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The host–parasite relationships in normal and protein-malnourished cotton rats infected with Litomosoides carinii (Nematoda: Filarioidea)

Published online by Cambridge University Press:  06 April 2009

D. M. Storey
D. M. Storey
Affiliation:
Department of Biology, University of Salford, Salford M5 4WT
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Extract

A total of 120 young cotton rats were fed ad libitum for 10 weeks on either synthetic diets containing 2·5, 5, 10 or 15% casein or on a stock breeding diet containing 20% crude protein. Half of the animals in each group were infected with the filarial nematode Litomosoides carinii and the food intake and body weight of each animal was measured. There was a trend towards increased food consumption in protein-deficient cotton rats and this was increased further in infected animals; however, differences between groups were not significant. Low protein diets reduced the rate of growth of uninfected and infected cotton rats; filarial infection intensified these adverse effects of under-nutrition and increased the number of rats which died in the lowest protein group. Protein deficiency had little effect on the number of L. carinii which developed, although fewer parasites became established in cotton rats fed on a 2·5% diet than in those fed on a 10% diet. Parasites developing in protein-deficient animals were shorter than those developing in well-fed ones and embryo-genesis was retarded in female worms from protein-deficient animals. The onset of patency was retarded in protein-deficient animals and the microfilaraemia which developed subsequently was lower up to 120 days post-infection.

Type
Research Article
Information
Parasitology , Volume 85 , Issue 3 , December 1982 , pp. 543 - 558
Copyright
Copyright © Cambridge University Press 1982

