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Iron overload increases hepatic development of Plasmodium yoelii in mice

Published online by Cambridge University Press:  26 March 2010

J. Goma ,
L. Rénia ,
F. Miltgen  and
D. Mazier
J. Goma
Affiliation:
U313 Inserm and Département de Parasitologie, Groupe Hospitalier Pitié-Salpêtrière, 91 Bld de l'Hôpital, 75013 Paris, France
L. Rénia
Affiliation:
U313 Inserm and Département de Parasitologie, Groupe Hospitalier Pitié-Salpêtrière, 91 Bld de l'Hôpital, 75013 Paris, France
F. Miltgen
Affiliation:
Muséum d'Histoire Naturelle, 75006 Paris, France
D. Mazier
Affiliation:
U313 Inserm and Département de Parasitologie, Groupe Hospitalier Pitié-Salpêtrière, 91 Bld de l'Hôpital, 75013 Paris, France
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Summary

Iron overload in BALB/c mice by treatment with ferric ammonium citrate promotes the hepatic development of Plasmodium yoelii in vivo and in vitro. This was the result of increased penetration of the parasite into hepatocytes since no effect was observed on parasite transformation or maturation. These results could explain why in endemic regions iron supplementation led, in certain studies, to an increase in clinical episodes of malaria and in the prevalence of malaria infection.

Keywords

malariaironliver
Type
Research Article
Information
Parasitology , Volume 112 , Issue 2 , February 1996 , pp. 165 - 168
Copyright
Copyright © Cambridge University Press 1996

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