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Genetic susceptibility to malaria and other infectious diseases: from the MHC to the whole genome

Published online by Cambridge University Press:  06 April 2009

A. V. S. Hill
A. V. S. Hill
Affiliation:
Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Windmill Road, Oxford OX3 7BN, U.K.
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Extract

There is substantial evidence that host genetic factors play a major role in determining the outcome of infection with many pathogens. Detailed analysis of malaria has identified twelve genes that affect susceptibility in various human populations. However, less attention has been paid to other major infectious diseases where twin studies have identified an important host genetic component to susceptibility. Recent progress in the analysis of the human genome offers exciting prospects for the mapping and identification of new susceptibility and resistance genes for common infectious diseases. Screening of the whole genome in affected sibling pair studies is now feasible by employing highly informative microsatellite markers. In addition, many polymorphic candidate genes have become available for analysis in case-control studies. It is proposed that these new genetic tools offer a powerful approach to the epidemiological analysis of many infectious diseases in humans and supersede traditional genetic approaches to identifying susceptibility genes in mouse models. Progress in characterizing the role of major histocompatibility genes in susceptibility to malaria and other infectious diseases is reviewed before outlining the methodologies for and progress in identifying non-MHC susceptibility genes.

Keywords

Human leucocyte antigenmalariacandidate genelinkage mappingtumour necrosis factor.
Type
Research Article
Information
Parasitology , Volume 112 , Supplement S1: Symposia of the British Society for Parasitology Volume 33:Genetics of host and parasite: implications for immunity, epidemiology and evolution , March 1996 , pp. S75 - S84
Copyright
Copyright © Cambridge University Press 1996

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