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In vitro and in vivo trematode models for chemotherapeutic studies

Published online by Cambridge University Press:  07 December 2009

J. KEISER
J. KEISER*
Affiliation:
Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, CH-4002Basel, Switzerland
*
*Corresponding author: Tel: +41 61 284-8218; Fax: +41 61 284-8105. E-mail: jennifer.keiser@unibas.ch
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Summary

Schistosomiasis and food-borne trematodiases are chronic parasitic diseases affecting millions of people mostly in the developing world. Additional drugs should be developed as only few drugs are available for treatment and drug resistance might emerge. In vitro and in vivo whole parasite screens represent essential components of the trematodicidal drug discovery cascade. This review describes the current state-of-the-art of in vitro and in vivo screening systems of the blood fluke Schistosoma mansoni, the liver fluke Fasciola hepatica and the intestinal fluke Echinostoma caproni. Examples of in vitro and in vivo evaluation of compounds for activity are presented. To boost the discovery pipeline for these diseases there is a need to develop validated, robust high-throughput in vitro systems with simple readouts.

Keywords

Schistosoma mansoniFasciola hepaticaEchinostoma caproniin vitroin vivodrug discoverychemotherapy
Type
Research Article
Information
Parasitology , Volume 137 , Special Issue 3: Development and applications of cestode and trematode laboratory models , March 2010 , pp. 589 - 603
Copyright
Copyright © Cambridge University Press 2009

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