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References

Akpom, C. A. & Warren, K. S. (1975). Calorie and protein malnutrition in chronic murine schistosomiasis mansoni: Effect on the parasite and the host. Journal of Infectious Diseases 132, 6–14.CrossRefGoogle ScholarPubMed
Al-Baldawi, F. A. K. (1976). Cotton rat filariasis: immunoglobulin in the early stages of infection in cotton rats with and without protein deficiency. Ph.D. thesis, University of Salford.Google Scholar
Al-Rabii, H. A. & Platt, B. S. (1964). Effect of chronic roundworm infection (Toxocara canis) on protein metabolism in dogs fed diets of different protein value. Proceedings of the Nutrition Society 23, 4.Google Scholar
Bertram, D. S., Unsworth, K. & Gordon, R. M. (1946). The biology and maintenance of Liponyssus bacoti (Hirst, 1913), and an investigation into its role as a vector of Litomosoides carinii to cotton rajts and white rats, together with some observations on the infection in the white rat. Annals of Tropical Medicine and Parasitology 40, 228–54.Google Scholar
Chandra, R. K. (1980). Immunology of Nutritional Disorders. London: Edward Arnold.Google Scholar
Crompton, D. W. T. (1981). Parasitic infection and host nutrition. Third European Multicolloquium of Parasitology, Parasitology 82, Part 4, 31–32.Google Scholar
Crompton, D. W. T., Walters, D. E. & Arnold, S. (1981). Changes in the food intake and body weight of protein malnourished rats infected with Nippostrongylus brasiliensis (Nematoda). Parasitology 82, 23–38.CrossRefGoogle ScholarPubMed
De Meillon, B. & Paterson, S. (1958). Experimental bilharziasis in animals. VII. Effect of a low protein diet on bilharziasis in white mice. South African Medical Journal 32, 1086–8.Google ScholarPubMed
De Witt, W. B. (1957). Experimental schistosomiasis mansoni in mice maintained on nutritionally deficient diets: I and II. Journal of Parasitology 43, 119–28.CrossRefGoogle Scholar
De Witt, W. B. (1957). Experimental schistosomiasis mansoni in mice maintained on nutritionally deficient diets: I and II. Journal of Parasitology 43, 129–35.CrossRefGoogle Scholar
Fadl, A. M. (1971). The influence of dietary protein level upon the response of mice infected with Schistosoma mansoni to treatment with Niridazole (Ambilhar). Journal of Helminthology XLV, 117–22.CrossRefGoogle ScholarPubMed
Howells, R. E. & Chen, S. N. (1979). The uptake in vitro of dyes, monosaccharides and amino-acids by the filarial worm Brugia pahangi. Parasitology 78, 343–54.Google Scholar
Howells, R. E. & Chen, S. N. (1981). Brugia pahangi: Feeding and nutrient uptake in vitro and in vivo. Experimental Parasitology 51, 42–58.CrossRefGoogle ScholarPubMed
Jayapragasam, M., Bagai, R. C. & Subrahmanyam, D. (1977). The effect of malnutrition and filarial infection in albino rats. Indian Journal of Medical Research 65, 346–52.Google ScholarPubMed
Kershaw, W. E. (1949). Observations on Litomosoides carinii. III. The first stage larva in the peripheral circulation. Annals of Tropical Medicine and Parasitology 43, 238–60.CrossRefGoogle Scholar
Kershaw, W. E. & Storey, D. M. (1976). Host–parasite relations in cotton rat filariasis. I. The quantitative transmission and subsequent development of Litomosoides carinii infections in cotton rats and other laboratory animals. Annals of Tropical Medicine and Parasitology 70, 303–12.CrossRefGoogle ScholarPubMed
Knauft, R. F. & Warren, K. S. (1969). The effect of calorie and protein malnutrition on both the parasite and the host in acute murine Schistosomiasis mansoni. Journal of Infectious Diseases 120, 560–75.CrossRefGoogle Scholar
Latham, M. C. (1975). Nutrition and infection in national development. Science 188, 561–5.CrossRefGoogle ScholarPubMed
McGraith, B. G., Kershaw, W. E. & Dagnall, D. (1961). Techniques in Tropical Parasitology. Edinburgh and London: Oliver and Boyd.Google Scholar
Miller, D. S. & Payne, P. R. (1961). Problems in the prediction of protein values of diets: The influence of protein concentration. British Journal of Nutrition 15, 11–19.CrossRefGoogle ScholarPubMed
Orraca-Tetteh, F. (1964). Protein values of Ghanaian diets and the effect on protein metabolism of infestation of the rat with Nippostrongylus muris. Ph.D. thesis, University of London.Google Scholar
Pillai, C. R., Gupta, J. P. & Ramachandran, M. (1976). The effect of L. carinii infection in albino rats on body weight, food intake and degree of parasitemia. Journal of Communicable Diseases 8, 320–2.Google Scholar
Platt, B. S. & Heard, C. R. C. (1965). Contributions of infections to protein-calorie deficiency. Transactions of the Royal Society of Tropical Medicine and Hygiene 59, 571–81.CrossRefGoogle ScholarPubMed
Prasad, R., Rao, Y. V. B. G., Mehta, K. & Subrahmanyam, D. (1980). Effect of thiamine deficiency on filarial infection in albino rats with Litomosoides carinii. International Journal for Parasitology 10, 93–6.CrossRefGoogle ScholarPubMed
Prasad, R., Rao, Y. V. B. G., Sindhu, R. K. & Subbahmanyam, D. (1980). The effect of pyridoxine deficiency on the infection of albino rats with Litomosoides carinii. Transactions of the Royal Society for Tropical Medicine and Hygiene 74, 459–62.CrossRefGoogle ScholarPubMed
Scott, J. A., MacDonald, E. M. & Terman, B. (1951). A description of the life-cycle of the filarial worm Litomosoides carinii. Journal of Parasitology 37, 425–32.CrossRefGoogle ScholarPubMed
Scrimshaw, N. S., Taylor, C. E. & Gordon, J. E. (1968). Interactions of Nutrition and Infection. Geneva: World Health Organization, Monograph Series, No. 57.Google ScholarPubMed
Storey, D. M. (1981). Parasitic infection and host nutrition. Third European Multicolloquium of Parasitology, Parasitology 82, Part 4, 35–6.Google Scholar
Storey, D. M. (1982). Vitamin A deficiency and the development of Litomosoides carinii (Nematoda, Filarioidea) in cotton rats. Zeitschrift für Parasitenkunde (in the Press).CrossRefGoogle Scholar
Storey, D. M., Wells, P. D. & Kershaw, W. E. (1971). Protein deficiency and cotton rat filariasis. Transactions of the Royal Society of Tropical Medicine and Hygiene 65, 21.Google ScholarPubMed