Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-27T12:24:22.620Z Has data issue: false hasContentIssue false
  • English
  • Français

Kinetics of classes and sub-classes of total immunoglobulins and specific antibodies to Schistosoma mansoni during murine infection

Published online by Cambridge University Press:  06 April 2009

D. Bout ,
R. Rousseaux ,
Y. Carlier  and
A. Capron
D. Bout
Affiliation:
Service d'Immunologie et de Biologie Parasitaire des U.E.R. de Médecine et de Pharmacie, et de l'Institut Pasteur de Lille
R. Rousseaux
Affiliation:
Service d'Immunologie et de Biologie Parasitaire des U.E.R. de Médecine et de Pharmacie, et de l'Institut Pasteur de Lille
Y. Carlier
Affiliation:
Service d'Immunologie et de Biologie Parasitaire des U.E.R. de Médecine et de Pharmacie, et de l'Institut Pasteur de Lille
A. Capron
Affiliation:
Service d'Immunologie et de Biologie Parasitaire des U.E.R. de Médecine et de Pharmacie, et de l'Institut Pasteur de Lille
Get access Rights & Permissions [Opens in a new window]

Summary

During the course of Schistosoma mansoni murine infection there is a dramatic increase of some immunoglobulins and S. mansoni-specinc antibodies. The most substantial response is initiated after 40 days of infection and results in a prolonged increase of total IgG1; IgM and IgA. The maximum increase is respectively 26, 14 and 3-fold the basic immunoglobulin level in control mice. Some anti-S. mansoni classes and sub-classes were studied by an original radio-immunoadsorbent test. Anti-S. mansoni IgG1 and IgM antibodies appear and increase at the same time as that of total IgG1 and IgM. Anti-S. mansoni IgA antibodies appear later (80th day) and correspond to a second peak of total IgA.

Type
Research Article
Information
Parasitology , Volume 80 , Issue 2 , April 1980 , pp. 247 - 256
Copyright
Copyright © Cambridge University Press 1980

