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Applicability of plant-based products in the treatment of Trypanosoma cruzi and Trypanosoma brucei infections: a systematic review of preclinical in vivo evidence

Published online by Cambridge University Press:  05 June 2017

RODRIGO M. PEREIRA ,
GLÍCIA M. Z. GRECO ,
ANDREIA M. MOREIRA ,
PABLO F. CHAGAS ,
IVO S. CALDAS ,
REGGIANI V. GONÇALVES  and
RÔMULO D. NOVAES
RODRIGO M. PEREIRA
Affiliation:
Institute of Biomedical Sciences, Federal University of Alfenas, 37130-001, Minas Gerais, Brazil Postgraduate Program in Biosciences Applied to Health, Federal University of Alfenas, 37130-001, Minas Gerais, Brazil
GLÍCIA M. Z. GRECO
Affiliation:
Institute of Biomedical Sciences, Federal University of Alfenas, 37130-001, Minas Gerais, Brazil Postgraduate Program in Biosciences Applied to Health, Federal University of Alfenas, 37130-001, Minas Gerais, Brazil
ANDREIA M. MOREIRA
Affiliation:
Institute of Biomedical Sciences, Federal University of Alfenas, 37130-001, Minas Gerais, Brazil Postgraduate Program in Biosciences Applied to Health, Federal University of Alfenas, 37130-001, Minas Gerais, Brazil
PABLO F. CHAGAS
Affiliation:
Institute of Biomedical Sciences, Federal University of Alfenas, 37130-001, Minas Gerais, Brazil Postgraduate Program in Biological Sciences, Federal University of Alfenas, 37130–001, Minas Gerais, Brazil
IVO S. CALDAS
Affiliation:
Institute of Biomedical Sciences, Federal University of Alfenas, 37130-001, Minas Gerais, Brazil
REGGIANI V. GONÇALVES
Affiliation:
Department of Animal Biology, Federal University of Viçosa, 36570-000, Minas Gerais, Brazil
RÔMULO D. NOVAES*
Affiliation:
Institute of Biomedical Sciences, Federal University of Alfenas, 37130-001, Minas Gerais, Brazil
*
*Corresponding author: Institute of Biomedical Sciences, Department of Structural Biology, Federal University of Alfenas, Rua Gabriel Monteiro da Silva, 700, Alfenas, 37130-001, Minas Gerais, Brazil. E-mail: romulo.novaes@unifal-mg.edu.br
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Summary

Chagas disease and sleeping sickness are neglected tropical diseases closely related to poverty, for which the development of plant-derived treatments has not been a promising prospect. Thus, we systematicaly review the preclinical in vivo evidence on the applicability of plant-based products in the treatment of Trypanosoma cruzi and Trypanosoma brucei infections. Characteristics such as disease models, treatments, toxicological safety and methodological bias were analysed. We recovered 66 full text articles from 16 countries investigating 91 plant species. The disease models and treatments were highly variable. Most studies used native (n = 36, 54·54%) or exotic (n = 30, 45·46%) plants with ethnodirected indication (n = 45, 68·18%) for trypanosomiasis treatment. Complete phytochemical screening and toxicity assays were reported in only 15 (22·73%) and 32 (48·49%) studies, respectively. The currently available preclinical evidence is at high risk of bias. The absence of or incomplete characterization of animal models, treatment protocols, and phytochemical/toxicity analyses impaired the internal validity of the individual studies. Contradictory results of a same plant species compromise the external validity of the evidence, making it difficult determine the effectiveness, safety and biotechnological potential of plant-derived products in the development of new anti-infective agents to treat T. cruzi and T. brucei infections.

Keywords

Experimental therapeuticshuman trypanosomiasisneglected diseasesparasitic diseasesparasitology
Type
Review Article
Information
Parasitology , Volume 144 , Issue 10 , September 2017 , pp. 1275 - 1287
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Copyright © Cambridge University Press 2017 

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