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Demodex density increases after adalimumab therapy in ankylosing spondylitis: a pilot study

Published online by Cambridge University Press:  18 April 2022

Xuegang Li Open the ORCID record for Xuegang Li [Opens in a new window] ,
Nelson Siu Kei Lam Open the ORCID record for Nelson Siu Kei Lam [Opens in a new window] ,
Li Yang ,
Anqi Liang ,
Xin Xin Long ,
Junli Guo  and
Shuping Zhong
Xuegang Li
Affiliation:
Department of Rheumatology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, People's Republic of China
Nelson Siu Kei Lam
Affiliation:
Faculty of Health and Sciences, The University of Adelaide, Adelaide, South Australia, Australia Department of Emergency, Lyell McEwin Hospital, Elizabeth, South Australia, Australia Department of Medicine, Monash University, Clayton, Victoria, Australia
Li Yang
Affiliation:
Department of Dermatology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, People's Republic of China
Anqi Liang
Affiliation:
Department of Rheumatology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, People's Republic of China
Xin Xin Long
Affiliation:
Faculty of Health and Sciences, The University of Adelaide, Adelaide, South Australia, Australia
Junli Guo*
Affiliation:
Department of Nephrology, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, People's Republic of China
Shuping Zhong*
Affiliation:
Department of Rheumatology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, People's Republic of China
*
Authors for correspondence: Junli Guo, E-mail: 77246356@qq.com; Shuping Zhong, E-mail: zhshup@mail.sysu.edu.cn
Authors for correspondence: Junli Guo, E-mail: 77246356@qq.com; Shuping Zhong, E-mail: zhshup@mail.sysu.edu.cn
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Abstract

Demodex infestation and density changes remain one of the main challenges in some clinical settings. Tumour necrosis factor-α (TNF-α) inhibitors have been recommended as a first-line treatment for ankylosing spondylitis (AS). However, there have been no studies investigating the impact of TNF-α inhibitor adalimumab on changes in the Demodex density in patients with AS. The aim of this study was to investigate Demodex density changes before and after adalimumab treatment and analyse the relationship between the Demodex density and clinical characteristics in AS. It was found that the Demodex density was positively correlated with age and C-reactive protein levels and the number of Demodex mites could increase after adalimumab treatment in AS.

Keywords

Adalimumabankylosing spondylitisDemodextumour necrosis factor-α
Type
Research Article
Information
Parasitology , Volume 149 , Issue 7 , June 2022 , pp. 940 - 943
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Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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Footnotes

*

These authors contributed equally to this work.

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