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Praziquantel treatment of Biomphalaria glabrata infected with Schistosoma mansoni– influence on snail fecundity

Published online by Cambridge University Press:  06 April 2009

E. M. Riley  and
L. H. Chappell
E. M. Riley
Affiliation:
Department of Zoology, University of Aberdeen, Tillydrone Avenue, Aberdeen AB9 2TN
L. H. Chappell
Affiliation:
Department of Zoology, University of Aberdeen, Tillydrone Avenue, Aberdeen AB9 2TN
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Extract

Praziquantel, administered over a 72 h period in the food of mature Biomphalaria glabrata harbouring 7-week-old Schistosoma mansoni infections, dramatically reduced the numbers of cercariae shed. Doses of 20–30 μg/g body weight (including shell weight) reduced shedding by 85–95% over 5 weeks before recovery was evident. Suppression of cercarial shedding in these infections was accompanied by the temporary recovery of the snail reproductive regression due to S. mansoni infection. Snail fecundity was subsequently re-suppressed 2 weeks prior to recovery of the parasite as evidenced by a resumption of cercarial shedding. Praziquantel destroyed mature and developing cercariae within the daughter sporocysts but had no apparent effect on daughter sporocysts; this may account for the eventual resumption of cercarial production. Reproductive failure of the snail is apparently related to the latter stages of cercarial development specifically. Reproductive recovery did not occur when snails were infected as juveniles or when mature-infected snails harboured 12–5 week i.e. older infections: drug treatment temporarily inhibited cercarial production but no snails produced eggs.

Keywords

Schistosoma mansoniBiomphalaria glabratapraziquantelfecundity
Type
Research Article
Information
Parasitology , Volume 101 , Issue 2 , October 1990 , pp. 211 - 217
Copyright
Copyright © Cambridge University Press 1990

