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The effect of Plasmodium falciparum exo-antigens on the morphology of uninfected erythrocytes

Published online by Cambridge University Press:  06 April 2009

D. G. Read ,
G. R. Bushell  and
C. Kidson
D. G. Read
Affiliation:
Queensland Institute of Medical Research, Bramston Terrace, Herston, Queensland 4006, Australia
G. R. Bushell
Affiliation:
Queensland Institute of Medical Research, Bramston Terrace, Herston, Queensland 4006, Australia
C. Kidson
Affiliation:
Queensland Institute of Medical Research, Bramston Terrace, Herston, Queensland 4006, Australia
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Summary

It was observed that uninfected red cells resuspended in supernatant from Plasmodium falciparum cultures, then examined between a glass slide and cover-slip, assumed varying morphologies. A series of experiments suggested that P. falciparum releases molecules which cause red cells to become stomatocytic (cupped). These molecules, some of which are heat- stable, have an apparent molecular weight < 12 kDa, are released at or about schizogony, and do not bind tightly to erythrocytes.

Keywords

malariaexo-antigenserythrocytemorphology
Type
Research Article
Information
Parasitology , Volume 100 , Issue 2 , April 1990 , pp. 185 - 190
Copyright
Copyright © Cambridge University Press 1990

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