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Cellular immune response in intraventricular experimental neurocysticercosis

Published online by Cambridge University Press:  02 December 2015

VANIA B. L. MOURA ,
SARAH B. LIMA ,
HIDELBERTO MATOS-SILVA ,
MARINA C. VINAUD ,
PATRICIA R. A. N. LOYOLA  and
RUY S. LINO JR.
VANIA B. L. MOURA
Affiliation:
Department of Microbiology, Immunology, Parasitology and Pathology, Tropical Pathology and Public Health Institute, Federal University of Goias,– Rua 235 S/N, Setor Universitário, 74605-050, Goiânia, Goiás, Brazil
SARAH B. LIMA
Affiliation:
Tropical Pathology and Public Health Post-graduation Programme, Tropical Pathology and Public Health Institute, Federal University of Goias,– Rua 235 S/N, Setor Universitário, 74605-050, Goiânia, Goiás, Brazil
HIDELBERTO MATOS-SILVA
Affiliation:
Tropical Pathology and Public Health Post-graduation Programme, Tropical Pathology and Public Health Institute, Federal University of Goias,– Rua 235 S/N, Setor Universitário, 74605-050, Goiânia, Goiás, Brazil
MARINA C. VINAUD
Affiliation:
Department of Microbiology, Immunology, Parasitology and Pathology, Tropical Pathology and Public Health Institute, Federal University of Goias,– Rua 235 S/N, Setor Universitário, 74605-050, Goiânia, Goiás, Brazil
PATRICIA R. A. N. LOYOLA
Affiliation:
Department of Microbiology, Immunology, Parasitology and Pathology, Tropical Pathology and Public Health Institute, Federal University of Goias,– Rua 235 S/N, Setor Universitário, 74605-050, Goiânia, Goiás, Brazil
RUY S. LINO JR.*
Affiliation:
Department of Microbiology, Immunology, Parasitology and Pathology, Tropical Pathology and Public Health Institute, Federal University of Goias,– Rua 235 S/N, Setor Universitário, 74605-050, Goiânia, Goiás, Brazil
*
*Corresponding author. Department of Microbiology, Immunology, Parasitology and Pathology, Tropical Pathology and Public Health Institute, Federal University of Goias,– Rua 235 S/N, Setor Universitário, 74605-050, Goiânia, Goiás, Brazil. E-mail: ruylino@yahoo.com.br
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Summary

Neurocysticercosis (NCC) is considered a neglected parasitic infection of the human central nervous system. Its pathogenesis is due to the host immune response, stage of evolution and location of the parasite. The aim of this study was to evaluate the in situ and systemic immune response through cytokines dosage (IL-4, IL-10, IL-17 and IFN-γ) as well as the local inflammatory response of the experimental NCC with Taenia crassiceps. The in situ and systemic cellular and inflammatory immune response were evaluated through the cytokines quantification at 7, 30, 60 and 90 days after inoculation and histopathological analysis. All cysticerci were found within the cerebral ventricles. There was a discrete intensity of inflammatory cells of mixed immune profile, polymorphonuclear and mononuclear cells, at the beginning of the infection and predominance of mononuclear cells at the end. The systemic immune response showed a significant increase in all the analysed cytokines and predominance of the Th2 immune profile cytokines at the end of the infection. These results indicate that the location of the cysticerci may lead to ventriculomegaly. The acute phase of the infection showed a mixed Th1/Th17 profile accompanied by high levels of IL-10 while the late phase showed a Th2 immune profile.

Keywords

Neurocysticercosisimmune profilecytokinesinflammationTaenia crassiceps
Type
Research Article
Information
Parasitology , Volume 143 , Issue 3 , March 2016 , pp. 334 - 342
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Copyright
Copyright © Cambridge University Press 2015 

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