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References

Andrews, P. (1978). Effect of praziquantel on the free-living stages of Schistosoma mansoni. Zeitschrift für Parasitenkunde 56, 99–106.CrossRefGoogle ScholarPubMed
Andrews, P., Thomas, H., Pohlke, R. & Seubert, J. (1983). Praziquantel. Medical Research Review 3, 147–200.CrossRefGoogle ScholarPubMed
Becker, B., Melhorn, H., Andrews, P. & Thomas, H. (1981). Ultrastructural investigations on the effect of praziquantel on the tegument of five species of cestodes. Zeitschrift für Parasitenkunde 64, 257–69.CrossRefGoogle ScholarPubMed
Becker, W. (1980). Metabolic interrelationship of parasitic trematodes and molluscs, especially Schistosoma mansoni in Biomphalaria glabrata. Zeitschrift für Parasitenkunde 63, 101–11.CrossRefGoogle ScholarPubMed
Björklund, H. & Bylund, G. (1987). Absorption, distribution and excretion of the anthelmintic praziquantel (Droncit) in the rainbow trout (Salmo gairdneri R). Parasitology Research 73, 240–4.CrossRefGoogle ScholarPubMed
Chappell, L. H. (1988). Interaction between drugs and the parasite surface. Parasitology 96, (Suppl.), S167–S193.CrossRefGoogle ScholarPubMed
Coelho, P. M. Z., Katz, N., Rocha, M. O. E., De Souza, C. P. & Mello, R. T. (1988). Schistosomiasis mansoni: infected snails as a tool to screen antischistosomal drugs. International Journal for Parasitology 18, 167–70.CrossRefGoogle Scholar
Crews, A. E. & Yoshino, T. P. (1989). Schistosoma mansoni: effect of infection on reproduction and gonadal growth in Biomphalaria glabrata. Experimental Parasitology 68, 326–34.CrossRefGoogle ScholarPubMed
De Jong-Brink, M., Elsaadany, M. M. & Boer, H. H. (1988 a). Trichobilharzia ocellata: interference with endocrine control of female reproduction of Lymnaea stagnalis. Experimental Parasitology 65, 91–100.CrossRefGoogle ScholarPubMed
De Jong-Brink, M., Elsaadany, M. M. & Boer, H. H. (1988 b). Schistosomin, an antagonist of calfluxin. Experimental Parasitology 65, 109–18.CrossRefGoogle ScholarPubMed
Etges, F. J. & Gresso, W. (1965). Effect of Schistosoma mansoni infection upon fecundity in Australorbis glabratus. Journal of Parasitology 51, 757–60.CrossRefGoogle ScholarPubMed
Gönnert, R. & Andrews, P. (1977). Praziquantel, a new broad-spectrum antischistosomal agent. Zeitschrift für Parasitenkunde 52, 129–50.CrossRefGoogle Scholar
Hurd, H. (1990). Physiological and behavioural interactions between parasites and invertebrate hosts. Advances in Parasitology 29, 271–318.CrossRefGoogle ScholarPubMed
Joosse, J., van Elk, R., Mosselman, S., WortelBoer, H. & van Diepen, J. C. E. (1988). Schistosomin: a pronase-sensitive agent in the haemolymph of Trichobilharzia ocellata-iniected Lymnaea stagnalis inhibits the activity of albumen glands in vitro. Parasitology Research 74, 228–34.CrossRefGoogle ScholarPubMed
Meier, M. & Meier-Brook, C. (1981). Schistosoma mansoni: effect on growth, fertility, and development of distal male organs in Biomphalaria glabrata exposed to miracidia at different ages. Zeitschrift für Parasitenkunde 66, 121–31.CrossRefGoogle ScholarPubMed
Meuleman, E. A. (1972). Host-parasite interrelationships between the freshwater pulmonate Biomphalaria pfeifferi and the trematode Schistosoma mansoni. Netherlands Journal of Zoology 22, 355–427.CrossRefGoogle Scholar
Pan, C. (1965). Studies on the host-parasite relationship between Schistosoma mansoni and the snail Australorbis glabratus. American Journal of Tropical Medicine and Hygiene 14, 931–76.CrossRefGoogle ScholarPubMed
Pearson, E. J. & Cheng, T. C. (1985). Studies on parasitic castration: occurrence of a gametogenesis-inhibiting factor in extract of Zoogonus lasius (Trematoda). Journal of Invertebrate Pathology 46, 239–46.CrossRefGoogle Scholar
Richards, F., Sullivan, J. & Ruiz-Tiben, E., Eberhard, M. & Bishop, H. (1989). Effect of praziquantel on the eggs of Schistosoma mansoni, with a note on the implications for managing central nervous system schistosomiasis. Annals of Tropical Medicine and Parasitology 83, 465–72.CrossRefGoogle ScholarPubMed
Shaw, M. K. (1990). Schistosoma mansoni: stage-dependent damage after in vivo treatment with praziquantel. Parasitology 100, 65–72.CrossRefGoogle ScholarPubMed
Sluiters, J. F., Brussaard-Wüst, C. M. & Meuleman, E. A. (1980). The relationship between miracidial dose, production of cercariae and reproductive activity of the host in the combination Trichobilharzia ocellata and Lymnaea stagnalis. Zeitschrift für Parasitenkunde 63, 13–26.CrossRefGoogle ScholarPubMed
Standen, O. D. (1951). Some observations upon the maintenance of Australorbis glabratus in the laboratory. Annals of Tropical Medicine and Parasitology 45, 80–3.CrossRefGoogle ScholarPubMed
Sturrock, B. M. (1966). The influence of infection with Schistosoma mansoni on the growth rate and reproduction of Biomphalaria pfeifferi. Annals of Tropical Medicine and Parasitology 60, 187–97.CrossRefGoogle ScholarPubMed
Thornhill, J. A., Jones, J. T. & Kusel, J. R. (1986). Increased oviposition and growth in immature Biomphalaria glabrata after exposure to Schistosoma mansoni. Parasitology 93, 443–50.CrossRefGoogle ScholarPubMed
Ulmer, M. J. (1970). Notes on rearing snails in the laboratory. In Experiments and Techniques in Parasitology, (ed. Maclnnis, A. J. & Voge, M.). pp. 143–144. San Francisco: Freeman and Company.Google Scholar
Warren, S. K. (1967). Studies on the treatment of molluscan schistosomiasis mansoni with antibiotics, non-antibiotic metabolic inhibitors, molluscicides and anti-schistosomal agents. Transactions of the Royal Society of Tropical Medicine and Hygiene 61, 368–72.CrossRefGoogle Scholar
Warren, S. K. & Weisberger, A. S. (1966). The treatment of molluscan schistosomiasis with chloramphenicol. American Journal of Tropical Medicine and Hygiene 61, 368–72.CrossRefGoogle Scholar
Wilson, R. A. & Denison, J. (1980). The parasitic castration and gigantism of Lymnaea truncatula infected with the larval stages of Fasciola hepatica. Zeitschrift für Parasitenkunde 61, 109–19.CrossRefGoogle ScholarPubMed
Xiao, S. H., Catto, B. A. & Webster, L. T. (1983). Quantitative determination of praziquantel in serum by high performance liquid chromatography. Journal of Chromatography 275, 127–32.CrossRefGoogle ScholarPubMed