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Experimental evidence of genetic determinism in high susceptibility to intestinal pinworm infection in mice: a hybrid zone model

Published online by Cambridge University Press:  06 April 2009

C. Moulia ,
N. Le Brun ,
J. Dallas ,
A. Orth  and
F. Renaud
C. Moulia
Affiliation:
Laboratoire de Parasitologic Comparée (URA 698, CNRS), Université de Montpellier II, Place E. Bataillon, 34 095 Montepellier cédex 5, France
N. Le Brun
Affiliation:
Laboratoire de Parasitologic Comparée (URA 698, CNRS), Université de Montpellier II, Place E. Bataillon, 34 095 Montepellier cédex 5, France
J. Dallas
Affiliation:
Equipe ‘Génome et Populations’ (URA 1493, CNRS), Université de Montpellier II, Place E. Bataillon, 34 095 Montepellier cédex 5, France
A. Orth
Affiliation:
Equipe ‘Génome et Populations’ (URA 1493, CNRS), Université de Montpellier II, Place E. Bataillon, 34 095 Montepellier cédex 5, France
F. Renaud
Affiliation:
Laboratoire de Parasitologic Comparée (URA 698, CNRS), Université de Montpellier II, Place E. Bataillon, 34 095 Montepellier cédex 5, France
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Summary

In the hybrid zone of the two mouse subspecies Mus musculus musculus and Mus musculus domesticus, mice with hybrid genotypes harbour, on the average, more helminth parasites (cestodes and nematodes) than mice of the two parental taxa. In order to determine the roles played by genetic parameters in this phenomenon, mice with recombined and parental genotypes were experimentally infected with the intestinal pinworm Aspiculuris tetraptera, a natural parasite of the house mouse. The results showed that the high susceptibility of the hybrid zone mice is genetically determined. In addition, this study shows the occurrence of variability among resistant parental populations.

Keywords

hybrid zonemiceintestinal pinwormsAspiculuris tetrapterasusceptibilitygenetic determinism.
Type
Research Article
Information
Parasitology , Volume 106 , Issue 4 , May 1993 , pp. 387 - 393
Copyright
Copyright © Cambridge University Press 1993

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