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Characteristics of granuloma formation and liver fibrosis in murine schistosomiasis mekongi: a morphological comparison between Schistosoma mekongi and S. japonicum infection

Published online by Cambridge University Press:  21 June 2010

M. SHIMADA ,
M. KIRINOKI ,
K. SHIMIZU ,
N. KATO-HAYASHI ,
Y. CHIGUSA ,
V. KITIKOON ,
P. PONGSASAKULCHOTI  and
H. MATSUDA
M. SHIMADA
Affiliation:
Laboratory of Tropical Medicine and Parasitology, Dokkyo Medical University, Mibu, Shimotsuga, Tochigi 321-0293, Japan Department of Internal Medicine, Ashikaga Red Cross Hospital, Ashikaga, Tochigi 326-0808, Japan
M. KIRINOKI
Affiliation:
Laboratory of Tropical Medicine and Parasitology, Dokkyo Medical University, Mibu, Shimotsuga, Tochigi 321-0293, Japan
K. SHIMIZU
Affiliation:
Department of Pathology, Ashikaga Red Cross Hospital, Ashikaga, Tochigi 326-0808, Japan
N. KATO-HAYASHI
Affiliation:
Laboratory of Tropical Medicine and Parasitology, Dokkyo Medical University, Mibu, Shimotsuga, Tochigi 321-0293, Japan
Y. CHIGUSA*
Affiliation:
Laboratory of Tropical Medicine and Parasitology, Dokkyo Medical University, Mibu, Shimotsuga, Tochigi 321-0293, Japan
V. KITIKOON
Affiliation:
Department of Social and Environmental Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand
P. PONGSASAKULCHOTI
Affiliation:
Department of Social and Environmental Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand
H. MATSUDA
Affiliation:
Institute of International Education and Research, Dokkyo Medical University, Mibu, Shimotsuga, Tochigi 321-0293, Japan
*
*Corresponding author: Laboratory of Tropical Medicine and Parasitology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321-0293, Japan. Tel: +81 282 87 2134. Fax: +81 282 86 6431. E-mail: ychigusa@dokkyomed.ac.jp
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Summary

A histopathological study was performed to clarify the characteristics of granuloma formation and liver fibrosis in Schistosoma mekongi infection in comparison with S. japonicum infection. Mice were exposed to S. mekongi (Laotian strain) and S. japonicum (Japanese strain) cercariae, and were dissected at 6, 8, 12, 16, and 20 weeks post-exposure. In the liver, granulomas in S. mekongi infection were cellular, initially organized with foam cells, and continuously appeared in the intralobular area, while granulomas in S. japonicum infection were fibrous and did not continuously appear in the intralobular area. Portal fibrosis was not seen in S. mekongi infection, but was commonly seen in S. japonicum infection in the later weeks. Granulomas in the small intestine were seen mainly in the submucosa with foam cells in S. mekongi infection and without foam cells in S. japonicum infection. The lung granulomas contained mainly histiocytes in both S. mekongi and S. japonicum infection. The absence of portal fibrosis in S. mekongi infection allows schistosome eggs to infiltrate into the intralobular area continuously, which can be what lies behind the ultrasonographic differences; the echogenic network pattern as was seen in S. japonicum infection, has not been noted in S. mekongi infection.

Keywords

Schistosoma mekongigranuloma formationfoam cells
Type
Research Article
Information
Parasitology , Volume 137 , Issue 12 , October 2010 , pp. 1781 - 1789
Copyright
Copyright © Cambridge University Press 2010

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