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Modification of macrophage – T cell interaction during infection of mice with Mesocestoides corti (Cestoda)

Published online by Cambridge University Press:  06 April 2009

S. K. Kadian ,
J. B. Dixon ,
J. R. Green ,
S.D. Carter  and
P. Jenkins
S. K. Kadian
Affiliation:
Departments of Veterinary Pathology, University of Liverpool, Liverpool L69 3BX
J. B. Dixon
Affiliation:
Departments of Veterinary Pathology, University of Liverpool, Liverpool L69 3BX
J. R. Green
Affiliation:
Departments of Statistics and Computational Mathematics, University of Liverpool, Liverpool L69 3BX
S.D. Carter
Affiliation:
Departments of Veterinary Pathology, University of Liverpool, Liverpool L69 3BX
P. Jenkins
Affiliation:
Departments of Veterinary Pathology, University of Liverpool, Liverpool L69 3BX
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Extract

Peritoneal macrophages from Mesocestoides corti-infected mice showed a marked and progressive loss of ability to act as accessory cells for syngeneic Con A-stimulated mesenteric lymph node lymphocytes. The same effect on the macrophages could be induced by intraperitoneal injection of M. corti culture supernatant, despite a concurrent increase in numbers of peritoneal adhesive macrophages. The findings are used to compare and contrast the known immunomodulatory effects of M. corti and taeniid metacestodes, the latter differing chiefly in their potential for modifying T-cell as well as macrophage behaviour.

Keywords

Mesocestoides cortiimmunoregulationmacrophageaccessory cellT cellEchinococcus spp
Type
Research Article
Information
Parasitology , Volume 109 , Issue 5 , December 1994 , pp. 591 - 597
Copyright
Copyright © Cambridge University Press 1994

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References

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