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Anthelmintic resistance and novel control options in equine gastrointestinal nematodes

Published online by Cambridge University Press:  05 November 2018

Ali Raza Open the ORCID record for Ali Raza [Opens in a new window] ,
Abdul Ghaffar Qamar ,
Khizar Hayat ,
Shoaib Ashraf  and
Andrew R. Williams
Ali Raza*
Affiliation:
Faculty of Veterinary Science, Department of Clinical Medicine and Surgery, University of Agriculture, Faisalabad, Punjab, Pakistan
Abdul Ghaffar Qamar
Affiliation:
Faculty of Veterinary Science, Department of Clinical Medicine and Surgery, University of Agriculture, Faisalabad, Punjab, Pakistan
Khizar Hayat
Affiliation:
Faculty of Veterinary Science, Department of Anatomy, University of Agriculture, Faisalabad, Punjab, Pakistan
Shoaib Ashraf
Affiliation:
Wellman Centre for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, USA
Andrew R. Williams
Affiliation:
Faculty of Health and Medical Sciences, Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark
*
Author for correspondence: Ali Raza, E-mail: a.raza@uq.edu.au
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Abstract

Control of equine nematodes has relied on benzimidazoles (BZs), tetrahydropyrimidines and macrocyclic lactones. The intensive use of anthelmintics has led to the development of anthelmintic resistance (AR) in equine cyathostomins and Parascaris equorum. Field studies indicate that BZ and pyrantel resistance is widespread in cyathostomins and there are also increasing reports of resistance to macrocyclic lactones in cyathostomins and P. equorum. The unavailability of reliable laboratory-based techniques for detecting resistance further augments the problem of nematode control in horses. The only reliable test used in horses is the fecal egg count reduction test; therefore, more focus should be given to develop and validate improved methodologies for diagnosing AR at an early stage, as well as determining the mechanisms involved in resistance development. Therefore, equine industry and researchers should devise and implement new strategies for equine worm control, such as the use of bioactive pastures or novel feed additives, and control should increasingly incorporate alternative and evidence-based parasite control strategies to limit the development of AR. This review describes the history and prevalence of AR in equine nematodes, along with recent advances in developing resistance diagnostic tests and worm control strategies in horses, as well as giving some perspective on recent research into novel control strategies.

Keywords

Anthelmintic resistancedevelopmentdiagnosisequinesgastrointestinal nematodeshistorymanagement of anthelmintic resistanceplant bioactivesprevalence
Type
Review Article
Information
Parasitology , Volume 146 , Issue 4 , April 2019 , pp. 425 - 437
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Copyright © Cambridge University Press 2018 

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