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Genetic control of liability to infection with Nematospiroides dubius in mice: selection of refractory and liable populations of mice

Published online by Cambridge University Press:  06 April 2009

P. J. Brindley  and
C. Dobson
P. J. Brindley
Affiliation:
Department of Parasitology, University of Queensland, St Lucia 4067, Australia
C. Dobson
Affiliation:
Department of Parasitology, University of Queensland, St Lucia 4067, Australia
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Summary

Quackenbush strain and wild Mus musculus were assayed for their liability to primary infection with 100 LaNematospiroides dubius using an experimentally derived selection index. Refractory and liable colonies of mice were established over 5 generations. Liability to N. dubius infection was found likely to be controlled by several genes; the heritability (h2) of this trait was estimated at 0·45. Positive linear correlation was found between the number of parasite eggs voided and the number of adult N. dubius recovered, negative correlation between the pre-patent period of infection in days and the number of parasite eggs voided and positive correlation in 2 of 5 generations between live mouse body weight and the number of adult N. dubius recovered. Further, positive correlation was found between the liability of female mice to N. dubius and their progeny litter size number. The genetic mechanisms controlling the liability trait and the possible evolutionary significance of these results are discussed.

Type
Research Article
Information
Parasitology , Volume 83 , Issue 1 , August 1981 , pp. 51 - 65
Copyright
Copyright © Cambridge University Press 1981

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