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The effect of oxyclozanide on Hymenolepis microstoma and H. diminuta

Published online by Cambridge University Press:  06 April 2009

C. A. Hopkins ,
P. M. Grant  and
Helen Stallard
C. A. Hopkins
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden, Glasgow
P. M. Grant
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden, Glasgow
Helen Stallard
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden, Glasgow
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Extract

The effect of oxyclozanide (2,2′-dihydroxy-3,3′,5,5′,6-pentachlorobenzanilide) on Hymenolepis microstoma in the bile duct of mice, and H. diminuta in the small intestine of mice and rats was measured. Oxyclozanide at doses as low as 4mg/kg removed 13-day-old H. diminuta and caused no obvious harmful effect to the rat host up to the maximum level (256 mg/kg) tested. Worms were displaced and degenerating within 1 h. Results in mice were more difficult to assess because of the immune response, but similar total amounts of oxyclozanide caused destrobilation and loss of 7-day-old H. diminuta. Oxyclozanide was less effective against 21-day-old H. microstoma attached in the bile duct. Approximately half the strobila was lost following dosing at 5 mg/kg and progressively greater amounts as the dose level was increased. At 50 mg/kg worm loss commenced but even at 150 mg/kg 25 % of worms survived. The time taken to regrow to the original adult size varied but was complete within 7–9 days at levels up to 25 mg/kg. Double dosing at 5-day intervals did not enhance the effect of a single dose. The apparent existence of a sensitivity gradient down the strobila in H. microstoma is discussed.

Type
Research Article
Information
Parasitology , Volume 66 , Issue 2 , April 1973 , pp. 355 - 365
Copyright
Copyright © Cambridge University Press 1973

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References

Broome, A. W., & Jones, W. G. M., (1966). A new drug for the treatment of Fascioliasis in sheep and cattle. Nature, London 210, 744–5.CrossRefGoogle ScholarPubMed
Harrow, W. T., (1969). Stilesia infestation in sheep. The Veterinary Record 84, 564.Google Scholar
Hopkins, C. A., (1970). Diurnal movement of Hymenolepis diminuta in the rat. Parasitology 60, 255–71.CrossRefGoogle ScholarPubMed
Hopkins, C. A., Subbamanian, G., & Stallard, H., (1972a). The development of Hymenolepis diminuta in primary and secondary infections in mice. Parasitology 64, 401–12.CrossRefGoogle ScholarPubMed
Hopkins, C. A., Subbamanian, G., & Stallard, H., (1972b). The effect of immunosuppressants on the development of Hymenolepis diminuta in mice. Parasitology 65, 111–20.CrossRefGoogle ScholarPubMed
Macphekson, M., (1958). Failure of the excretory ducts of a tapeworm (Hymenolepis diminuta) to transport absorbed substances from one portion of the worm to another. Journal of Parasitology 44, 438.CrossRefGoogle Scholar
Moss, G. D., (1971). The nature of the immune response of the mouse to the bile duct cestode, Hymenolepis microstoma. Parasitology 62, 285–94.CrossRefGoogle Scholar
Turton, J. A., (1971). Distribution and growth of Hymenolepis diminuta in the rat, hamster and mouse. Zeitschrift für Parasitenkunde 37, 315–29.CrossRefGoogle ScholarPubMed
Wallley, J. K., (1966). Oxyclozanide (3,3′,5,5′,6-pentachloro-2,2′-dihydroxybenzanilide ‘Zanil’) in the treatment of the liver fluke Fasciola hepatica in sheep and cattle. The Veterinary Record 78, 267–76.CrossRefGoogle Scholar