Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-10T22:18:57.861Z Has data issue: false hasContentIssue false
  • English
  • Français

Characteristics of granuloma formation and liver fibrosis in murine schistosomiasis mekongi: a morphological comparison between Schistosoma mekongi and S. japonicum infection

Published online by Cambridge University Press:  21 June 2010

M. SHIMADA ,
M. KIRINOKI ,
K. SHIMIZU ,
N. KATO-HAYASHI ,
Y. CHIGUSA ,
V. KITIKOON ,
P. PONGSASAKULCHOTI  and
H. MATSUDA
M. SHIMADA
Affiliation:
Laboratory of Tropical Medicine and Parasitology, Dokkyo Medical University, Mibu, Shimotsuga, Tochigi 321-0293, Japan Department of Internal Medicine, Ashikaga Red Cross Hospital, Ashikaga, Tochigi 326-0808, Japan
M. KIRINOKI
Affiliation:
Laboratory of Tropical Medicine and Parasitology, Dokkyo Medical University, Mibu, Shimotsuga, Tochigi 321-0293, Japan
K. SHIMIZU
Affiliation:
Department of Pathology, Ashikaga Red Cross Hospital, Ashikaga, Tochigi 326-0808, Japan
N. KATO-HAYASHI
Affiliation:
Laboratory of Tropical Medicine and Parasitology, Dokkyo Medical University, Mibu, Shimotsuga, Tochigi 321-0293, Japan
Y. CHIGUSA*
Affiliation:
Laboratory of Tropical Medicine and Parasitology, Dokkyo Medical University, Mibu, Shimotsuga, Tochigi 321-0293, Japan
V. KITIKOON
Affiliation:
Department of Social and Environmental Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand
P. PONGSASAKULCHOTI
Affiliation:
Department of Social and Environmental Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand
H. MATSUDA
Affiliation:
Institute of International Education and Research, Dokkyo Medical University, Mibu, Shimotsuga, Tochigi 321-0293, Japan
*
*Corresponding author: Laboratory of Tropical Medicine and Parasitology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321-0293, Japan. Tel: +81 282 87 2134. Fax: +81 282 86 6431. E-mail: ychigusa@dokkyomed.ac.jp
Get access Rights & Permissions [Opens in a new window]

Summary

A histopathological study was performed to clarify the characteristics of granuloma formation and liver fibrosis in Schistosoma mekongi infection in comparison with S. japonicum infection. Mice were exposed to S. mekongi (Laotian strain) and S. japonicum (Japanese strain) cercariae, and were dissected at 6, 8, 12, 16, and 20 weeks post-exposure. In the liver, granulomas in S. mekongi infection were cellular, initially organized with foam cells, and continuously appeared in the intralobular area, while granulomas in S. japonicum infection were fibrous and did not continuously appear in the intralobular area. Portal fibrosis was not seen in S. mekongi infection, but was commonly seen in S. japonicum infection in the later weeks. Granulomas in the small intestine were seen mainly in the submucosa with foam cells in S. mekongi infection and without foam cells in S. japonicum infection. The lung granulomas contained mainly histiocytes in both S. mekongi and S. japonicum infection. The absence of portal fibrosis in S. mekongi infection allows schistosome eggs to infiltrate into the intralobular area continuously, which can be what lies behind the ultrasonographic differences; the echogenic network pattern as was seen in S. japonicum infection, has not been noted in S. mekongi infection.

