviation of the primary infection dose (PID) of 160 infective larvae of Metastrongylus apri on the immune status of the guinea-pig host was studied. The criteria used for assessing the status of immunity consisted of clinical manifestations following administration of a challenge infection dose (CID) of 800 infective larvae of M. apri, the rate of worm recovery 15 days post-CID and the rate of mortality following administration of CID.

Among the guinea-pigs of the main experimental group, where 15-day-old PID was abbreviated by two parenteral doses of levamisole, a strong immunity to CID given 35 days post-PID was built-up. Against this, all the guinea-pigs of a control group, which did not receive PID, died between 16 and 22 days post-CID.

The increase in serum gamma-globulin level of the guinea-pigs, where the PID was abbreviated chemically, suggested that the rise of this globulin fraction in the serum could be in some way related to the resistant state of guinea-pigs.

Type
Research Article
Information
Parasitology , Volume 72 , Issue 1 , February 1976 , pp. 13 - 18
Copyright
Copyright © Cambridge University Press 1976

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References

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