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Iron acquisition in Leishmania and its crucial role in infection

Published online by Cambridge University Press:  25 May 2016

QINWANG NIU ,
SHIHONG LI ,
DALI CHEN ,
QIWEI CHEN  and
JIANPING CHEN
QINWANG NIU
Affiliation:
Department of Parasitology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China Sichuan Engineering Technical College, Deyang, Sichuan 618000, China
SHIHONG LI
Affiliation:
The Third People's Hospital of Chengdu, Chengdu, Sichuan 610031, China
DALI CHEN
Affiliation:
Department of Parasitology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China
QIWEI CHEN
Affiliation:
Department of Parasitology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China
JIANPING CHEN*
Affiliation:
Department of Parasitology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China
*
*Corresponding author: Department of Parasitology, West China School of Preclinical and Forensic Medicine, Sichuan University, NO.17, Third part Ren Min Road, Chengdu, Sichuan, China. E-mail: jpchen1965@163.com
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Summary

Iron is an essential cofactor for many basic metabolic pathways in pathogenic microbes and their hosts. It is also dangerous as it can catalyse the production of reactive free radicals. This dual character makes the host can either limit iron availability to invading microbes or exploit iron to induce toxicity to pathogens. Successful pathogens, including Leishmania species, must possess mechanisms to circumvent host's iron limitation and iron-induced toxicity in order to survive. In this review, we discuss the regulation of iron metabolism in the setting of infection and delineate the iron acquisition strategies used by Leishmania parasites and their subversions to host iron metabolism to overcome host's iron-related defences.

Keywords

ironLeishmaniairon acquisitionsubversion
Type
Review Article
Information
Parasitology , Volume 143 , Issue 11 , September 2016 , pp. 1347 - 1357
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Copyright
Copyright © Cambridge University Press 2016 

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