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Axen, R., Porath, J. & Ernback, S. (1967). Chemical coupling of peptides and proteins to polysaccharides by means of cyanogen halides. Nature, London 214, 1302–4.CrossRefGoogle ScholarPubMed
Bout, D., Santoro, F., Carlier, Y., Bina, J. C. & Capron, A. (1977). Circulating immune complexes in schistosomiasis. Immunology 33, 17–22.Google ScholarPubMed
Camus, D., Dessaint, J. P., Fischer, E. & Capron, A. (1978). Immunomodulating substances from parasites. Their role in the regulation of the immune response In The Pharmacology of Immunoregulation (ed Werner, G. H. and Floc'h, F.), pp. 253–265. New York and London: Academic Press.Google Scholar
Capron, A., Biguet, J., Vernes, A. & Afchain, D. (1968). Structure antigénique des helminthes. Aspects immunologiques des relations hôte-parasite. Pathologie-Biologie 16, 121–138.Google Scholar
Capron, A., Wattre, P., Capron, M. & Lefebvre, M. N. (1972). Le diagnostic moderne des parasitoses humaines. La Revue du Praticien 22, 3661–74.Google Scholar
Capron, M., Capron, A., Torpier, G., Bazin, H., Bout, D. & Joseph, M. (1978). Eosinophil-dependent cytotoxicity in rat schistosomiasis. Involvement of IgG20 antibody and role of mast cells. European Journal of Immunology 8, 127–33.CrossRefGoogle Scholar
Cheever, A. W. & Anderson, L. A. (1971). The rate of destruction of S. mansoni eggs in the tissues of mice. American Journal of Tropical Medicine and Hygiene 20, 62–8.CrossRefGoogle Scholar
Cohen, S. (1974). The immune response to parasite. In Parasites in the Immunized Host: Mechanism of Survival. CIBA Fdn Symp. 25, pp. 6–7. Amsterdam: Associated Scientific Publishers.Google Scholar
Coles, G. C. (1973). The metabolism of schistosomes: a review. International Journal of Biochemistry 4, 319–37.CrossRefGoogle Scholar
Colley, D. G. (1975). Immune responses to a soluble schistosomal egg antigen preparation during chronic primary infection with Schistosoma mansoni. Journal of Immunology 115, 150–6.CrossRefGoogle ScholarPubMed
Colley, D. G., Katz, S. P. & Wikel, S. K. (1974). Schistosomiasis: an experimental model for the study of immunopathologic mechanism which involve eosinophils. Advances in Biosciences 12, 653–65.Google Scholar
Coudert, J., Garin, J. P., Ambroise-Thomas, P. & Pottier, M. A. (1967). Premiers résultats à propos du diagnostic sérologique de la bilharziose par immunofluorescence sur coupes à congélation de S. mansoni. Annales de Parasitologie Humaine et Comparée 42, 483–92.CrossRefGoogle Scholar
Crandall, C. A. & Crandall, R. B. (1971). Ascaris suum: immunoglobulin responses in mice. Experimental Parasitology 30, 426–37.CrossRefGoogle ScholarPubMed
Crandall, R. B. & Crandall, C. A. (1972). Trichinella spiralis: immunologic responses to infection in mice. Experimental Parasitology 31, 378–98.CrossRefGoogle ScholarPubMed
Evans, A. S. & Stirewalt, M. A. (1957). Serologic reactions in Schistosoma mansoni infections. III — Ionographic fractionation of sera of mice with progressive disease. Experimental Parasitology 6, 8–17.CrossRefGoogle ScholarPubMed
Fischer-Le Boubennec, E. (1978). Altérations de la réponse immune dans la schistosomiase expérimentale de la souris à S. mansoni Ph.D. thesis., University of Lille.Google Scholar
Freeman, T., Smithers, S. R., Targett, G. A. T. & Walker, P. J. (1970). Specificity of immunoglobulin G in rhesus monkeys infected with Schistosoma mansoni, Plasmodium knowlesi and Trypanosoma brucei. The Journal of Infectious Diseases 121, 401–6.CrossRefGoogle ScholarPubMed
Hunter, W. M. & Greenwood, F. C. (1962). Preparation of iodine-131 labelled human growth hormone of high specific activity. Nature, London 194, 495–6.CrossRefGoogle ScholarPubMed
Jaimes, S. & Von Lichtenberg, F. (1965). Host response to eggs of S. mansoni. IV — Fluorescent antibody titres in mice infected with normal cercariae, gammaradiated cercariae and with purified eggs. American Journal of Tropical Medicine and Hygiene 14, 727–35.CrossRefGoogle Scholar
Jarret, E. & Bazin, H. (1974). Elevation of total serum IgE in rats following helminth parasite infection. Nature, London 251, 613–14.CrossRefGoogle Scholar
Jarret, E. & Ferguson, A. (1974). Effect of T cell depletion on the potentiated reagin response. Nature, London 250, 420–2.CrossRefGoogle Scholar
Kassis, A. I., Aikawa, M. & Mahmoud, A. F. (1979). Mouse antibody-dependent eosinophil and macrophage adherence and damage to schistosomula of Schistosoma mansoni. Journal of Immunology 122, 398–405.CrossRefGoogle ScholarPubMed
Nussenzweig, R. S., Merryman, C. & Benacerraf, B. (1964). Electrophoretic separation and properties of mouse anti-hapten antibodies involved in passive cutaneous anaphylaxis and passive hemolysis. Journal of Experimental Medicine 120, 315–28.CrossRefGoogle Scholar
Olivier, L. & Schneidermann, M. (1953). Acquired resistance to Schistosoma mansoni in laboratory animals. American Journal of Tropical Medicine and Hygiene 2, 298–306.CrossRefGoogle ScholarPubMed
Rousseaux-Prévost, R., Bazin, H. & Capron, A. (1977). IgE in experimental schistosomiasis. 1 — Serum IgE levels after infection by Schistosoma mansoni in various strains of rats. Immunology 33, 501–5.Google Scholar
Rousseaux-Prévost, R. (1977). Etude de la réponse IgE dans la schistosomiase expérimentale du rat Ph.D. thesis., University of Lille.Google Scholar
Sher, A., Mackenzie, P. & Smithers, S. R. (1974). Decreased recovery of invading parasites from the lungs as a parameter of acquired immunity to schistosomiasis in the mouse. Journal of Infectious Diseases 130, 626–33.CrossRefGoogle ScholarPubMed
Sher, A., McIntyre, S. & Von Lichtenberg, F. (1977). Schistosoma mansoni: kinetics and class specificity of hypergammaglobulinemia induced during murine infection. Experimental Parasitology 41, 415–22.CrossRefGoogle ScholarPubMed
Sher, A., Smithers, S. R. & Mackenzie, P. (1975). Passive transfer of acquired resistance to Schistosoma mansoni in laboratory mice. Parasitology 70, 347–57.CrossRefGoogle ScholarPubMed
Sher, A., Smithers, S. R., Mackenzie, P. & Broomfield, K. (1977). Schistosoma mansoni: immunoglobulins involved in passive immunization of laboratory mice. Experimental Parasitology 41, 160–6.CrossRefGoogle ScholarPubMed
Smithers, S. R. (1967). The induction and nature of antibody responses to parasites. In Immunologic Aspects of Parasitic Infections. Pan American Health Organisation Scientific Publication No 150 pp. 43–49.Google Scholar
Vernes, A., Floo'h, F. & Biguet, J. (1972). L'hypersensibilité de type retardé au cours de la bilharziose expérimentale à Schistosoma mansoni. I. Etude in vitro chez la souris CBA. Annales de l' Institut Pasteur 123, 707–20.Google Scholar
Warren, K. S. (1961). The etiology of hepato-splenic schistosomiasis mansoni in mice. American Journal of Tropical Medicine and Hygiene 10, 870–6.CrossRefGoogle ScholarPubMed