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Immunity to malaria in an era of declining malaria transmission

Published online by Cambridge University Press:  07 January 2016

FREYA J. I. FOWKES ,
PHILIPPE BOEUF  and
JAMES G. BEESON
FREYA J. I. FOWKES*
Affiliation:
Burnet Institute, Melbourne, Australia Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia Department of Epidemiologyand Preventive Medicine, Monash University, Melbourne, Australia Department of Infectious Diseases, Monash University, Melbourne, Australia
PHILIPPE BOEUF
Affiliation:
Burnet Institute, Melbourne, Australia Department of Medicine, The University of Melbourne, Melbourne, Australia Victorian Infectious Diseases Service, Royal Melbourne Hospital, Melbourne, Australia
JAMES G. BEESON
Affiliation:
Burnet Institute, Melbourne, Australia Department of Medicine, The University of Melbourne, Melbourne, Australia Department of Microbiology, Monash University, Melbourne, Australia
*
*Corresponding author. Burnet Institute, 85 Commercial Road, Melbourne, VIC 3004, Australia. E-mail: fowkes@burnet.edu.au
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Summary

With increasing malaria control and goals of malaria elimination, many endemic areas are transitioning from high-to-low-to-no malaria transmission. Reductions in transmission will impact on the development of naturally acquired immunity to malaria, which develops after repeated exposure to Plasmodium spp. However, it is currently unclear how declining transmission and malaria exposure will affect the development and maintenance of naturally acquired immunity. Here we review the key processes which underpin this knowledge; the amount of Plasmodium spp. exposure required to generate effective immune responses, the longevity of antibody responses and the ability to mount an effective response upon re-exposure through memory responses. Lastly we identify research priorities which will increase our understanding of how changing transmission will impact on malarial immunity.

Keywords

Malariafalciparumvivaximmunityantibodiestransmission
Type
Special Issue Article
Information
Parasitology , Volume 143 , Issue 2: Naturally Acquired Immunity to Malaria , February 2016 , pp. 139 - 153
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Copyright
Copyright © Cambridge University Press 2016 

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References

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