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Pathology of Angiostrongylus cantonensis infection in two model avian hosts

Published online by Cambridge University Press:  28 September 2020

Barbora Fecková Open the ORCID record for Barbora Fecková [Opens in a new window] ,
Priyanka Djoehana ,
Barbora Putnová ,
Michaela Valašťanová ,
Michaela Petríková ,
Zdeněk Knotek  and
David Modrý Open the ORCID record for David Modrý [Opens in a new window]
Barbora Fecková*
Affiliation:
Department of Pathology and Parasitology, University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1946/1, Brno, Czech Republic
Priyanka Djoehana
Affiliation:
Department of Pathology and Parasitology, University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1946/1, Brno, Czech Republic
Barbora Putnová
Affiliation:
Department of Pathology and Parasitology, University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1946/1, Brno, Czech Republic
Michaela Valašťanová
Affiliation:
Department of Pathology and Parasitology, University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1946/1, Brno, Czech Republic
Michaela Petríková
Affiliation:
Department of Pathology and Parasitology, University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1946/1, Brno, Czech Republic
Zdeněk Knotek
Affiliation:
Department of Pathology and Parasitology, University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1946/1, Brno, Czech Republic
David Modrý
Affiliation:
Department of Pathology and Parasitology, University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1946/1, Brno, Czech Republic Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic; Department of Botany and Zoology, Faculty of Science, Masaryk University, Brno, Czech Republic
*
Author for correspondence: Barbora Fecková, E-mail: feckovab@vfu.cz
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Abstract

Angiostrongylus cantonensis causes severe neurological disorders in a wide range of warm-blooded animals, including several avian species. A laboratory isolate of A. cantonensis originating from French Polynesia, genotyped as clade 2, was used to assess the effect of experimental infection in chicken and Japanese quail. Low dose groups of birds were infected orally by 100 L3 larvae, high dose groups by 1500 L3 larvae and the birds in the third group were fed three infected snails, mimicking a natural infection. Clinical signs during the first week after infection, haematology, biochemistry, gross lesions and histology findings were used to assess the pathology of the infection. Some of the infected birds showed peripheral eosinophilia, while mild neurological signs were seen in others. No larvae were observed in serial sections of the central nervous system of infected birds 1 week after infection and no major gross lesions were observed during necropsy; histopathology did not reveal lesions directly attributable to A. cantonensis infection. Our results suggest that galliform birds are not highly susceptible to A. cantonensis infection and open a question of the importance of Galliformes in endemic areas as natural pest control, lowering the number of hosts carrying the infective larvae.

Keywords

Angiostrongyluscantonensisexperimentalbirdchickenquail
Type
Research Article
Information
Parasitology , Volume 148 , Special Issue 2: 6th International Workshop on Angiostrongylus and Angiostrongyliasis, Hilo, Hawai'i, USA, January, 2020 , February 2021 , pp. 174 - 177
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Copyright
Copyright © The Author(s) 2020. Published by Cambridge University Press

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