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Cross-resistance between sulphanilamide and paludrine (proguanil) in a strain of Plasmodium gallinaceum resistant to sulphanilamide

Published online by Cambridge University Press:  06 April 2009

Ann Bishop  and
Elspeth W. McConnachie
Ann Bishop
Affiliation:
From the Molteno Institute, University of Cambridge
Elspeth W. McConnachie
Affiliation:
From the Molteno Institute, University of Cambridge
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Extract

1. Resistance to sulphanilamide, of a low order, has been developed in a strain of Plasmodium gallinaceum by the treatment of patent infections with the drug.

2. The sulphanilamide-resistant strain was resistant to paludrine over the whole range of doses tolerated by the host; it also proved to be resistant to sulphathiazole, sulphapyridine and sulpha-diazine, though the degree of resistance shown was much slighter than to paludrine.

3. Resistance to paludrine developed in the sulphanilamide-resistant strain before any resistance to sulphadiazine could be detected.

Type
Research Article
Information
Parasitology , Volume 40 , Issue 1-2 , January 1950 , pp. 175 - 178
Copyright
Copyright © Cambridge University Press 1950

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References

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Bishop, A. & McConnachie, E. W. (1949). Pan (in. the Press).Google Scholar
Williamson, J., Bertram, D. S. & Lourie, E. H.Nature, Lond., 159, 885.CrossRefGoogle Scholar
Williamson, J. & Lourie, E. M. (1947). Ann. Ti Parasit. 41, 278.CrossRefGoogle Scholar