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The stability of resistance to diminazene aceturate and quinapyramine sulphate in a strain of Trypanosoma vivax during cyclical transmission through antelope

Published online by Cambridge University Press:  06 April 2009

A. R. Gray  and
C. J. Roberts
A. R. Gray
Affiliation:
The Nigerian Institute for Trypanosomiasis Research, VomBenue-Plateau State, Nigeria
C. J. Roberts
Affiliation:
The Nigerian Institute for Trypanosomiasis Research, VomBenue-Plateau State, Nigeria
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Extract

A drug-resistant strain of T. vivax was transmitted through a series of four duikers (S. grimmia) and a gazelle (G. rufifrons) by G. palpalis and G. tachinoides. The cyclical transmission of the strain in cattle, started in earlier work, was continued for control purposes. Infections with the drug-resistant strain in the antelope were of the same type as those produced by field strains of T. vivax in the same host species, and infection rates in tsetse flies fed at early stages of infection on the antelope were similar to those found in flies fed on cattle infected with the drug-resistant strain. The strain retained resistance to diminazene aceturate at a dose rate of 7-0 mg/kg and quinapyramine sulphate at 5'0 mg/kg in the absence of the drugs for 7 months in tsetse flies and antelope, and for a total period of 29 months in tsetse flies and cattle.

We wish to thank Dr A. A. Amodu, Director of the Nigerian Institute for Trypanosomiasis Research, for permission to publish this paper.

Type
Research Article
Information
Parasitology , Volume 63 , Issue 1 , August 1971 , pp. 163 - 168
Copyright
Copyright © Cambridge University Press 1971

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References

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