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Experiments on the Action of Emetine in Cultures of Entamoeba Coli.

Published online by Cambridge University Press:  06 April 2009

Ann Bishop
Ann Bishop
Affiliation:
National Institute for Medical Research, London, N.W.3.
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Extract

1. Two pure strains of Entamoeba coli, differing in their accompanying bacterial flora and experimental history, but identical morphologically, have been tested with emetine hydrochloride in vitro.

2. In a buffered and wholly liquid medium, with a pH varying between 6·8 and 7·2, emetine hydrochloride was found to be toxic to E. coli in dilutions between 1 : 300,000 and 1 : 600,000, the toxicity increasing with the alkalinity of the medium.

3. It is therefore concluded that emetine is about 16 times as toxic in vitro to E. histolytica as it is to E. coli.

Type
Research Article
Information
Parasitology , Volume 21 , Issue 4 , December 1929 , pp. 481 - 486
Copyright
Copyright © Cambridge University Press 1929

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References

REFERENCES

Bishop, A. (1927). The effect of increased and decreased oxygen pressure upon the intestinal protozoa of Macacus rhesus. Parasitology, 19, 401.CrossRefGoogle Scholar
Dobell, C. and Bishop, A. (1929). Researches on the intestinal protozoa of monkeys and man. III. The action of emetine on natural amoebic infections in macaques. Parasitology, (in the press).CrossRefGoogle Scholar
Dobell, C. and Laidlaw, P. P. (1926). The action of ipecacuanha alkaloids on Entamoeba histolytica and some other entozoic amoebae in culture. Parasitology, 18, 206.CrossRefGoogle Scholar
Dobell, C. and Laidlaw, P. P. (1926 a). On the cultivation of Entamoeba histolytica and some other entozoic amoeba. Parasitology, 283.CrossRefGoogle Scholar
Laidlaw, P. P., Dobell, C. and Bishop, A. (1928). Further experiments on the action of emetine in cultures of Entamoeba histolytica. Parasitology, 20, 207.CrossRefGoogle Scholar