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Brugia malayi microfilariae share epitopes with Aedes aegypti

Published online by Cambridge University Press:  06 April 2009

Miriam Lastre ,
J. Y. Cesbron ,
O. Perez ,
D. Henry ,
A. Ouaissi ,
C. Dissous  and
A. Capron
Miriam Lastre
Affiliation:
Centre d'Immunologie et de Biologie Parasitaire, Unité Mixte INSERM U 167 - CNRS 624, Institut Pasteur, 1 rue du Pr A. Calmette, 59019 - Lille Cédex, France
J. Y. Cesbron*
Affiliation:
Centre d'Immunologie et de Biologie Parasitaire, Unité Mixte INSERM U 167 - CNRS 624, Institut Pasteur, 1 rue du Pr A. Calmette, 59019 - Lille Cédex, France
O. Perez
Affiliation:
Centre d'Immunologie et de Biologie Parasitaire, Unité Mixte INSERM U 167 - CNRS 624, Institut Pasteur, 1 rue du Pr A. Calmette, 59019 - Lille Cédex, France
D. Henry
Affiliation:
Centre d'Immunologie et de Biologie Parasitaire, Unité Mixte INSERM U 167 - CNRS 624, Institut Pasteur, 1 rue du Pr A. Calmette, 59019 - Lille Cédex, France
A. Ouaissi
Affiliation:
Centre d'Immunologie et de Biologie Parasitaire, Unité Mixte INSERM U 167 - CNRS 624, Institut Pasteur, 1 rue du Pr A. Calmette, 59019 - Lille Cédex, France
C. Dissous
Affiliation:
Centre d'Immunologie et de Biologie Parasitaire, Unité Mixte INSERM U 167 - CNRS 624, Institut Pasteur, 1 rue du Pr A. Calmette, 59019 - Lille Cédex, France
A. Capron
Affiliation:
Centre d'Immunologie et de Biologie Parasitaire, Unité Mixte INSERM U 167 - CNRS 624, Institut Pasteur, 1 rue du Pr A. Calmette, 59019 - Lille Cédex, France
*
†Reprint requests to Dr J. Y. Cesbron.
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Summary

Shared antigens between Brugia malayi and Aedes aegypti were studied. The experiments carried out with sera from infected Mastomys natalensis indicated that an immunological response against A. aegypti antigens (Mr 185, 35, 32 kDa) appeared often when animals became microfilaraemic and increased progressively in intensity during the time-course of infection. Sera of animals immunized with B. malayi reacted with the crude extract of mosquitoes and conversely, antibodies from animals immunized with A. aegypti reacted with the surface of B. malayi microfilariae. The implications of these findings for the natural history of B. malayi infection are discussed.

Type
Research Article
Information
Parasitology , Volume 97 , Issue 2 , October 1988 , pp. 247 - 254
Copyright
Copyright © Cambridge University Press 1988

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Footnotes

*

Instituto de Medicina Tropical ‘Pedro Kouri’, zona postal 13, Aptdo. 601 Marianao, C. Habana, Cuba.

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