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The degradation rates of cytoplasmic tRNA, rRNA and mRNA in rats are elevated after infection with Nippostrongylus brasiliensis

Published online by Cambridge University Press:  01 February 1998

H. TOPP ,
R. DUDEN ,
U. STEPHAN  and
G. SCHÖCH
H. TOPP
Affiliation:
Forschungsinstitut für Kinderernährung, 44225 Dortmund, Germany
R. DUDEN
Affiliation:
Forschungsinstitut für Kinderernährung, 44225 Dortmund, Germany
U. STEPHAN
Affiliation:
Gesellschaft für Allergieforschung, 58455 Witten, Germany
G. SCHÖCH
Affiliation:
Forschungsinstitut für Kinderernährung, 44225 Dortmund, Germany
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Abstract

The effects of a parasitic infection with the nematode Nippostrongylus brasiliensis on the degradation rates of cytoplasmic tRNA, rRNA and mRNA in rats have been investigated by measuring the renal excretion rates of the modified RNA catabolites N6-threoninocarbonyladenosine, pseudouridine and 7-methylguanine. Between days 9 and 13 post-infection when the expulsion of N. brasiliensis is usually the most pronounced, the degradation rates of the different RNA classes were significantly higher than in the control rats (P<0·05) by, on average, +24% (tRNA), +34% (rRNA) and +26% (mRNA). We suspect that the elevated degradation rates of RNA are related to an increased production of reactive oxygen species by the host during the expulsion of N. brasiliensis.

Keywords

Nippostrongylus brasiliensisRNA degradationmodified RNA catabolitesnon-invasive methods
Type
Research Article
Information
Parasitology , Volume 116 , Issue 2 , February 1998 , pp. 197 - 201
Copyright
1998 Cambridge University Press

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