Keywords

Schistosoma mekongigranuloma formationfoam cells
Type
Research Article
Information
Parasitology , Volume 137 , Issue 12 , October 2010 , pp. 1781 - 1789
Copyright
Copyright © Cambridge University Press 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Brown, M. S. and Goldstein, J. L. (1983). Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis. Annual Review of Biochemistry 52, 223–261.CrossRefGoogle ScholarPubMed
Buchanan, W. M. and Gelfand, M. (1970). Two cases of cor pulmonale caused by adult schistosome parasites in the lungs. Journal of Tropical Medicine and Hygiene 73, 218–222.Google ScholarPubMed
Byram, J. E., Imohiosen, E. A.E. and von Lichtenberg, F. (1978). Tissue eosinophil proliferation and maturation in schistosome-infected mice and hamsters. American Journal of Tropical Medicine and Hygiene 27, 267–270.CrossRefGoogle Scholar
Byram, J. E. and von Lichtenberg, F. (1980). Experimental infection with Schistosoma mekongi in laboratory animals: parasitological and pathological findings. Malacological Review 2 (Suppl.), 125–159.Google Scholar
Cheever, A. W., Duvall, R. H. and Minker, R. G. (1980). Extrahepatic pathology in rabbits infected with Japanese and Philippine strains of Schistosoma japonicum, and the relation of intestinal lesions to passage of eggs in the feces. American Journal of Tropical Medicine and Hygiene 29, 1316–1326.CrossRefGoogle ScholarPubMed
Dupont, V., Bernard, E., Soubrane, J., Halle, B. and Richter, C. (1957). Bilharzoise a Schistosoma japonicum a forme hepoto-spelnique revelee par une grande hematemese. Bulletins et Mémoires de la Société Médicale des Hôpitaux de Paris 73, 933–941.Google Scholar
Hirata, M., Takushima, M., Kage, M. and Fukuma, T. (1993). Comparative analysis of hepatic, pulmonary, and intestinal granuloma formation around freshly laid Schistosoma japonicum eggs in mice. Parasitology Research 79, 316–321.CrossRefGoogle ScholarPubMed
Hirose, Y., Matsumoto, J., Kirinoki, M., Shimada, M., Chigusa, Y., Nakamura, S., Sinuon, M., Socheat, D., Kitikoon, V. and Matsuda, H. (2007). Schistosoma mekongi and Schistosoma japonicum: Differences in the distribution of eggs in the viscera of mice. Parasitology International 56, 239–241.Google Scholar
Inokuchi, T., Maki, K. and Tsutsumi, H. (1979). Pulmonary lesions in rabbits with experimental Schistosomiasis japonica. Kurume Medical Journal 26, 1–9.CrossRefGoogle ScholarPubMed
Maeda, S., Irie, Y. and Yasuraoka, K. (1982). Resistance of mice to secondary infection with Schistosoma japonicum, with special reference to neutrophil enriched response to schisosomula in skin of immune mice. Japanese Journal of Experimental Medicine 52, 111–118.Google ScholarPubMed
Monchy, D., Dumurgier, C., Heng, T. K., Hong, K., Khun, H., Hou, S. V., Sok, K. E. and Huerrre, M. R. (2006). Lesions histologiques hepatiques de la schistosomose due a Schistosoma mekongi. A propos de six cas avec hytertension portale secere operes au Cambodge. Bulletin de la Société de Pathologie Exotique 99, 359–364.Google Scholar
Murakami, H. (1986). Image diagnosis of schistosomiasis japonica; comparison ultrasonogram with CT image. Journal of the Kurume Medical Association 49, 458–474.Google Scholar
Naito, M. and Takahashi, K. (1991). The role of Kupffer cells in glucan-induced granuloma formation in the liver of mice depleted of blood monocytes by administration of strontium-89. Laboratory Investigation 64, 664–674.Google ScholarPubMed
Ohmae, H., Sinuon, M., Kirinoki, M., Matsumoto, J., Chigusa, Y., Socheat, D. and Matsuda, H. (2004). Schistosomiasis mekongi: from discovery to control. Parasitology International 53, 135–142.CrossRefGoogle ScholarPubMed
Oshima, S., Yasuraoka, K., Irie, Y., Blas, B. L., Noseñas, J. S. and Santos, A. T. Jr. (1978). Final localization of Schistosoma japonicum in the lungs of field rats, Rattus mindanensis, in Leyte, Philippines. Japanese Journal of Experimental Medicine 48, 503–509.Google ScholarPubMed
Owhashi, M., Maruyama, H. and Nawa, Y. (1996). Kinetic study of eosinophil chemotactic factor production with reference to eosinophilia and granuloma formation in mice infected with Schistosoma japonicum. International Journal for Parasitology 26, 705–711.CrossRefGoogle ScholarPubMed
Owhashi, M., Matsumoto, J., Imase, A., Kirinoki, M., Kitikoon, V., Chigusa, Y. and Matsuda, H. (2005). Schistosoma mekongi: a prominent neutrophil chemotactic activity of egg antigen with reference to that of Schistosoma japonicum. Experimental Parasitology 110, 335–341.CrossRefGoogle ScholarPubMed
Sornmani, S. (1976). Current status of research on the biology of Mekong Schistosoma. Southeast Journal of Tropical Medicine and Public Health 7, 208–213.Google ScholarPubMed
Takahashi, K., Naito, M., Umeda, S. and Shultz, L. D. (1994). The role of macrophage colony-stimulating factor in hepatic glucan-induced granuloma formation in the osteopetrosis mutant mouse defective in the production of macrophage colony-stimulating factor. American Journal of Pathology 144, 1381–1392.Google ScholarPubMed
Urbani, C., Sinuon, M., Socheat, D., Pholsena, K., Strandgaard, H., Odermatt, P. and Hatz, C. (2002). Epidemiology and control of mekongi schistosomiasis. Acta Tropica 82, 157–168.CrossRefGoogle ScholarPubMed
Voge, M., Bruckner, D. and Bruce, J. I. (1978). Schistosoma mekongi sp. n. from man and animals, compared with four geographic strains of Schistosoma japonicum. Journal of Parasitology 64, 577–584.Google Scholar
Warren, K. S. and Berry, E. G. (1972). Induction of hepatosplenic disease by single pairs of the Philippine, Formosan, Japanese, and Chinese strains of Schistosoma japonicum. Journal of Infectious Diseases 126, 482–491.CrossRefGoogle ScholarPubMed
Warren, K. S., Boros, D. L., Hang, L. M. and Mahmoud, A. A. F. (1975). The Schistosoma japonicum egg granuloma. American Journal of Pathology 80, 279–289.Google ScholarPubMed
Warren, K. S., Grove, D. I. and Pelley, R. P. (1978). The Schistosoma japonicum egg granuloma II. Cellular composition, granuloma size, and immunologic concomitants. American Journal of Tropical Medicine and Hygiene 27, 271–275.CrossRefGoogle ScholarPubMed
Wittes, R., Maclean, D., Law, C. and Lough, J. O. (1984). Three cases of schistosomiasis mekongi from northern Laos. American Journal of Tropical Medicine and Hygiene 33, 1159–1165.CrossRefGoogle ScholarPubMed
Zilton, A. A. and Cheever, A. W. (1993). Characterization of the murine model of schistosomal hepatic periportal fibrosis (‘pipestem’ fibrosis). International Journal of Experimental Pathology 74, 195–202.Google Scholar