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Bloodstream form trypanosome plasma membrane proteins: antigenic variation and invariant antigens

Published online by Cambridge University Press:  29 January 2010

ANGELA SCHWEDE  and
MARK CARRINGTON
ANGELA SCHWEDE*
Affiliation:
Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CambridgeCB2 1GA, UK
MARK CARRINGTON*
Affiliation:
Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CambridgeCB2 1GA, UK
*
*Corresponding author: mc115@cam.ac.uk
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Summary

Trypanosoma brucei is exposed to the adaptive immune system and complement in the blood of its mammalian hosts. The aim of this review is to analyse the role and regulation of the proteins present on the external face of the plasma membrane in the long-term persistence of an infection and transmission. In particular, the following are addressed: (1) antigenic variation of the variant surface glycoprotein (VSG), (2) the formation of an effective VSG barrier shielding invariant surface proteins, and (3) the rapid uptake of VSG antibody complexes combined with degradation of the immunoglobulin and recycling of the VSG.

Keywords

TrypanosomeVSGantigenic variation
Type
Research Article
Information
Parasitology , Volume 137 , Special Issue 14: African trypanosomiasis: New insights for disease control , December 2010 , pp. 2029 - 2039
Copyright
Copyright © Cambridge University Press 2010

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