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Experimental infection with Schistosoma mansoni isolated from the wild rodent Holochilus sciureus shows a low parasite burden but induces high schistosomiasis severity in BALB/c mice

Published online by Cambridge University Press:  01 June 2022

Guilherme Silva Miranda Open the ORCID record for Guilherme Silva Miranda [Opens in a new window] ,
João Gustavo Mendes Rodrigues ,
Michelle Carvalho de Rezende ,
Samira Diniz Resende ,
Genil Mororó Araújo Camelo ,
Jeferson Kelvin Alves de Oliveira Silva ,
Laura Maggi ,
Vanessa Fernandes Rodrigues ,
Vinícius Gustavo de Oliveira  and
Deborah Aparecida Negrão-Corrêa Open the ORCID record for Deborah Aparecida Negrão-Corrêa [Opens in a new window]
Guilherme Silva Miranda
Affiliation:
Department of Parasitology, Federal University of Minas Gerais, Institute of Biological Sciences, Belo Horizonte, Brazil Department of Biology, Federal Institute of Education, Science and Technology of Maranhão, São Raimundo das Mangabeiras, Brazil
João Gustavo Mendes Rodrigues
Affiliation:
Department of Parasitology, Federal University of Minas Gerais, Institute of Biological Sciences, Belo Horizonte, Brazil
Michelle Carvalho de Rezende
Affiliation:
Department of Parasitology, Federal University of Minas Gerais, Institute of Biological Sciences, Belo Horizonte, Brazil
Samira Diniz Resende
Affiliation:
Department of Parasitology, Federal University of Minas Gerais, Institute of Biological Sciences, Belo Horizonte, Brazil
Genil Mororó Araújo Camelo
Affiliation:
Department of Parasitology, Federal University of Minas Gerais, Institute of Biological Sciences, Belo Horizonte, Brazil
Jeferson Kelvin Alves de Oliveira Silva
Affiliation:
Department of Parasitology, Federal University of Minas Gerais, Institute of Biological Sciences, Belo Horizonte, Brazil
Laura Maggi
Affiliation:
Department of Parasitology, Federal University of Minas Gerais, Institute of Biological Sciences, Belo Horizonte, Brazil
Vanessa Fernandes Rodrigues
Affiliation:
Department of Parasitology, Federal University of Minas Gerais, Institute of Biological Sciences, Belo Horizonte, Brazil
Vinícius Gustavo de Oliveira
Affiliation:
Department of Parasitology, Federal University of Minas Gerais, Institute of Biological Sciences, Belo Horizonte, Brazil
Deborah Aparecida Negrão-Corrêa*
Affiliation:
Department of Parasitology, Federal University of Minas Gerais, Institute of Biological Sciences, Belo Horizonte, Brazil
*
Author for correspondence: Deborah Negrão-Corrêa, E-mail: denegrao@icb.ufmg.br
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Abstract

Wild mammals, especially rodents, can participate in the life cycle of Schistosoma mansoni; however, the impact of these parasite strains on the severity of schistosomiasis remains unclear. The aim of this study was to comparatively evaluate the parasitological and immunopathological alterations induced by an S. mansoni strain isolated from the wild rodent Holochilus sciureus (HS strain) and a parasite strain isolated from a human (LE strain) in experimentally infected mice. Male BALB/c mice were subcutaneously infected with 50 cercariae/mouse of either the HS or the LE strain and were evaluated for 12 weeks. In the experimental groups, the parasite burden was estimated by worm and egg (feces and tissues) count, and immunopathological alterations were evaluated in the liver and intestines. Compared to experimental infection with the LE parasite strain, HS-infected mice showed reduced number of parasite worms but higher fecundity rate, significant reduction in IL-5, IL-10 and IL-13 concentrations, lower EPO-activity in liver homogenate and higher concentrations of TNF-α, IFN-γ, IL-12 and IL-17 in the small intestine homogenate. Moreover, HS infection resulted in higher concentrations of NO end-products in both the liver and intestine, suggesting a predominance of the Th1/Th17 immune response. HS-infected mice also showed higher plasma transaminase levels, formed larger granulomas, and had a higher mortality rate in comparison with LE-infected mice. Data indicate that BALB/c mice infected with the HS strain of S. mansoni showed reduced susceptibility to the parasite but stronger tissue inflammation and high disease severity.

Keywords

Holochilus sciureusimmune responseparasite burdenwild strain of Schistosoma mansonischistosomiasis severitySchistosoma-induced granulomatous inflammation
Type
Research Article
Information
Parasitology , Volume 149 , Issue 11 , September 2022 , pp. 1381 - 1396
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Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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